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Tactile stimulation elicits 50-kHz ultrasonic vocalizations in rats

Research Project

Project/Area Number 16K16439
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Rehabilitation science/Welfare engineering
Research InstitutionInternational University of Health and Welfare

Principal Investigator

Shimoju Rie  国際医療福祉大学, 基礎医学研究センター, 講師 (10433624)

Project Period (FY) 2016-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2018: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords触刺激 / 超音波発声 / 情動 / 動機づけ / 側坐核 / ドーパミン / セロトニン / オピオイド / ラット / 快情動 / マイクロダイアリシス / ナロキソン / リハビリテーション / 生理学 / 動物
Outline of Final Research Achievements

The effects and neural mechanisms of manual therapy using various tactile stimulation have yet to be clarified. We have previously shown that tactile stimulation can change the neural transmission in the nucleus accumbens, playing pivotal role in positive emotion. This study investigated the neural mechanisms involving generation of emotional change to tactile stimulation. Rats emit 50-kHz ultrasonic vocalizations (50-kHz USVs) in positive emotional state. The recordings of 50-kHz ultrasonic vocalizations emitted by rat were used to evaluate the call rate, indicating positive emotion. Rats emitted abundant 50-kHz USVs to tactile stimulation. Accumbal dopamine release were increased by tactile stimulation via 5-HT and opioid receptor in the nucleus accumbens. Emission of 50-kHz USVs to tactile stimulation were induced by accumbal dopamine release. These findings suggest that tactile stimulation may induce positive emotions through the activation of nucleus accumbens.

Academic Significance and Societal Importance of the Research Achievements

本研究より、触刺激がモチベーションと関わる脳部位の神経伝達機能を変えることが明らかになった。さらに、触刺激によってラットが快情動状態となることが明らかとなり、触刺激が実際に快情動中枢の神経伝達機能を変えて、快情動を発現させる可能性が示された。本研究は、触刺激が対象者のリハビリへの動機付け、意欲向上に貢献する可能性を示すものであり、リハビリにおける触刺激の効果の科学的根拠の一つを示すものである。

Report

(5 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (41 results)

All 2019 2018 2017 2016

All Journal Article (18 results) (of which Peer Reviewed: 18 results,  Acknowledgement Compliant: 1 results) Presentation (23 results) (of which Int'l Joint Research: 7 results,  Invited: 1 results)

  • [Journal Article] 後肢足蹠侵害性機械的刺激時のラット昇圧反応における外側腕傍核の関与2019

    • Author(s)
      野澤羽奈,下重里江,谷口敬道,柴田秀史,黒澤美枝子
    • Journal Title

      自律神経

      Volume: 56 Pages: 80-87

    • NAID

      130007672264

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 若年健常女性における背部への軽擦並びに温熱刺激が心拍数におよぼす影響とその自律神経機序2019

    • Author(s)
      半田直子,下重里江,目黒和子,黒澤美枝子
    • Journal Title

      自律神経

      Volume: 56 Pages: 1-10

    • NAID

      130007718951

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 痛みと情動・自律反応 扁桃体中心核セロトニン放出におよぼす皮膚への侵害性機械的刺激の影響2019

    • Author(s)
      黒澤 美枝子,徳永 亮太,下重 里江
    • Journal Title

      自律神経

      Volume: 56 Pages: 128-131

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 体性感覚刺激がラット快情動超音波発声におよぼす影響とその脳内メカニズムの解明2019

    • Author(s)
      下重里江,柴田秀史,黒澤美枝子
    • Journal Title

      国際医療福祉大学学会誌(第9回国際医療福祉大学学会学術大会抄録号)

      Volume: 24 Pages: 153-153

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 皮膚刺激時の扁桃体セロトニン放出反応における求心性機構の解明2019

    • Author(s)
      黒澤美枝子,徳永亮太,下重里江
    • Journal Title

      国際医療福祉大学学会誌(第9回国際医療福祉大学学会学術大会抄録号)

      Volume: 24 Pages: 155-155

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 動脈圧・心拍数におよぼす温熱棒刺激の影響とその自律神経性機序 ラットを用いたイトオテルミー療法効果の基礎検討2019

    • Author(s)
      下重 里江,小林 和花子,江幡 芳枝,黒澤 美枝子
    • Journal Title

      自律神経

      Volume: 56

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Massage-like stroking stimulation induces 50-kHz ultrasonic vocalizations2019

    • Author(s)
      Shimoju R, Hori M, Shibata H, Kurosawa M
    • Journal Title

      The Journal of Physiological Sciences

      Volume: 69

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of the lateral parabrachial nucleus in the pressor responses to pinching of the hindpaw2019

    • Author(s)
      Nozawa H, Shimoju R, Taniguchi T, Shibata H, Kurosawa M
    • Journal Title

      The Journal of Physiological Sciences

      Volume: 69

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 後肢足蹠侵害性機械的刺激時のラット昇圧反応における外側腕傍核の関与2019

    • Author(s)
      野澤羽奈、下重里江、谷口敬道、柴田秀史、黒澤美枝子
    • Journal Title

      自律神経

      Volume: 56

    • NAID

      130007672264

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] 鍼・マッサージ、温熱刺激の効果とその科学的根拠 ラット側坐核並びに扁桃体中心核での神経伝達物質放出におよぼす体性感覚刺激の影響2018

    • Author(s)
      黒澤美枝子、下重里江、徳永亮太
    • Journal Title

      自律神経

      Volume: 55 Pages: 242-245

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] 温熱棒を用いたマッサージ様皮膚刺激によるラットの動脈圧・心拍数反応とその機序─イトオテルミー療法効果の基礎検討─2018

    • Author(s)
      藤田和花子,下重里江,江幡芳江,黒澤美枝子
    • Journal Title

      自律神経

      Volume: 55 Pages: 38-45

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Somatosensory regulation of serotonin release in the central nucleus of the amygdala is mediated via corticotropinreleasing factor and gamma-aminobutyric acid in the dorsal raphe nucleus.2017

    • Author(s)
      Tokunaga R, Shimoju R, Shibata H, Kurosawa M
    • Journal Title

      The Journal of Physiological Sciences

      Volume: 印刷中 Issue: 6 Pages: 689-698

    • DOI

      10.1007/s12576-016-0498-4

    • NAID

      40021363384

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] 自律神経と体内環境 閉経モデル動物における骨格筋刺激時の動脈圧反応2017

    • Author(s)
      下重里江,黒澤美枝子
    • Journal Title

      自律神経

      Volume: 54 Pages: 294-294

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] The contribution of 5-HT3 receptors to responses of dopamine release in the nucleus accumbens to tactile stimulation in rats2017

    • Author(s)
      Shimoju R, Makita S, Shibata H, Kurosawa M
    • Journal Title

      The Journal of Physiological Sciences

      Volume: 67

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] The contribution of 5-HT3 receptors to responses of dopamine release in the nucleus accumbens to tactile stimulation in rats.2017

    • Author(s)
      Shimoju R, Makita S, Shibata H, Kurosawa M
    • Journal Title

      The Journal of Physiological Sciences

      Volume: 67

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Serotonin release in the central nucleus of the amygdala in response to noxious and innocuous cutaneous stimulation in anesthetized rats.2016

    • Author(s)
      Tokunaga R, Shimoju R, Takagi N, Shibata H, Kurosawa M
    • Journal Title

      The Journal of Physiological Sciences

      Volume: 66 Issue: 4 Pages: 307-314

    • DOI

      10.1007/s12576-015-0426-z

    • NAID

      40020868107

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] ラットの腹部皮膚触刺激時の動脈圧・心拍数低下反応における自律神経性機序2016

    • Author(s)
      今井 樹,下重里江,徳永亮太,黒澤美枝子
    • Journal Title

      自律神経

      Volume: 53 Pages: 253-259

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] コルチコトロピン放出因子受容体遮断薬の脳室内投与がピンチ刺激時の動脈圧・心拍数反応におよぼす影響2016

    • Author(s)
      下重里江,徳永亮太,黒澤美枝子
    • Journal Title

      自律神経

      Volume: 53 Pages: 305-311

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Presentation] 背部への体性感覚刺激が心拍数に及ぼす影響とその自律神経機序2019

    • Author(s)
      下重里江,半田直子,目黒和子,黒澤美枝子
    • Organizer
      第72回日本自律神経学会総会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 後肢侵害刺激によって誘発されるラット昇圧反応におけるKolliker-Fuse核の関与2019

    • Author(s)
      野澤羽奈,下重里江,谷口敬道,柴田秀史,黒澤美枝子
    • Organizer
      第72回日本自律神経学会総会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 体性感覚刺激がラット快情動超音波発声におよぼす影響とその脳内メカニズムの解明2019

    • Author(s)
      下重里江,柴田秀史,黒澤美枝子
    • Organizer
      第9回国際医療福祉大学学会学術大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 皮膚刺激時の扁桃体セロトニン放出反応における求心性機構の解明2019

    • Author(s)
      黒澤美枝子,徳永亮太,下重里江
    • Organizer
      第9回国際医療福祉大学学会学術大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Massage-like stroking stimulation induces 50-kHz ultrasonic vocalizations2019

    • Author(s)
      Shimoju R, Hori M, Shibata H, Kurosawa M
    • Organizer
      9th Federation of the Asian and Oceanian Physiological Societies Congress
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Involvement of the lateral parabrachial nucleus in the pressor2019

    • Author(s)
      Nozawa H, Shimoju R, Taniguchi T, Shibata H, Kurosawa M
    • Organizer
      9th Federation of the Asian and Oceanian Physiological Societies Congress
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Massage-like stroking stimulation induces 50-kHz ultrasonic vocalizations2019

    • Author(s)
      Shimoju R, Hori M, Shibata H, Kurosawa M
    • Organizer
      9th Federation of the Asian and Oceanian Physiological Societies Congress
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Involvement of the lateral parabrachial nucleus in the pressor pressor responses to pinching of the hindpaw2019

    • Author(s)
      Nozawa H, Shimoju R, Taniguchi T, Shibata H, Kurosawa M
    • Organizer
      9th Federation of the Asian and Oceanian Physiological Societies Congress
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] 後肢侵害刺激によって誘発されるラットの昇圧反応ー外側腕傍核の関与ー2018

    • Author(s)
      野澤羽奈,下重里江,黒澤美枝子
    • Organizer
      第46回自律神経生理研究会
    • Related Report
      2018 Research-status Report
  • [Presentation] 動脈圧・心拍数におよぼす温熱棒刺激の影響とその自律神経性機序 ーラットを用いたイトオテルミー療法効果の基礎検討ー2018

    • Author(s)
      下重里江,小林和花子,江端芳江,黒澤美枝子
    • Organizer
      第71回日本自律神経学会総会
    • Related Report
      2018 Research-status Report
  • [Presentation] 後肢侵害刺激時のラット昇圧反応における外側腕傍核の関与2018

    • Author(s)
      野澤羽奈,下重里江,柴田秀史,黒澤美枝子
    • Organizer
      第71回日本自律神経学会総会
    • Related Report
      2018 Research-status Report
  • [Presentation] 体性感覚刺激時のラット側坐核ドーパミン放出におけるオピオイドの関与2018

    • Author(s)
      下重里江,柴田秀史,黒澤美枝子
    • Organizer
      第8回国際医療福祉大学学会
    • Related Report
      2018 Research-status Report
  • [Presentation] 情動がアロデニアにおよぼす影響の脳内機序2018

    • Author(s)
      黒澤美枝子,徳永亮太,柴田秀史,下重里江
    • Organizer
      第8回国際医療福祉大学学会
    • Related Report
      2018 Research-status Report
  • [Presentation] 触刺激時の側坐核ドーパミン放出に対するセロトニン3受容体遮断薬の影響2017

    • Author(s)
      下重里江,蒔田祥子,柴田秀史,黒澤美枝子
    • Organizer
      第94回日本生理学会大会
    • Place of Presentation
      浜松アクトシティコングレスセンター(静岡県浜松市)
    • Year and Date
      2017-03-28
    • Related Report
      2016 Research-status Report
  • [Presentation] Influence of somatic afferent stimulation on neurotransmitter release in the nucleus accumbens and the central nucleus of amygdala in rats2017

    • Author(s)
      Kurosawa M, Shimoju R, Tokunaga R
    • Organizer
      ISAN 2017/JSNR2017
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Neural mechanisms of cardiovascular responses to stroking of the acumen in anesthetized rats2017

    • Author(s)
      Shimoju R, Imai I, Tokunaga R, Makita S, Kurosawa M
    • Organizer
      ISAN 2017/JSNR2017
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Responses of blood pressure to stroking of the slkin in healthy young subjects under the condition of elevated sympathetic nervous system2017

    • Author(s)
      Arimoto K, Shimoju R, Kurosawa M
    • Organizer
      ISAN 2017/JSNR2017
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] 体性感覚刺激時のラット側坐核ドーパミン放出におよぼす同核セロトニンの関与2017

    • Author(s)
      下重里江,蒔田祥子,柴田秀史,黒澤美枝子
    • Organizer
      第7回国際医療福祉大学学会
    • Related Report
      2017 Research-status Report
  • [Presentation] 侵害性皮膚刺激時の自律機能,内分泌機能,情動の変化における脳内コルチコトロピン放出因子の関与2017

    • Author(s)
      黒澤美枝子,下重里江
    • Organizer
      第7回国際医療福祉大学学会
    • Related Report
      2017 Research-status Report
  • [Presentation] 閉経モデル動物における骨格筋刺激時の動脈圧反応2016

    • Author(s)
      下重里江,黒澤美枝子
    • Organizer
      第69回日本自律神経学会総会
    • Place of Presentation
      くまもと県民交流館パレア(熊本県熊本市)
    • Year and Date
      2016-11-10
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] 体性感覚刺激がラット側坐核セロトニン放出におよぼす影響とそのメカニズム2016

    • Author(s)
      下重里江,蒔田祥子,柴田秀史,黒澤美枝子
    • Organizer
      第6回国際医療福祉大学学会
    • Place of Presentation
      国際医療福祉大学(栃木県大田原市)
    • Year and Date
      2016-08-27
    • Related Report
      2016 Research-status Report
  • [Presentation] 慢性疼痛モデル動物における体性感覚刺激時の扁桃体セロトニン放出反応の検討2016

    • Author(s)
      黒澤美枝子,徳永亮太,下重里江,柴田秀史
    • Organizer
      第6回国際医療福祉大学学会
    • Place of Presentation
      国際医療福祉大学(栃木県大田原市)
    • Year and Date
      2016-08-27
    • Related Report
      2016 Research-status Report
  • [Presentation] 皮膚への機械的刺激によるラット扁桃体中心核セロトニン放出変化2016

    • Author(s)
      徳永亮太,下重里江,柴田秀史,黒澤美枝子
    • Organizer
      第39回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-07-20
    • Related Report
      2016 Research-status Report

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Published: 2016-04-21   Modified: 2021-02-19  

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