The impact of essential fatty acids on anxiety-related behaviors in mice
Project/Area Number |
16K16280
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Eating habits
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Research Institution | Fukushima Medical University |
Principal Investigator |
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Research Collaborator |
Kanno Chiaki
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Project Period (FY) |
2016-04-01 – 2019-03-31
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Project Status |
Completed (Fiscal Year 2018)
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Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
Keywords | 多価不飽和脂肪酸 / 不安 / オープンフィールド試験 / ストレス / 高架式十字迷路試験 / 不安障害 / ドーパミン |
Outline of Final Research Achievements |
To reveal brain mechanism that consumption of an n-6 fatty acid-rich and n-3 fatty acid-poor diet induces anxious behaviors, we peformed behavioral and neurochemical analyses using mice. This study suggests that induced dopamine release in the ventral striatum is one of the causes that induce anxious behaviors in mice fed the n-6 fatty acid-rich and n-3 fatty acid-poor diet.
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Academic Significance and Societal Importance of the Research Achievements |
多くの先進国において、n-6脂肪酸を豊富に含む植物油などの摂取増加、およびn-3脂肪酸を豊富に含む魚などの摂取減少が進行しており、食中脂肪酸の高n-6 /低n-3状態は世界規模で深刻な問題となっている。このような食生活の変化が進行する現代社会において、本研究は不安障害の予防と新規治療法の開発に向けて基礎的知見を提供しうるものと期待される。
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Report
(4 results)
Research Products
(24 results)
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[Journal Article] Maternal dietary imbalance between omega-6 and omega-3 polyunsaturated fatty acids impairs neocortical development via epoxy metabolites.2016
Author(s)
Sakayori N, Kikkawa T, Tokuda H, Kiryu E, Yoshizaki K, Kawashima H, Yamada T, Arai H, Kang JX, Katagiri H, Shibata H, Innis SM, Arita M, Osumi N.
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Journal Title
Stem Cells.
Volume: 34(2)
Issue: 2
Pages: 470-482
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Maternal Nutritional Imbalance between Linoleic Acid and Alpha-Linolenic Acid Increases Offspring’s Anxious Behavior with a Sex-Dependent Manner in Mice2016
Author(s)
Sakayori, N., Tokuda, H., Yoshizaki, K., Kawashima, H., Innis, SM., Shibata, H. and Osumi, N
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Journal Title
The Tohoku Journal of Experimental Medicine
Volume: 240
Issue: 1
Pages: 31-37
DOI
NAID
ISSN
0040-8727, 1349-3329
Related Report
Peer Reviewed / Int'l Joint Research
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