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Development of bioactive PEEK that spontaneously bond to living bone

Research Project

Project/Area Number 16K16401
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Biomedical engineering/Biomaterial science and engineering
Research InstitutionKyoto University

Principal Investigator

Yabutsuka Takeshi  京都大学, エネルギー科学研究科, 助教 (20574015)

Project Period (FY) 2016-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
KeywordsPEEK / 繊維強化PEEK / アパタイト核 / アパタイト形成能 / 硫酸処理 / グロー放電処理 / 表面構造 / 生体活性 / ポリエーテルエーテルケトン(PEEK) / 細孔形成 / 擬似体液 / インターロッキング効果 / 生体材料 / セラミックス / 無機工業化学 / 複合材料・物性 / 生物・生体工学
Outline of Final Research Achievements

By sulfuric acid treatment, mesh-like pores were formed on the surfaces of PEEK and fiber-reinforced PEEK. Then, bioactive PEEK and bioactive fiber reinforced PEEK were obtained by subsequent glow-discharge treatment and apatite nuclei treatment. It was found that the untreated substrate and acid-treated one showed hydrophobicity, whereas the glow-discharge-treated substrate and subsequently apatite nuclei-treated one showed hydrophilicity. After sulfuric acid treatment, formation of sulfo groups was shown. After the subsequent glow-discharge treatment, increase of sulfo groups and formation of carboxyl groups were shown. When the bioactive substrates were immersed in SBF, it was found that the entire surfaces were covered with apatite layer within 1 day and high apatite-forming ability was achieved.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • Research Products

    (18 results)

All 2018 2017 2016

All Journal Article (6 results) (of which Peer Reviewed: 5 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (11 results) (of which Int'l Joint Research: 6 results) Book (1 results)

  • [Journal Article] Effective Procedure of Bioactivity Treatment to Bearing Grade PEEK by Incorporation of Apatite Nuclei2018

    • Author(s)
      Tomoko Hiruta, Takeshi Yabutsuka, Keito Fukushima, Shigeomi Takai, Takeshi Yao
    • Journal Title

      Trans. Mat. Res. Soc. Japan

      Volume: 印刷中

    • NAID

      130007382918

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of Pores Formation Process and Oxygen Plasma Treatment to Hydroxyapatite Formation on Bioactive PEEK Prepared by Incorporation of Precursor of Apatite2017

    • Author(s)
      Takeshi Yabutsuka, Keito Fukushima, Tomoko Hiruta, Shigeomi Takai, Takeshi Yao
    • Journal Title

      Mater. Sci. Eng. C

      Volume: 81 Pages: 349-358

    • DOI

      10.1016/j.msec.2017.07.017

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fabrication of Bioactive Fiber-reinforced PEEK and MXD6 by Incorporation of Precursor of Apatite2017

    • Author(s)
      Takeshi Yabutsuka, Keito Fukushima, Tomoko Hiruta, Shigeomi Takai, Takeshi Yao
    • Journal Title

      J. Biomed. Mater. Res. B: Appl. Biomater.

      Volume: 印刷中 Issue: 6 Pages: 2254-2265

    • DOI

      10.1002/jbm.b.34025

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Apatite Formation Ability of Bioactive Bearing Grade Polyetheretherketone Fabricated by Incorporation of Apatite Nuclei2017

    • Author(s)
      Tomoko Hiruta, Takeshi Yabutsuka, Shin Watanabe, Keito Fukushima, Shigeomi Takai, Takeshi Yao
    • Journal Title

      Bioceramics

      Volume: 29 Pages: 69-74

    • DOI

      10.4028/www.scientific.net/kem.758.69

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] た機能性バイオ材料アパタイト核を用いの創成―人工骨からDDSまで2017

    • Author(s)
      薮塚武史
    • Journal Title

      セラミックス

      Volume: 52 Pages: 482-483

    • Related Report
      2017 Annual Research Report
    • Open Access
  • [Journal Article] Fabrication of Bioactive Fiber Reinforced Polyetheretherketone by the Function of Apatite Nuclei2017

    • Author(s)
      Takeshi Yabutsuka, Keito Fukushima, Yasutaka Kidokoro, Takahiko Matsunaga, Shigeomi Takai, Takeshi Yao
    • Journal Title

      Bioceramics

      Volume: 28 Pages: 246-251

    • DOI

      10.4028/www.scientific.net/kem.720.246

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] 生体活性PEEKのアパタイト形成能およびアパタイト核の無機イオン放出・消費挙動2018

    • Author(s)
      薮塚武史、昼田智子、福島啓斗、高井茂臣、八尾 健
    • Organizer
      日本セラミックス協会2018年年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Bioactivity Treatment to Bearing Grade PEEK by Incorporation of Apatite Nuclei2017

    • Author(s)
      Tomoko Hiruta, Takeshi Yabutsuka, Shigeomi Takai, Takeshi Yao
    • Organizer
      The 15th International Conference on Advanced Materials (IUMRS-ICAM 2017)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Fabrication of Bioactive Bearing Grade PEEK by Incorporation of Apatite Nuclei2017

    • Author(s)
      Tomoko Hiruta, Takeshi Yabutsuka, Shin Watanabe, Keito Fukushima, Shigeomi Takai, Takeshi Yao
    • Organizer
      29th Symposium & Annual Meeting of the International Society for Ceramics in Medicine
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Effective treatment for imparting bioactivity to carbon fibers/graphite/PTFE-reinforced PEEK by incorporation of apatite nuclei2017

    • Author(s)
      Tomoko Hiruta, Takeshi Yabutsuka, Keito Fukushima, Shin Watanabe, Shigeomi Takai, Takeshi Yao
    • Organizer
      17th Asian BioCeramics Symposium
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] アパタイト核を用いた摺動グレードPEEKへの生体活性付与2017

    • Author(s)
      昼田智子、薮塚武史、福島啓斗、高井茂臣、八尾 健
    • Organizer
      第39回日本バイオマテリアル学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Preparation of Bioacvtive Polymeric Implant Materials by the Function of Apatite Nuclei2016

    • Author(s)
      Takeshi Yabutsuka, Keito Fukushima, Hiroshi Mizuno, Shigeomi Takai, Takeshi Yao
    • Organizer
      10th World Biomaterials Congress
    • Place of Presentation
      モントリオール(カナダ)
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Bioactivity Treatment to Polyetheretherketone by the Function of Apatite Nuclei2016

    • Author(s)
      Takeshi Yabutsuka, Keito Fukushima, Tomoko Hiruta, Yasutaka Kidokoro, Takahiko Matsunaga, Shigeomi Takai, Takeshi Yao
    • Organizer
      The 9th International Symposium on Inorganic Phosphate Materials
    • Place of Presentation
      首都大学東京(東京都八王子市)
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Fabrication of Bioactive Fiber Reinforced PEEK by the Function of Apatite Nuclei2016

    • Author(s)
      Takeshi Yabutsuka, Keito Fukushima, Yasutaka Kidokoro, Takahiko Matsunaga, Shigeomi Takai, Takeshi Yao
    • Organizer
      The 28th Symposium & Annual Meeting of the International Society for Ceramics in Medicine
    • Place of Presentation
      シャーロット(アメリカ合衆国)
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] アパタイト核処理による生体活性繊維強化PEEKの開発2016

    • Author(s)
      薮塚武史、福島啓斗、昼田智子、城所泰孝、松永孝彦、高井茂臣、八尾 健
    • Organizer
      日本バイオマテリアル学会シンポジウム2016
    • Place of Presentation
      福岡国際会議場(福岡県福岡市)
    • Related Report
      2016 Research-status Report
  • [Presentation] アパタイト核処理による繊維強化PEEKへのアパタイト形成能の付与2016

    • Author(s)
      薮塚武史、福島啓斗、昼田智子、城所泰孝、松永孝彦、高井茂臣、八尾 健
    • Organizer
      第20回生体関連セラミックス討論会
    • Place of Presentation
      大阪大学銀杏会館(大阪府吹田市)
    • Related Report
      2016 Research-status Report
  • [Presentation] 自発的に骨を結合する生体活性PEEK材料の創成2016

    • Author(s)
      薮塚武史
    • Organizer
      ニューセラミックス懇話会第225回特別研究会
    • Place of Presentation
      たかつガーデン(大阪府大阪市)
    • Related Report
      2016 Research-status Report
  • [Book] Porous Ceramics (edited by Uday Basheer)2018

    • Author(s)
      Takeshi Yabutsuka
    • Total Pages
      21
    • Publisher
      InTech
    • Related Report
      2017 Annual Research Report

URL: 

Published: 2016-04-21   Modified: 2019-03-29  

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