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The impact of essential fatty acids on anxiety-related behaviors in mice

Research Project

Project/Area Number 16K16280
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Eating habits
Research InstitutionFukushima Medical University

Principal Investigator

Nobuyuki Sakayori  福島県立医科大学, 医学部, 博士研究員 (30747457)

Research Collaborator Kanno Chiaki  
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords多価不飽和脂肪酸 / 不安 / オープンフィールド試験 / ストレス / 高架式十字迷路試験 / 不安障害 / ドーパミン
Outline of Final Research Achievements

To reveal brain mechanism that consumption of an n-6 fatty acid-rich and n-3 fatty acid-poor diet induces anxious behaviors, we peformed behavioral and neurochemical analyses using mice. This study suggests that induced dopamine release in the ventral striatum is one of the causes that induce anxious behaviors in mice fed the n-6 fatty acid-rich and n-3 fatty acid-poor diet.

Academic Significance and Societal Importance of the Research Achievements

多くの先進国において、n-6脂肪酸を豊富に含む植物油などの摂取増加、およびn-3脂肪酸を豊富に含む魚などの摂取減少が進行しており、食中脂肪酸の高n-6 /低n-3状態は世界規模で深刻な問題となっている。このような食生活の変化が進行する現代社会において、本研究は不安障害の予防と新規治療法の開発に向けて基礎的知見を提供しうるものと期待される。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (24 results)

All 2019 2018 2017 2016

All Journal Article (8 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 7 results,  Open Access: 3 results) Presentation (16 results) (of which Int'l Joint Research: 5 results,  Invited: 3 results)

  • [Journal Article] Motor skills mediated through cerebellothalamic tracts projecting to the central lateral nucleus2019

    • Author(s)
      Nobuyuki Sakayori, Shigeki Kato, Masateru Sugawara, Susumu Setogawa, Hotaka Fukushima, Rie Ishikawa, Satoshi Kida, Kazuto Kobayashi
    • Journal Title

      Molecular Brain

      Volume: 12 Pages: 1-12

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Targeting the brain with a neuroprotective omega-3 fatty acid to enhance neurogenesis in hypoxic condition in culture2019

    • Author(s)
      Amanda Lo Van, Nobuyuki Sakayori, Mayssa Hachem, Mounir Belkouch, Madeleine Picq, Baptiste Fourmaux, Michel Lagarde, Noriko Osumi, Nathalie Bernoud-Hubac
    • Journal Title

      Molecular Neurobiology

      Volume: 56 Pages: 986-999

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 脳形成における必須脂肪酸の役割2018

    • Author(s)
      酒寄信幸、大隅典子
    • Journal Title

      脂質栄養学

      Volume: 27 Pages: 14-20

    • NAID

      130007405363

    • Related Report
      2017 Research-status Report
  • [Journal Article] 多価不飽和脂肪酸の大脳新皮質形成における役割2017

    • Author(s)
      酒寄信幸、大隅典子
    • Journal Title

      生化学

      Volume: 89 Pages: 269-272

    • NAID

      40021203383

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] 脳の発生・発達におけるDHAの役割2017

    • Author(s)
      酒寄信幸、大隅典子
    • Journal Title

      ビタミン

      Volume: 91 Pages: 547-554

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Mechanisms of DHA transport to the brain and potential therapy to neurodegenerative diseases.2016

    • Author(s)
      Lo Van A, Sakayori N, Hachem M, Belkouch M, Picq M, Lagarde M, Osumi N, Bernoud-Hubac N.
    • Journal Title

      Biochimie

      Volume: 130 Pages: 163-167

    • DOI

      10.1016/j.biochi.2016.07.011

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Maternal dietary imbalance between omega-6 and omega-3 polyunsaturated fatty acids impairs neocortical development via epoxy metabolites2016

    • Author(s)
      Sakayori N, Kikkawa T, Tokuda H, Kiryu E, Yoshizaki K, Kawashima H, Yamada T, Arai H, Kang JX, Katagiri H, Shibata H, Innis SM, Arita M, Osumi N.
    • Journal Title

      Stem Cells.

      Volume: 34 Issue: 2 Pages: 470

    • DOI

      10.1002/stem.2246

    • URL

      https://pure.teikyo.jp/en/publications/0a44dab9-77bc-49b5-a056-a4cdd3e66a1d

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Maternal Nutritional Imbalance between Linoleic Acid and Alpha-Linolenic Acid Increases Offspring’s Anxious Behavior with a Sex-Dependent Manner in Mice2016

    • Author(s)
      Sakayori, N., Tokuda, H., Yoshizaki, K., Kawashima, H., Innis, SM., Shibata, H. and Osumi, N
    • Journal Title

      The Tohoku Journal of Experimental Medicine

      Volume: 240 Issue: 1 Pages: 31-37

    • DOI

      10.1620/tjem.240.31

    • NAID

      130005406204

    • ISSN
      0040-8727, 1349-3329
    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] 現代の脂質食がもたらす意志力制御の先天的脆弱性と肥満2019

    • Author(s)
      酒寄信幸
    • Organizer
      新学術領域研究「意志動力学(ウィルダイナミクス)の創成と推進」第3回領域会議
    • Related Report
      2018 Annual Research Report
  • [Presentation] 脳と栄養の学際領域研究-脂質栄養から脳の謎に挑む-2019

    • Author(s)
      酒寄信幸
    • Organizer
      第8回東北脳科学ウィンタースクール
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 現代の脂質食がもたらす嗜好品過剰摂取の脳内メカニズム2018

    • Author(s)
      酒寄信幸、小林和人
    • Organizer
      第3回食欲・食嗜好の分子・神経基盤研究会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Dmrt genes regulate the development of Cajal-Retzius cells derived from specific origins in the cerebral cortex2018

    • Author(s)
      Takako Kikkawa, Nobuyuki Sakayori, Hayato Yuuki, Noriko Osumi
    • Organizer
      第41回日本神経科学大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Modern lipid diets drive intake of palatable foods through excess production of dopaminergic neurons2018

    • Author(s)
      Nobuyuki Sakayori
    • Organizer
      平成30年度第2回大脳基底核機能研究会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 現代の脂質食はドパミンニューロンの過剰産生を介して嗜好食品の摂取を促す2018

    • Author(s)
      酒寄信幸
    • Organizer
      次世代脳プロジェクト 冬のシンポジウム2018
    • Related Report
      2018 Annual Research Report
  • [Presentation] Roles of dietary lipids in brain development and function2017

    • Author(s)
      Nobuyuki Sakayori
    • Organizer
      新学術領域研究「意志動力学の創成と推進」若手の会WINGs The 1st Meeting
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] Dmrt genes control the development of Cajal-Retzius cells derived from specific origins in the cerebral cortex2017

    • Author(s)
      Takako Kikkawa, Nobuyuki Sakayori, Noriko Osumi
    • Organizer
      第40回日本神経科学大会
    • Related Report
      2017 Research-status Report
  • [Presentation] 妊娠中の偏った脂質摂取は仔の脳形成不全と不安障害を引き起こす2017

    • Author(s)
      酒寄信幸
    • Organizer
      第6回東北脳科学ウィンタースクール
    • Place of Presentation
      白石市(宮城県)
    • Related Report
      2016 Research-status Report
  • [Presentation] Study of the effects of docosahexaenoic acid (DHA) and a structured phospholipid containing DHA on an in vitro model of neurogenesis and stroke2016

    • Author(s)
      Amanda Lo Van, Nobuyuki Sakayori, Mayssa Hachem, Madeleine Picq, Michel Lagarde, Noriko Osumi, Nathalie Bernoud-Hubac
    • Organizer
      ICBL 2016
    • Place of Presentation
      Chamonix(フランス)
    • Year and Date
      2016-09-04
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] 妊娠中の偏った多価不飽和脂肪酸摂取は仔の大脳新皮質形成を妨げ不安を高める2016

    • Author(s)
      酒寄信幸、大隅典子
    • Organizer
      第70回日本栄養・食糧学会大会
    • Place of Presentation
      西宮市(兵庫県)
    • Related Report
      2016 Research-status Report
  • [Presentation] Unbalanced n-6/n-3 polyunsaturated fatty acid ratio disturbs neocortical development in mice2016

    • Author(s)
      Nobuyuki Sakayori, Noriko Osumi
    • Organizer
      International Conference on Omega-3 and Human Health
    • Place of Presentation
      Shanghai(中国)
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Study of the effects of docosahexaenoic acid (DHA) and a structured phospholipid containing DHA on an in vitro model of neurogenesis2016

    • Author(s)
      Amanda Lo Van, Nobuyuki Sakayori, Mayssa Hachem, Madeleine Picq, Michel Lagarde, Noriko Osumi, Nathalie Bernoud-Hubac
    • Organizer
      Journee IMBL 2016
    • Place of Presentation
      Lyon(フランス)
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] 妊娠中の偏った多価不飽和脂肪酸摂取は仔の大脳新皮質形成を妨げ不安を高める2016

    • Author(s)
      酒寄信幸、有田誠、大隅典子
    • Organizer
      日本脂質栄養学会第25回大会
    • Place of Presentation
      秋田市(秋田県)
    • Related Report
      2016 Research-status Report
  • [Presentation] Effects of unesterified docosahexaenoic acid (DHA) and a structured phospholipid containing DHA on neurogenesis and oxidation2016

    • Author(s)
      Amanda Lo Van, Nobuyuki Sakayori, Mayssa Hachem, Madeleine Picq, Michel Lagarde, Noriko Osumi, Nathalie Bernoud-Hubac
    • Organizer
      ELyT Workshop 2016
    • Place of Presentation
      蔵王町(宮城県)
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Effects of unesterified docosahexaenoic acid (DHA) and a structured phospholipid containing DHA on neurogenesis and oxidation2016

    • Author(s)
      Amanda Lo Van, Nobuyuki Sakayori, Mayssa Hachem, Madeleine Picq, Michel Lagarde, Noriko Osumi, Nathalie Bernoud-Hubac
    • Organizer
      Journee EDISS 2016
    • Place of Presentation
      Villeurbanne(フランス)
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research

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Published: 2016-04-21   Modified: 2021-01-27  

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