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Exploration of nutritional prophylaxis against mental disorders mediated by the alteration of gut microbiota

Research Project

Project/Area Number 16K16291
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Eating habits
Research InstitutionMeijo University

Principal Investigator

Nagasawa Mao  名城大学, 農学部, 助教 (80759564)

Co-Investigator(Renkei-kenkyūsha) HAYASHI Toshiya  名城大学, 農学部, 教授 (10304768)
Research Collaborator MARUI Moeko  
ADACHI Kaori  
Project Period (FY) 2016-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywords抗不安様効果 / 発酵乳 / プロバイオティクス / 海馬 / ストレス / 腸内環境 / Lactobacillus helveticus / 機能性食品
Outline of Final Research Achievements

The purpose of the present study was to establish the nutritional prophylaxis against mental disorders. Chronic supplementation of fermented milk with Lactobachillus helveticus, which is retained in our laboratory, induced the anxiolytic-like effect in rodent model. Chronic administration of viable Lactobachillus helveticus, not soluble and non-soluble fractions derived from fermented milk, exerted the anxiolytic-like effect. In addition, characteristic protein spots were detected in the hippocampus of mice with supplementation of the viable Lactobachillus helveticus. In conclusion, Lactobachillus Helveticus as probiotics has anxiolytic-like effect mediated by the novel protein expression in the hippocampus.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • Research Products

    (2 results)

All 2017

All Presentation (2 results)

  • [Presentation] 発酵乳を用いたストレス誘導性の脳機能障害の予防を目指して2017

    • Author(s)
      丸井萌子、長澤麻央、林利哉
    • Organizer
      日本畜産学会
    • Place of Presentation
      神戸大学
    • Year and Date
      2017-03-27
    • Related Report
      2016 Research-status Report
  • [Presentation] 乳製品を用いたストレス誘導性の脳機能障害の予防を目指して2017

    • Author(s)
      丸井萌子、長澤麻央、林利哉
    • Organizer
      日本畜産学会第122回大会
    • Related Report
      2017 Annual Research Report

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Published: 2016-04-21   Modified: 2019-03-29  

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