Development of noninvasive diagnostic imagingfor NASH using redox molecular imaging

• Project/Area Number: 16K16409
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Medical systems
• Research Institution: Kyushu University
• Principal Investigator: Nakata Ryosuke 九州大学, 大学病院, 医員 (70614759)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 非アルコール性脂肪肝炎 / DNP-MRI / レドックス / ミトコンドリア / 画像診断システム / 酸化ストレス / in vivo DNP-MRI / in vivo イメージング / 分子イメージング

Outline of Final Research Achievements

The prevalence of nonalcoholic fatty liver disease (NAFLD) is rising as not only an adult disease but also pediatric disease. In order to evaluate the progress of the disease non-invasively to non-alcoholic steatohepatitis (NASH), a new Development of diagnostic methods is an important research objective. Liver biopsy, which is a standard diagnostic technique of NASH, has several drawbacks, including the risk of complications associated with invasive procedures. Here we demonstrate that biomedical nuclear polarized magnetic resonance imaging using carbamoyl-PROXYL as a molecular imaging probe can detect dramatical change of mitochondrial redox metabolism in vivo in the early stages before histopathological change , and clarified that early pathology of NASH can be detected.

Research Products

• [Journal Article] In vivo redox metabolic imaging of mitochondria assesses disease progression in non-alcoholic steatohepatitis (2017)
  • Author(s): Nakata R, Hyodo F, Murata M, Eto H, Nakaji T, Kawano T, Narahara S, Yasukawa K, Akahoshi T, Tomikawa M, Hashizume M
  • Journal Title: Sci Rep. Volume: 7 Issue: 1 Pages: 17170-17170
  • DOI: 10.1038/s41598-017-17447-2
  • Peer Reviewed / Open Access
• [Presentation] The assessment of mitochondrial redox metabolism by In vivo dynamic nuclear polarization-magnetic resonance imaging for non-alcoholic steatohepatitis (2017)
  • Author(s): Ryosuke Nakata
  • Organizer: DDW2017
  • Int'l Joint Research
• [Patent(Industrial Property Rights)] フリーラジカルの消費速度情報の取得方法およびNASHの判定方法 (2016)
  • Inventor(s): 村田正治、兵藤文紀、橋爪 誠、中田亮輔、赤星朋比古
  • Industrial Property Rights Holder: 村田正治、兵藤文紀、橋爪 誠、中田亮輔、赤星朋比古
  • Industrial Property Rights Type: 特許
  • Filing Date: 2016-06-13