Molecular tension sensors visualize cell mechanical signal under mechanical stress
| Project/Area Number |
16K16387
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biomedical engineering/Biomaterial science and engineering
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| Research Institution | Okayama University |
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Principal Investigator |
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | メカノシグナル / 分子張力センサー / 機械刺激 / ずり応力 / 細胞接着斑 / メカノバイオロジー / シグナル伝達 / shear stress / 生物・生体工学 / 生物物理 |
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| Outline of Final Research Achievements |
We developed the shear stress applying system on the microscope and visualized focal adhesions motion and mechanical signal on real time. Our system revealed that focal adhesions and high mechanical signal are aligned to the parallel direction of flow direction. These results suggest integrin molecules use catch bond system.
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Report
(3 results)
Research Products
(9 results)
