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Development of rehabilitation technique to induce inhibitory neural activity in patients with focal hand dystonia

Research Project

Project/Area Number 16K16433
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Rehabilitation science/Welfare engineering
Research InstitutionIbaraki Prefectural University of Health Science

Principal Investigator

Aoyama Toshiyuki  茨城県立医療大学, 保健医療学部, 助教 (30516571)

Research Collaborator KOHNO Yutaka  
TOMITA Kazuhide  
KANEKO Fuminari  
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2018: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2016: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords抑制性神経活動 / フォーカルハンドジストニア / 経頭蓋磁気刺激 / F波 / 抑制性神経機構 / 運動イメージ想起 / 運動観察 / 抑制性神経回路 / 経頭蓋直流電気刺激
Outline of Final Research Achievements

Focal hand dystonia is a disabling movement disorder that often occurs in musicians who use hand repeatedly and effective rehabilitation has not yet been established. Some previous studies revealed that this symptom is associated with impaired inhibitory neural activity. Therefore, we examined neurophysiological changes induced by motor imagery to verify whether motor imagery is effective as a treatment to promote inhibitory neural activity. As a result, we found inhibitory effects on the neural activity of the antagonist muscle during motor imagery. These results suggest that the possibility of motor imagery for the treatment of focal hand dystonia. In the future, we have to verify the effect of motor imagery therapy on the focal hand dystonia patients.

Academic Significance and Societal Importance of the Research Achievements

本研究は,運動を脳内でイメージすることで,脳の抑制性の神経活動が促されることを示した初めての研究である。神経疾患の中には,フォーカルハンドジストニアだけでなく,脳卒中の痙縮など,抑制性の神経活動に問題が生じた結果として生じる障害が存在する。本研究成果は,そのような障害に対する新しいリハビリテーション手法として運動イメージ想起という方法が有用な可能性を示しており,今後の臨床研究成果が期待される。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (9 results)

All 2019 2018 2017 2016

All Journal Article (4 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 4 results,  Open Access: 1 results) Presentation (5 results)

  • [Journal Article] Development of an educational program for interprofessional collaboration: A workshop approach involving undergraduates from multiple departments2019

    • Author(s)
      Setaka Y, Tomita K, Aoyama T, Sekimoto M, Aita Y, Ohashi Y, Ninomiya
    • Journal Title

      Journal of Allied Health Sciences

      Volume: 10 Pages: 10-18

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Analysis of reaching movements in stroke patients using average variability of electromyogram value2017

    • Author(s)
      Tatsunori Sawada, Fuminari Kaneko, Toshiyuki Aoyama, Masahiro Ogawa, Tsuneji Murakami
    • Journal Title

      Asian Journal of Occupational Therapy

      Volume: 13 Pages: 13-21

    • NAID

      130005683111

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Surround inhibition in motor execution and motor imagery2016

    • Author(s)
      Aoyama T, Kaneko F, Ohashi Y, Nagata F
    • Journal Title

      Neurocsi Lett

      Volume: 629 Pages: 196-201

    • DOI

      10.1016/j.neulet.2016.07.012

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] The association of motor imagery and kinesthetic illusion prolong the effect of transcranial direct current stimulation on corticospinal tract excitability2016

    • Author(s)
      Kaneko, F., Shibata, E., Hayami, T., Nagahata, K., Aoyama, T
    • Journal Title

      Journal of NeuroEngineering and Rehabilitation

      Volume: 13 Issue: 1 Pages: 36-43

    • DOI

      10.1186/s12984-016-0143-8

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] 上肢感覚性運動失調を併発した脳卒中片麻痺患者に対する 視覚誘導性自己運動錯覚の即時効果 ~運動学的評価と神経生理学的評価を用いた検証~2018

    • Author(s)
      加藤 淳史,青山 敏之,河野 豊,冨田 和秀,渡邉 信也,遠藤 悠介,金子 文成
    • Organizer
      第23回日本基礎理学療法学会学術大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 重度運動麻痺を呈した慢性期脳卒中片麻痺患者の手指機能に対する視覚性自己運動錯覚の即時的効果~経頭蓋磁気刺激を用いた運動機能改善のメカニズムの検証2018

    • Author(s)
      加藤淳史, 青山敏之, 河野豊, 冨田和秀, 渡邉信也, 遠藤悠介, 金子文成
    • Organizer
      第22回茨城県理学療法士学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Stiff Knee Gait を呈した症例における歩行時ハムストリングス筋活動の特徴2017

    • Author(s)
      真庭弘樹,青山敏之
    • Organizer
      第36回関東甲信越ブロック理学療法士学会(長野)
    • Related Report
      2017 Research-status Report
  • [Presentation] 運動イメージ想起によって拮抗筋を支配する皮質・脊髄に生じる興奮性変化2016

    • Author(s)
      青山 敏之, 金子 文成, 大橋 ゆかり
    • Organizer
      第10回Motor Control研究会
    • Place of Presentation
      横浜
    • Year and Date
      2016-09-01
    • Related Report
      2016 Research-status Report
  • [Presentation] 運動遂行と運動イメージ想起がもたらす皮質脊髄路への抑制性入力の相違2016

    • Author(s)
      青山 敏之, 金子 文成, 大橋 ゆかり
    • Organizer
      第51回日本理学療法学術大会
    • Place of Presentation
      札幌
    • Year and Date
      2016-05-27
    • Related Report
      2016 Research-status Report

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Published: 2016-04-21   Modified: 2020-03-30  

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