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Integrate the statistical characteristics of biomedical images and the radiologist's knowledge for the detection of brain diseases

Research Project

Project/Area Number 16K16407
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Medical systems
Research InstitutionKyoto University

Principal Investigator

Yamamoto Utako  京都大学, 情報学研究科, 特定助教 (70707405)

Research Collaborator Yamada Kei  京都府立医科大学
Hiroyasu Tomoyuki  同志社大学
Ohzeki Masayuki  東北大学
Matsuda Tetsuya  京都大学
Nakao Megumi  京都大学
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2018: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Keywords領域ラベリング / MRI / 拡散テンソル画像法 / ボルツマン機械学習 / ベイズ推定 / スパースモデリング / ラベリング / 領域分割 / ニューラルネットワーク / 信念伝播法 / 拡散テンソル画像 / 脳MRI / 画像ラベリング / スパース推定
Outline of Final Research Achievements

We integrate the statistical characteristics of human brain MRI images and the radiologist’s knowledge about the clinical images to support the interpretation of radiogram. The MR diffusion tensor images which had multiple kinds of contrast were employed as feature vectors. Label maps which were classified to anatomical regions by a radiologist were utilized as supervised label. We developed the labeling technique for brain MRI images based on the Bayesian inference and Boltzmann machine learning. And we developed the reconstruction method of biomedical spectroscopic data obtained by MRI using sparse modeling technique.
We made research presentations and discussed about these results in some research conferences by The Japanese Society for Magnetic Resonance in Medicine, The International Society for Magnetic Resonance in Medicine, etc.

Academic Significance and Societal Importance of the Research Achievements

本研究では、放射線科医による読影を疾患の自動検出によりサポートする際に問題となる、画像の領域ラベリングについての研究を行った。MRI画像の輝度値についての情報と医師によりラベリングされた標準脳のラベルを学習し、新しく得た個人のMRI画像のラベルを推定する手法を開発した。脳や臓器など特定の領域の形状に特化した推定手法ではなく、本研究で開発したラベリング手法は、生体画像の様々な領域に適用することができる。また、スパースモデリングを用いて生体のスペクトルデータから生体内物質の空間分布を再構成する提案手法は、MRIの計測時間を大幅に減少させることが期待できる。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (18 results)

All 2018 2017 2016 Other

All Journal Article (5 results) (of which Peer Reviewed: 2 results,  Open Access: 2 results,  Acknowledgement Compliant: 1 results) Presentation (11 results) (of which Int'l Joint Research: 4 results,  Invited: 3 results) Remarks (2 results)

  • [Journal Article] 日本生体医工学会 平成二十九年度各賞受賞者紹介2018

    • Author(s)
      山本 詩子
    • Journal Title

      Transactions of Japanese Society for Medical and Biological Engineering

      Volume: 56 Issue: 3 Pages: 81-86

    • DOI

      10.11239/jsmbe.56.81

    • NAID

      130007536134

    • ISSN
      1347-443X, 1881-4379
    • Year and Date
      2018-06-10
    • Related Report
      2018 Annual Research Report
    • Open Access
  • [Journal Article] Improving Time Resolution in the Imaging of Metabolic Dynamics using Compressed Sensing from 2D Heteronuclear Multiple Quantum Coherence2018

    • Author(s)
      Utako Yamamoto and Hirohiko Imai and Kei Sano and Masayuki Ohzeki and Tetsuya Matsuda and Toshiyuki Tanaka
    • Journal Title

      Proceedings of The International Society for Magnetic Resonance in Medicine 26

      Volume: 26 Pages: 1289-1289

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Evaluating working memory capacity with functional near-infrared spectroscopy measurement of brain activity2018

    • Author(s)
      Utako Yamamoto, Nozomi Mashima, Tomoyuki Hiroyasu
    • Journal Title

      Journal of Cognitive Enhancement

      Volume: 印刷中 Issue: 3 Pages: 217-224

    • DOI

      10.1007/s41465-017-0063-y

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] 弾性体の部分観測によるニューラルネットワークを用いた変形推定2017

    • Author(s)
      山本 詩子、中尾 恵、大関 真之、松田 哲也
    • Journal Title

      電子情報通信学会技術研究報告

      Volume: 116

    • Related Report
      2016 Research-status Report
    • Open Access / Acknowledgement Compliant
  • [Journal Article] Anatomical labeling with belief propagation in Bayes estimation for human brain / 信念伝播法を用いたベイズ推定による脳画像の自動ラベリング手法の検討2016

    • Author(s)
      Utako Yamamoto, Masayuki Ohzeki, Tomoyuki Hiroyasu, Megumi Nakao and Tetsuya Matsuda
    • Journal Title

      日本磁気共鳴医学会雑誌 第44回日本磁気共鳴医学会大会 講演抄録集

      Volume: 36S Pages: 321-321

    • Related Report
      2016 Research-status Report
  • [Presentation] Application of Q-Adam to deep neural network for deformation estimation of elastic object2018

    • Author(s)
      Utako Yamamoto and Masayuki Ohzeki and Megumi Nakao and Tetsuya Matsuda
    • Organizer
      7th Adiabatic Quantum Computing Conference 2018 (AQC-18)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Improvement of Temporal Resolution for Spatio-temporal Reconstruction using Compressed Sensing in 2D 1H-13C HMQC MRSI2018

    • Author(s)
      Utako Yamamoto and Hirohiko Imai and Kei Sano and Masayuki Ohzeki and Tetsuya Matsuda and Toshiyuki Tanaka
    • Organizer
      第46回日本磁気共鳴医学会大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Fiber tractography connected me to medical imaging field2018

    • Author(s)
      Utako Yamamoto
    • Organizer
      脳拡散テンソルトラクトグラフィー講演会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Application of concept of quantum annealing to deep neural network for deformation estimation of elastic object2018

    • Author(s)
      Utako Yamamoto, Masayuki Ohzeki, Megumi Nakao, Tetsuya Matsuda
    • Organizer
      Congress Quantum Machine Learning and Biomimetic Quantum Technologies
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Shape estimation of elastic object with neural network2017

    • Author(s)
      Utako Yamamoto, Megumi Nakao, Masayuki Ohzeki and Tetsuya Matsuda
    • Organizer
      2017 Workshop on Statistical Physics of Disordered Systems and Its Applications (SPDSA2017)
    • Place of Presentation
      Sendai city、Akiu Resort Hotel Sakan
    • Year and Date
      2017-02-08
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] ヒトの臓器を模した弾性体の変形シミュレーションへの機械学習の応用2017

    • Author(s)
      山本 詩子、中尾 恵、大関 真之、松田 哲也
    • Organizer
      AIMR2017 構造イメージングと情報処理研究会
    • Place of Presentation
      仙台市、東北大学
    • Year and Date
      2017-02-06
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] 弾性体の部分観測によるニューラルネットワークを用いた変形推定2017

    • Author(s)
      山本 詩子、中尾 恵、大関 真之、松田 哲也
    • Organizer
      情報処理学会 コンピュータビジョンとイメージメディア研究会(CVIM2017)
    • Place of Presentation
      京都市、京都大学
    • Year and Date
      2017-01-19
    • Related Report
      2016 Research-status Report
  • [Presentation] カーネル法を用いた弾性体の部分観測情報に基づく変形推定 / Estimation of elastic deformation by partial observation with kernel method2017

    • Author(s)
      山本 詩子、中尾 恵、大関 真之、松田 哲也
    • Organizer
      第56回日本生体医工学会大会
    • Related Report
      2017 Research-status Report
  • [Presentation] Time-series reconstruction using compressed sensing with ADMM in 2D magnetic resonance spectroscopic imaging2017

    • Author(s)
      Utako YAMAMOTO, Hirohiko IMAI, Kei SANO, Masayuki OHZEKI, Tetsuya MATSUDA, Toshiyuki TANAKA
    • Organizer
      International Meeting on “High-Dimensional Data-Driven Science”
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Time-series reconstruction using compressed sensing in 2D 1H-13C heteronuclear multiple quantum coherence MRSI / 2次元1H-13C異核種多量子コヒーレンスMRSIにおける圧縮センシングを用いた時系列再構成2017

    • Author(s)
      Utako YAMAMOTO, Hirohiko IMAI, Kei SANO, Masayuki OHZEKI, Tetsuya MATSUDA, Toshiyuki TANAKA
    • Organizer
      第45回日本磁気共鳴医学会大会
    • Related Report
      2017 Research-status Report
  • [Presentation] Anatomical labeling with belief propagation in Bayes estimation for human brain / 信念伝播法を用いたベイズ推定による脳画像の自動ラベリング手法の検討2016

    • Author(s)
      Utako Yamamoto, Masayuki Ohzeki, Tomoyuki Hiroyasu, Megumi Nakao and Tetsuya Matsuda
    • Organizer
      第44回日本磁気共鳴医学会大会
    • Place of Presentation
      さいたま市、大宮ソニックシティ
    • Year and Date
      2016-09-09
    • Related Report
      2016 Research-status Report
  • [Remarks] 京都大学 教育研究活動データベース

    • URL

      https://kyouindb.iimc.kyoto-u.ac.jp/j/uO9eG

    • Related Report
      2018 Annual Research Report
  • [Remarks] Publications

    • URL

      http://www.bme.sys.i.kyoto-u.ac.jp/~meg/publication.html

    • Related Report
      2016 Research-status Report

URL: 

Published: 2016-04-21   Modified: 2020-03-30  

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