Analysis of the mechanism of anti-diabetic effect by polyacetylenes from the Apiaceae vegetables.
| Project/Area Number |
16K16284
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Eating habits
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| Research Institution | Iwate Medical University |
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Principal Investigator |
YOSHIDA Jun 岩手医科大学, 教養教育センター, 助教 (20611007)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | ポリアセチレン化合物 / falcarindiol / GSK-3β / セリ科植物 / 糖新生 / 機能性物質 / インスリン / 糖尿病 |
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| Outline of Final Research Achievements |
In this study, we investigated the mechanism of the anti-diabetic effect of falcarindiol isolated from Apiaceae family vegetables. Falcarindiol suppressed glucose production in rat hepatoma H4ⅡE cells. Falcarindiol also increased the level of inhibitory phosphorylation of GSK-3β in H4IIE cells. These results indicate that several Apiaceae family vegetables containing falcarindiol could be a useful food ingredient against type-2 diabetes.
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Report
(3 results)
Research Products
(9 results)
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[Journal Article] New eremophilane and dichlororesorcinol derivatives produced by endophytes isolated from Ficus ampelas.2017
Author(s)
Shiono Y., Muslihah I. N., Suzuki T., Ariefta R. N., Anwar C., Handojo Hadi Nurjanto H. H., Aboshi T., Murayama T., Tawaraya K., Koseki T., Yoshida J., Usukhbayar N., Uesugi S., Kimura K.
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Journal Title
The Journal of Antibiotics
Volume: 70
Issue: 12
Pages: 1133-1137
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] GSK-3β inhibitory activities of novel dichroloresorcinol derivatives from Cosmospora vilior isolated from a mangrove plant.2016
Author(s)
Shiono Y., Miyazaki N., Murayama T., Koseki T., Harizon, Katja D. G., Supratman U., Nakata J., Kakihara Y., Saeki M., Yoshida J., Uesugi S., Kimura K.
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Journal Title
Phytochemistry Letters
Volume: 18
Pages: 122-127
Related Report
Peer Reviewed
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