Elucidation of the molecular mechanism involved in the development of muscle contracture and verification of the biological effect of prevention strategy in physical therapy
| Project/Area Number |
16K16427
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Rehabilitation science/Welfare engineering
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| Research Institution | Nagasaki University |
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Principal Investigator |
HONDA Yuichiro 長崎大学, 病院(医学系), 技術職員 (40736344)
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| Research Collaborator |
OKITA Minoru
SAKAMOTO Jyunya
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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| Keywords | 筋性拘縮 / 線維化 / 不動 / マクロファージ / 筋核 / アポトーシス / 筋収縮運動 / リハビリテーション / 電気刺激療法 / MCP-1 / 筋線維萎縮 |
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| Outline of Final Research Achievements |
Macrophage accumulation was regarded as an important lesion in the developmental mechanism of muscle contracture, the detailed molecular mechanism of macrophage accumulation had been unknown. In present study, we investigated the molecular mechanism of macrophage accumulation in immobilized rat soleus muscle. As results, our research revealed that myonuclear apoptosis played an important role as the trigger of macrophage accumulation in immobilized rat soleus muscle. Additionally, our study confirmed the biological effect of tetanus exercise by belt electrode-skeletal muscle electrical stimulation (B-SES) to muscle contracture. Resulting in, the tetanus exercise by B-SES suppressed the occurrence of muscle fibrosis, this intervention was effective prevention strategy to the development of muscle contracture.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究の特色は，筋性拘縮の発生に直接的に関わる標的分子を探索した点にあり，メカニズムを踏まえた治療戦略の開発につながる基礎資料として重要と考えている．具体的には，本研究の成果によって筋線維萎縮が先行して生じることが筋性拘縮の発生の分子シグナリングに寄与していることが明らかになり，筋線維萎縮の予防が筋性拘縮の発生予防対策につながる可能性が見出された．加えて，臨床において筋線維萎縮の予防対策として活用されている電気刺激誘発性筋収縮運動は，筋性拘縮の発生予防対策としても有効であることが示唆される．つまり，本研究成果は理学療法のエビデンス構築に大きく貢献すると思われ，その意義は大きいと考えている．
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Report
(4 results)
Research Products
(50 results)
