Development of bioactive PEEK that spontaneously bond to living bone
| Project/Area Number |
16K16401
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biomedical engineering/Biomaterial science and engineering
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | PEEK / 繊維強化PEEK / アパタイト核 / アパタイト形成能 / 硫酸処理 / グロー放電処理 / 表面構造 / 生体活性 / ポリエーテルエーテルケトン（PEEK） / 細孔形成 / 擬似体液 / インターロッキング効果 / 生体材料 / セラミックス / 無機工業化学 / 複合材料・物性 / 生物・生体工学 |
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| Outline of Final Research Achievements |
By sulfuric acid treatment, mesh-like pores were formed on the surfaces of PEEK and fiber-reinforced PEEK. Then, bioactive PEEK and bioactive fiber reinforced PEEK were obtained by subsequent glow-discharge treatment and apatite nuclei treatment. It was found that the untreated substrate and acid-treated one showed hydrophobicity, whereas the glow-discharge-treated substrate and subsequently apatite nuclei-treated one showed hydrophilicity. After sulfuric acid treatment, formation of sulfo groups was shown. After the subsequent glow-discharge treatment, increase of sulfo groups and formation of carboxyl groups were shown. When the bioactive substrates were immersed in SBF, it was found that the entire surfaces were covered with apatite layer within 1 day and high apatite-forming ability was achieved.
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Report
(3 results)
Research Products
(18 results)
