| Project/Area Number |
16K16397
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biomedical engineering/Biomaterial science and engineering
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| Research Institution | University of Tsukuba |
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Principal Investigator |
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | injectable hydrogel / nitric oxide / myocardial infarction / reactive oxygen species / redox nanoparticle / redox injectable gel / cardiovascular disease / angiogenesis / ナノバイオ / 薬学 / 物性・分子工学 / ナノ材料 |
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| Outline of Final Research Achievements |
Research Summary: In this study, we developed a controllable nitric oxide (NO)-releasing injectable hydrogel (NO-RIG) formed by the electrostatic irreversibly crosslinking between the polyion complex flower-type micelles composing of functional polymers to scavenge overproduced reactive oxide species (ROS) and regulate the local NO expression level simultaneously. Treatment with NO-RIG remarkably decreased the infarction size and improved the heart function after myocardial infarction when compared to control injectable hydrogels, such as a simple NO-releasing or ROS-scavenging injectable gels. We found that NO-RIG treatment significantly enhanced the angiogenesis in mice through the regulation of the NO sustained release and redox equilibrium. NO- RIG presents high potential in preventing and treating cardiovascular diseases.
- This work was published in Biomaterials (2018) and presented in Polymer meeting, Gelsymposium, American chemistry Society Meeting
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