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Development of autofluorescence-free Raman spectroscopy and its applications to biomedical imaging

Research Project

Project/Area Number 16K16389
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Biomedical engineering/Biomaterial science and engineering
Research InstitutionThe University of Tokushima

Principal Investigator

Minamikawa Takeo  徳島大学, 大学院社会産業理工学研究部(理工学域), 講師 (10637193)

Project Period (FY) 2016-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywordsラマン散乱分光法 / ラマン散乱 / 自家蛍光 / ラマン顕微鏡 / バイオイメージング / 計測工学 / 生物・生体工学 / 応用光学・量子光工学
Outline of Final Research Achievements

Raman spectroscopy is a promising technique to visualize molecular information of cells and tissues based on molecular vibrations. This is now widely applied to biomedical imaging and its molecular analysis. However, autofluorescence from specimens limits the sensitivity of Raman spectroscopic analysis due to the autofluorescence spectrum appears at the same wavelength of the Raman spectrum and works as a strong background. In this study, we developed a Raman spectroscopy system with an autofluroescence elimination system based on the excitation wavelength dependency of the Raman scattering and autofluroescence.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • Research Products

    (17 results)

All 2017 2016 Other

All Int'l Joint Research (1 results) Journal Article (5 results) (of which Peer Reviewed: 4 results) Presentation (9 results) (of which Int'l Joint Research: 3 results,  Invited: 5 results) Remarks (2 results)

  • [Int'l Joint Research] Universite de Bordeaux(フランス)

    • Related Report
      2016 Research-status Report
  • [Journal Article] Analytical imaging of colour pigments used in Japanese woodblock prints using Raman microspectroscopy2017

    • Author(s)
      Minamikawa Takeo、Nagai Daiki、Kaneko Takaaki、Taniguchi Ittetsu、Ando Mariko、Akama Ryo、Takenaka Kenji
    • Journal Title

      Journal of Raman spectroscopy

      Volume: 48 Issue: 12 Pages: 1887-1895

    • DOI

      10.1002/jrs.5263

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Photo-Induced Cell Damage Analysis for Single- and Multifocus Coherent Anti-Stokes Raman Scattering Microscopy2017

    • Author(s)
      Minamikawa Takeo、Murakami Yoshinori、Matsumura Naokazu、Niioka Hirohiko、Fukushima Shuichiro、Araki Tsutomu、Hashimoto Mamoru
    • Journal Title

      Journal of Spectroscopy

      Volume: 2017 Pages: 1-8

    • DOI

      10.1155/2017/5725340

    • NAID

      120006363259

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Raman spectroscopic detection of peripheral nerves towards nerve-sparing surgery2017

    • Author(s)
      Minamikawa Takeo、Harada Yoshinori、Takamatsu Tetsuro
    • Journal Title

      Proceedings of SPIE

      Volume: 10054 Pages: 100541E-100541E

    • DOI

      10.1117/12.2250807

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Simple and optimum background-free estimation method of PPIX fluorescence for 5-ALA-based fluorescence diagnosis of malignant lesions2017

    • Author(s)
      Minamikawa Takeo、Matsuo Hisataka、Kato Yoshiyuki、Harada Yoshinori、Otsuji Eigo、Yanagisawa Akio、Tanaka Hideo、Takamatsu Tetsuro
    • Journal Title

      Proceedings of SPIE

      Volume: 10047 Pages: 100470S-100470S

    • DOI

      10.1117/12.2250780

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 術中応用を目指したラマン散乱分光法=分子振動に基づく医療センシングの可能性=2017

    • Author(s)
      南川丈夫,原田義規,高松哲郎
    • Journal Title

      光アライアンス

      Volume: 28 Pages: 42-47

    • NAID

      40021196875

    • Related Report
      2017 Annual Research Report
  • [Presentation] 医療応用を目指したラマン散乱分光法2017

    • Author(s)
      南川丈夫
    • Organizer
      光材料・応用技術研究会 第4回研究会
    • Place of Presentation
      中央大学(東京都・文京区)
    • Year and Date
      2017-03-02
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] 浮世絵技法の復元的研究のための光計測・画像解析基盤技術の創出2017

    • Author(s)
      南川 丈夫, 永井 大規, 金子 貴昭, 谷口 一徹, 赤間 亮, 竹中 健司
    • Organizer
      文部科学省 共同利用・共同研究拠点 日本文化資源デジタル・アーカイブ研究拠点 2016年度成果発表会
    • Place of Presentation
      立命館大学(京都府・京都市)
    • Year and Date
      2017-02-17
    • Related Report
      2016 Research-status Report
  • [Presentation] Raman spectroscopic detection of peripheral nerves towards nerve-sparing surgery2017

    • Author(s)
      Takeo Minamikawa, Yoshinori Harada, and Tetsuro Takamatsu
    • Organizer
      SPIE Photonics West, Biomedical Optics (BiOS 2017)
    • Related Report
      2017 Annual Research Report 2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Simple and optimum background-free estimation method of PPIX fluorescence for 5-ALA-based fluorescence diagnosis of malignant lesions2017

    • Author(s)
      Takeo Minamikawa, Hisataka Matsuo, Yoshiyuki Kato, Yoshinori Harada, Eigo Otsuji, Akio Yanagisawa, Hideo Tanaka, and Tetsuro Takamatsu
    • Organizer
      SPIE Photonics West, Biomedical Optics (BiOS 2017)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 浮世絵技法の復元的研究のための光計測・画像解析基盤技術の創出2017

    • Author(s)
      南川 丈夫, 永井 大規, 金子 貴昭, 谷口 一徹, 安藤 真理子, 赤間 亮, 竹中 健司
    • Organizer
      文部科学省 共同利用・共同研究拠点 日本文化資源デジタル・アーカイブ研究拠点 2016年度成果発表会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Raman spectroscopic detection of peripheral nerves towards nerve-sparing surgery2017

    • Author(s)
      Takeo Minamikawa
    • Organizer
      CLEO-PR, OECC and PGC 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] ラマン分光センシング ~分子振動に基づく新たな無染色組織診断法~2017

    • Author(s)
      南川 丈夫
    • Organizer
      Translational Research Center (TRC) セミナー
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 医療応用を目指したラマン散乱分光法2017

    • Author(s)
      南川 丈夫
    • Organizer
      光材料・応用技術研究会 第4回研究会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 術中医療センシングを目指したラマン散乱分光法2016

    • Author(s)
      南川丈夫
    • Organizer
      BioOpt Japan 2016
    • Place of Presentation
      パシフィコ横浜(神奈川県・横浜市)
    • Year and Date
      2016-09-14
    • Related Report
      2016 Research-status Report
    • Invited
  • [Remarks] 徳島大学 大学院社会産業理工学研究部 理工学域 機械科学系 生産工学分野 先端フォトニクス研究室

    • URL

      https://femto.me.tokushima-u.ac.jp/member/minamikawa/

    • Related Report
      2017 Annual Research Report
  • [Remarks] 徳島大学 大学院社会産業理工学研究部 南川研究室 webサイト

    • URL

      http://femto.me.tokushima-u.ac.jp/member/minamikawa/j/

    • Related Report
      2016 Research-status Report

URL: 

Published: 2016-04-21   Modified: 2019-03-29  

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