The role of corticotropin releasing hormone in acquisition of motor learning

Research Project

Project/Area Number	16K16486
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Developmental mechanisms and the body works
Research Institution	National Center of Neurology and Psychiatry
Principal Investigator	TAKEUCHI Eri 国立研究開発法人国立精神・神経医療研究センター, 神経研究所疾病研究第四部, 流動研究員 (70712777)
Project Period (FY)	2016-04-01 – 2018-03-31
Project Status	Completed (Fiscal Year 2017)
Budget Amount *help	¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000) Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000) Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords	コルチコトロピン放出ホルモン / 運動学習
Outline of Final Research Achievements	In our previous study, we found that the acquisition of motor learning was enhanced by injection of corticotropin releasing hormone (CRH) into the cerebellum. It suggests that exogenous CRH enhances the acquisition of motor learning. In this study, we focused on the role of endogenous CRH in the acquisition of motor learning. We found that CRH mRNA in the cerebellum was increased after the mice were received restraint stress. Moreover, the mice received restraint stress showed enhanced acquisition of motor learning. These results suggest that endogenous CRH also has a positive effect on motor learning.

Report

(3 results)