| Project/Area Number |
16K16409
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Medical systems
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 非アルコール性脂肪肝炎 / DNP-MRI / レドックス / ミトコンドリア / 画像診断システム / 酸化ストレス / in vivo DNP-MRI / in vivo イメージング / 分子イメージング |
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| Outline of Final Research Achievements |
The prevalence of nonalcoholic fatty liver disease (NAFLD) is rising as not only an adult disease but also pediatric disease. In order to evaluate the progress of the disease non-invasively to non-alcoholic steatohepatitis (NASH), a new Development of diagnostic methods is an important research objective. Liver biopsy, which is a standard diagnostic technique of NASH, has several drawbacks, including the risk of complications associated with invasive procedures. Here we demonstrate that biomedical nuclear polarized magnetic resonance imaging using carbamoyl-PROXYL as a molecular imaging probe can detect dramatical change of mitochondrial redox metabolism in vivo in the early stages before histopathological change , and clarified that early pathology of NASH can be detected.
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