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Development and validation of neuroprosthesis to enhance memory consolidation of motor learning

Research Project

Project/Area Number 16K16467
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Rehabilitation science/Welfare engineering
Research InstitutionNational Center for Geriatrics and Gerontology (2017-2018)
Keio University (2016)

Principal Investigator

KATO Kenji  国立研究開発法人国立長寿医療研究センター, 健康長寿支援ロボットセンター, 室長 (30771216)

Research Collaborator TAKAHASHI Kensho  
MIZUGUCHI Nobuaki  
USHIBA Junichi  
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2018: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywordsブレイン・コンピュータ・インターフェース / 神経補綴装置 / 頭皮脳波 / 事象関連脱同期 / リハビリテーション / ブレイン・マシーン・インターフェース / 経頭蓋磁気刺激法 / Neural Prosthesis / Brain-Computer Interface / 随意運動制御 / 運動機能再建 / 脳卒中片麻痺 / 脳波 / 睡眠 / 学習記憶定着 / 脳卒中
Outline of Final Research Achievements

Neurofeedback of event-related desynchronizations (ERDs) in electroencephalograms (EEG) of the sensorimotor cortex (SM1) is a powerful tool to promote motor recovery from post-stroke hemiplegia. The present study developed the online estimation algorithm of the motor-related alpha and beta SM1-ERDs using a lock-in amplifier (LIA) for the purpose to enhance motor learning and neural plasticity. The LIA improved the detection delay, accuracy, and stability for estimating amplitude modulation of motor-related SM1-ERDs compared to conventional fast Fourier transformation (FFT) based algorithm. The present study also demonstrated that the calculation of the motor-related SM1-ERDs using the novel online LIA led to more accurate estimation of corticospinal excitability than when ordinary FFT based algorithm is used.

Academic Significance and Societal Importance of the Research Achievements

ブレイン・コンピュータ・インターフェース(BCI)を用いたリハビリテーションは、脳梗塞患者における運動機能回復を促進することが示唆されてきた。BCIのパラダイムでは、大脳皮質一次運動野の活動依存的に電動装具や神経筋電気刺激を与えることが、運動学習や学習記憶を促すために必須と考えられる。したがって、本研究で得られたロックインアンプによる脳波振幅推定アルゴリズムが、その推定時間・精度・正確度の点で有意な改善を示せたという結果は、運動麻痺に対するBCIを用いたリハビリテーションの効果を促進できる可能性を支持する結果と考える。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (5 results)

All 2018 2016 Other

All Int'l Joint Research (2 results) Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 2 results) Presentation (1 results) (of which Invited: 1 results)

  • [Int'l Joint Research] コペンハーゲン大学(デンマーク)

    • Related Report
      2016 Research-status Report
  • [Int'l Joint Research]

    • Related Report
      2016 Research-status Report
  • [Journal Article] Precise estimation of human corticospinal excitability associated with the levels of motor imagery-related EEG desynchronization extracted by a locked-in amplifier algorithm.2018

    • Author(s)
      Takahashi K, Kato K, Mizuguchi N, Ushiba J
    • Journal Title

      J Neuroeng Rehabil.

      Volume: 15(93) Issue: 1 Pages: 1-9

    • DOI

      10.1186/s12984-018-0440-5

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Online detection of amplitude modulation of motor-related EEG desynchronization using a lock-in amplifier: Comparison with a fast Fourier transform, a continuous wavelet transform, and an autoregressive algorithm.2018

    • Author(s)
      Kato K, Takahashi K, Mizuguchi N, Ushiba J.
    • Journal Title

      J Neurosci Methods.

      Volume: 293 Pages: 289-298

    • DOI

      10.1016/j.jneumeth.2017.10.015

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 脳損傷後における人工神経再配線による運動機能の補綴2016

    • Author(s)
      加藤健治
    • Organizer
      第8回 神経科学・リハビリテーション・ロボット工学のシナジー効果に関する研究会
    • Place of Presentation
      東北医科薬科大学
    • Related Report
      2016 Research-status Report
    • Invited

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Published: 2016-04-21   Modified: 2020-03-30  

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