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Real-time risk measurement of blood coagulation in extracorporeal circulation

Research Project

Project/Area Number 16K16394
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Biomedical engineering/Biomaterial science and engineering
Research InstitutionKisarazu National College of Technology

Principal Investigator

SAPKOTA ACHYUT  木更津工業高等専門学校, 情報工学科, 准教授 (70724706)

Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords血液凝固 / 生体電気計測 / 体外循環 / 人工臓器 / メタボローム解析 / 生物ー生体工学
Outline of Final Research Achievements

Blood coagulation is a major problem in extracorporeal circulations. In order to address this problem, there is a need to evaluate coagulation risk and administer the anticoagulation therapy. However, existing technologies are not capable of evaluating the coagulation risk in real time. Blood coagulation risks can be summarized in terms of virchow’s triad ( abnormal blood constituent, abnormal flow and abnormal cell line). In this work, molecular blood coagulation biomarkers ( abnormal blood consistent) and biophysical properties of blood cells and blood flow(abnormal flow parameters) were analyzed, and risk was evaluated in terms of electrical parameters.

Academic Significance and Societal Importance of the Research Achievements

本研究の特色と独創的な点は、本研究が生化学情報処理と電気信号処理のノウハウを踏まえたシステムバイオロジーにおける意思決定支援システムの新しいアプローチである点にある。本研究の成果は、医療現場における血液凝固の管理を可能とする画期的なシステムにつながり、血液の状況をリアルタイムで計測し、血液体外循環装置を利用する患者の自宅や病室、手術室など様々な医療現場で抗凝固処置を最適に行うことができるようになる。従って、将来的には患者の命を守るだけではなく、患者の生活の質(QOL)の向上および医療費削減にも結びつくことが予想される。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (13 results)

All 2019 2018 2017 2016 Other

All Journal Article (3 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 3 results) Presentation (9 results) (of which Int'l Joint Research: 8 results,  Invited: 1 results) Remarks (1 results)

  • [Journal Article] Linear relationship between cytoplasm resistance and hemoglobin in red blood cell hemolysis by electrical impedance spectroscopy & eight-parameter equivalent circuit2018

    • Author(s)
      Tran A. Kiet、Sapkota Achyut、Wen Jianming、Li Jianping、Takei Masahiro
    • Journal Title

      Biosensors and Bioelectronics

      Volume: 119 Pages: 103-109

    • DOI

      10.1016/j.bios.2018.08.012

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Quantitative evaluation of electrical parameters influenced by blood flow rate with multiple-frequency measurement based on modified Hanai mixture formula2018

    • Author(s)
      Jianping Li, Daisuke Kikuchi, Achyut Sapkota and MasahiroTakei
    • Journal Title

      Sensors and Actuators B: Chemical

      Volume: 268 Pages: 7-14

    • DOI

      10.1016/j.snb.2018.04.077

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Red blood cells aggregability measurement of coagulating blood in extracorporeal circulation system with multiple-frequency electrical impedance spectroscopy2018

    • Author(s)
      Jianping Li, Achyut Sapkota, Daisuke Kikuchi, Daisuke Sakota, Osamu Maruyama, and Masahiro Takei
    • Journal Title

      Biosensors and Bioelectronics

      Volume: 112 Pages: 79-85

    • DOI

      10.1016/j.bios.2018.04.020

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] Metabolome analysis for new possible hemostasis biomarkers2019

    • Author(s)
      Achyut Sapkota
    • Organizer
      63rd Annual Meeting of the Society of Thrombosis and Haemostasis Research
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Use of Bioinformatic tools in diagnostic stewardship2018

    • Author(s)
      Achyut Sapkota
    • Organizer
      Africa International Biotechnology and Biomedical Conference
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Visualization of interrelated biological words using iterative data mining2018

    • Author(s)
      Achyut Sapkota, Kazunori Hamada
    • Organizer
      9th international meeting on Visualizing Biological Data
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Electrical circuit modeling and experimental evaluation of the blood undergoing thromobosis2017

    • Author(s)
      Achyut Sapkota
    • Organizer
      61st Biophysical society annual meeting
    • Place of Presentation
      New Orleans, USA
    • Year and Date
      2017-02-11
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Quantitative analysis of the relaxation frequency of blood during the thrombus formation process2017

    • Author(s)
      Jianping Li, Nguyen Huu Dung, Daisuke Kikuchi, Madoka Koishi, Osamu Maruyama, Achyut Sapkota and Masahiro Takei
    • Organizer
      第39回日本血栓止血学会集会
    • Related Report
      2017 Research-status Report
  • [Presentation] Application of electrical capacitance tomography on thrombus detection in blood extracorporeal circulation systems2017

    • Author(s)
      Jianping Li, Daisuke Kikuchi, Madoka Koishi, Achyut Sapkota and Masahiro Takei
    • Organizer
      18th International Conference on Biomedical Applications of Electrical Impedance Tomography
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Point-of-care coagulation test using electrical signal analysis in blood2016

    • Author(s)
      Achyut Sapkota
    • Organizer
      International conference on Thrombosis and Embolism
    • Place of Presentation
      Stockholm, Sweden
    • Year and Date
      2016-11-17
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Electrical impedance spectroscopy tomography for blood flow visualization2016

    • Author(s)
      Achyut Sapkota
    • Organizer
      8th World Congress on Industrial Process Tomography
    • Place of Presentation
      Igaussu Falls, Brazil
    • Year and Date
      2016-09-26
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Analysis of blood coagulation time in terms of coagulation pathway and blood electrical properties2016

    • Author(s)
      Achyut Sapkota
    • Organizer
      The 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
    • Place of Presentation
      Orlando, USA
    • Year and Date
      2016-08-17
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Remarks] Research Map- Achyut Sapkota

    • URL

      https://researchmap.jp/sapkota

    • Related Report
      2018 Annual Research Report

URL: 

Published: 2016-04-21   Modified: 2020-03-30  

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