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Evaluation of local arteriosclerosis using shear wave elastography

Research Project

Project/Area Number 16K16432
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Rehabilitation science/Welfare engineering
Research InstitutionSapporo Medical University

Principal Investigator

Iwamoto Erika  札幌医科大学, 保健医療学部, 講師 (40632782)

Project Period (FY) 2016-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2018: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Keywordsshear-wave elastography / arterial stiffness / arteriosclerosis / menstrual cycle / aerobic exercise / 剪断波エラストグラフィ / 動脈硬化 / 血管 / スティフネス / 機能的 / 器質的 / 血管コンプライアンス / βスティフネス / 脈波伝搬速度 / 血管スティフネス / 月経周期 / 動脈スティフネス / 総頸動脈 / 内頸動脈 / 外頸動脈 / 女性 / エラストグラフィ / リハビリテーション / 循環器
Outline of Final Research Achievements

The purpose of this study was to verify the evaluation of arteriosclerosis using the shear wave elastography (ultrasound tissue elastic imaging) which is a new imaging that images local arterial stiffness. Specifically, we aimed to clarify 1) whether Young's modulus measured by shear wave elastography more reflects "structural factors" such as the structure of blood vessel walls or "functional factors" such as vascular reactivity and 2) the physiological factors that influence Young's modulus. We found that the changes in estradiol during menstrual cycle in the young women and acute aerobic exercise did not affect Young's modulus. These results suggest that arterial stiffness measured by shear wave elastography may more reflect arterial structural factors compared to the functional factors.

Academic Significance and Societal Importance of the Research Achievements

動脈スティフネスは心血管疾患の発症リスクとの関連が強く,その評価は臨床的意義が高い.ただし,従来から用いられている動脈スティフネスの指標は,運動,エストロゲンなどのホルモンの影響,血圧,食事,緊張などの影響を受けやすいことが報告されており,動脈硬化検査にて考慮すべき問題である.これに対して,剪断波エラストグラフィは,機能的要素の影響を受けにくく,かつ局所の器質的な硬さを非侵襲的に測定できることが示され,心血管疾患予防のための有用なツールとなる可能性が示された.

Report

(6 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (24 results)

All 2021 2020 2019 2018 2017 2016 Other

All Int'l Joint Research (1 results) Journal Article (18 results) (of which Int'l Joint Research: 12 results,  Peer Reviewed: 17 results,  Open Access: 4 results,  Acknowledgement Compliant: 1 results) Presentation (5 results) (of which Int'l Joint Research: 4 results,  Invited: 1 results)

  • [Int'l Joint Research] University of Iowa(米国)

    • Related Report
      2016 Research-status Report
  • [Journal Article] Greater increase in internal carotid artery shear rate during aerobic interval compared to continuous exercise in healthy adult men2021

    • Author(s)
      Ogoh Shigehiko、Washio Takuro、Suzuki Kazuya、Iemitsu Motoyuki、Hashimoto Takeshi、Iwamoto Erika、Bailey Damian M.
    • Journal Title

      Physiological Reports

      Volume: 9 Issue: 2

    • DOI

      10.14814/phy2.14705

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Effects of menstrual cycle and menopause on internal carotid artery shear-mediated dilation in women2021

    • Author(s)
      Iwamoto Erika、Sakamoto Rintaro、Tsuchida Wakako、Yamazaki Kotomi、Kamoda Tatsuki、Neki Toru、Katayose Masaki、Casey Darren P.
    • Journal Title

      American Journal of Physiology-Heart and Circulatory Physiology

      Volume: 320 Issue: 2 Pages: H679-H689

    • DOI

      10.1152/ajpheart.00810.2020

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Fluctuating shear during resistance exercise.2020

    • Author(s)
      Erika Iwamoto, Shigehiko Ogoh
    • Journal Title

      Experimental Physiology

      Volume: 105 Issue: 12 Pages: 2004-2006

    • DOI

      10.1113/ep089174

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of Age and Acute Exercise on Circulating Angioregulatory Factors2020

    • Author(s)
      Luttrell Meredith J.、Mardis Benjamin R.、Bock Joshua M.、Iwamoto Erika、Hanada Satoshi、Ueda Kenichi、Feider Andrew J.、Temperly Kenzie、Casey Darren
    • Journal Title

      Journal of Aging and Physical Activity

      Volume: 22 Issue: 3 Pages: 1-8

    • DOI

      10.1123/japa.2020-0024

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Greater α1-adrenergic-mediated vasoconstriction in contracting skeletal muscle of patients with type 2 diabetes2020

    • Author(s)
      Bock Joshua M.、Hughes William E.、Ueda Kenichi、Feider Andrew J.、Hanada Satoshi、Kruse Nicholas T.、Iwamoto Erika、Casey Darren P.
    • Journal Title

      American Journal of Physiology-Heart and Circulatory Physiology

      Volume: 319 Issue: 4 Pages: H797-H807

    • DOI

      10.1152/ajpheart.00532.2020

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Intermittent hypoxia enhances shear-mediated dilation of the internal carotid artery in young adults2020

    • Author(s)
      Iwamoto Erika、Hanson Brady E.、Bock Joshua M.、Casey Darren P.
    • Journal Title

      Journal of Applied Physiology

      Volume: 129 Issue: 3 Pages: 603-611

    • DOI

      10.1152/japplphysiol.00274.2020

    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Journal Article] Aerobic exercise offsets endothelial dysfunction induced by repetitive consumption of sugar-sweetened beverages in young healthy men2020

    • Author(s)
      Bock Joshua M.、Iwamoto Erika、Horak Jeffrey G.、Feider Andrew J.、Hanada Satoshi、Casey Darren P.
    • Journal Title

      American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

      Volume: 319 Issue: 1 Pages: R11-R18

    • DOI

      10.1152/ajpregu.00055.2020

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Habitual cigarette smoking attenuates shear‐mediated dilation in the brachial artery but not in the carotid artery in young adults2020

    • Author(s)
      Suzuki Kazuya, Washio Takuro, Tsukamoto Shingo, Kato Kazunori, Iwamoto Erika, Ogoh Shigehiko
    • Journal Title

      Physiological Reports

      Volume: 8 Issue: 3

    • DOI

      10.14814/phy2.14369

    • Related Report
      2020 Annual Research Report 2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Acute Hypotension Attenuates Brachial Flow-Mediated Dilation in Young Healthy Men2020

    • Author(s)
      Erika Iwamoto、Yutaka Yamada、Masaki Katayose、Rintaro Sakamoto、Toru Neki、Jun Sugawara、Shigehiko Ogoh
    • Journal Title

      European Journal of Applied Physiology

      Volume: 120 Issue: 1 Pages: 161-169

    • DOI

      10.1007/s00421-019-04260-0

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effects of Respiratory Muscle Endurance Training in Hypoxia on Running Performance2019

    • Author(s)
      Katayama Keisho、Goto Kazushige、Ohya Toshiyuki、Iwamoto Erika、Takao Kenji、Kasai Nobukazu、Sumi Daichi、Mori Hisashi、Ishida Koji、Shimizu Kaori、Shiozawa Kana、Suzuki Yasuhiro
    • Journal Title

      Medicine & Science in Sports & Exercise

      Volume: in press Issue: 7 Pages: 1477-1486

    • DOI

      10.1249/mss.0000000000001929

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Neuromuscular electrical stimulation increases serum brain-derived neurotrophic factor in humans2018

    • Author(s)
      Kimura Takehide、Kaneko Fuminari、Iwamoto Erika、Saitoh Shigeyuki、Yamada Takashi
    • Journal Title

      Experimental Brain Research

      Volume: 237 Issue: 1 Pages: 47-56

    • DOI

      10.1007/s00221-018-5396-y

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Hypercapnia-induced shear-mediated dilation in the internal carotid artery is blunted in healthy older adults2018

    • Author(s)
      Iwamoto Erika、Bock Joshua M.、Casey Darren P.
    • Journal Title

      American Journal of Physiology-Heart and Circulatory Physiology

      Volume: 315 Issue: 5 Pages: H1279-H1286

    • DOI

      10.1152/ajpheart.00335.2018

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Impaired modulation of postjunctional α1- but not α2-adrenergic vasoconstriction in contracting forearm muscle of postmenopausal women2018

    • Author(s)
      Kruse Nicholas T.、Hughes William E.、Ueda Kenichi、Hanada Satoshi、Feider Andrew J.、Iwamoto Erika、Bock Joshua M.、Casey Darren P.
    • Journal Title

      The Journal of Physiology

      Volume: 596 Issue: 13 Pages: 2507-2519

    • DOI

      10.1113/jp275777

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Blunted shear-mediated dilation of the internal but not common carotid artery in response to lower body negative pressure2018

    • Author(s)
      Iwamoto Erika、Bock Joshua M.、Casey Darren P.
    • Journal Title

      Journal of Applied Physiology

      Volume: 124 Issue: 5 Pages: 1326-1332

    • DOI

      10.1152/japplphysiol.01011.2017

    • Related Report
      2018 Research-status Report 2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] High-Intensity Exercise Enhances Conduit Artery Vascular Function in Older Adults2018

    • Author(s)
      IWAMOTO ERIKA、BOCK JOSHUA M.、CASEY DARREN P.
    • Journal Title

      Medicine & Science in Sports & Exercise

      Volume: 50 Issue: 1 Pages: 124-130

    • DOI

      10.1249/mss.0000000000001405

    • Related Report
      2018 Research-status Report 2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Evidence of a greater functional sympatholysis in habitually aerobic trained postmenopausal women2018

    • Author(s)
      Kruse Nicholas T.、Hughes William E.、Hanada Satoshi、Ueda Kenichi、Bock Joshua M.、Iwamoto Erika、Casey Darren P.
    • Journal Title

      Journal of Applied Physiology

      Volume: 124 Issue: 3 Pages: 583-591

    • DOI

      10.1152/japplphysiol.00411.2017

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Acute vascular effects of carbonated warm water lower leg immersion in healthy young adults.2016

    • Author(s)
      Ogoh S, Nagaoka R,Mizuno T, Kimura S, Shidahara Y, Ishii T, Kudoh M, Iwamoto E.
    • Journal Title

      Physiological Reports

      Volume: 4(23) Issue: 23 Pages: e13046-e13046

    • DOI

      10.14814/phy2.13046

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Blunted blood pressure response during hyperpnoea in endurancerunners2016

    • Author(s)
      Itoh Yuka/Katayama Keisho/Iwamoto Erika/Goto Kazushige/Suzuki Yasuhiro/Ohya Toshiyuki/Takao Kenji/Ishida Koji
    • Journal Title

      Respiratory Physiology & Neurobiology

      Volume: 230 Pages: 22-28

    • DOI

      10.1016/j.resp.2016.04.010

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Presentation] Hypercapnia-induced shear-mediated dilation in the internal carotid arteries is blunted in healthy older adults2018

    • Author(s)
      Iwamoto Erika、Bock Joshua M.、Casey Darren P.
    • Organizer
      Experimental Biology
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Effects of shear stress during exercise on the vascular endothelial function2018

    • Author(s)
      Iwamoto Erika
    • Organizer
      第95回日本生理学会
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] Sympathetic nervous system activation attenuates shear-mediated dilation in the internal carotid artery of young adults2017

    • Author(s)
      Iwamoto Erika、Bock Joshua M.、Casey Darren P.
    • Organizer
      Iowa Physiological Society Meeting
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Combined effect of heating and electrical stimulation on endothelial vasodilator function2017

    • Author(s)
      Iwamoto Erika、Takami Jiro、Nagaoka Ryohei、Neki Toru、Katayose Masaki.
    • Organizer
      Experimental Biology
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Variations Of Carotid Arterial Elasticity During The Menstrual Cycle Using Ultrasound Shear Wave Elastography2016

    • Author(s)
      Iwamoto E, Minakami M, Nagaoka R, Neki T, Taniguchi K, Katayose M
    • Organizer
      American College of Sports Medicine
    • Place of Presentation
      Boston、USA
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research

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Published: 2016-04-21   Modified: 2022-02-16  

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