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Peak oxygen uptake, muscle oxygen dynamics, and heart function in knee osteoarthritis

Research Project

Project/Area Number 16K16487
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Developmental mechanisms and the body works
Research InstitutionDoshisha University (2017-2018)
Waseda University (2016)

Principal Investigator

Takagi Shun  同志社大学, スポーツ健康科学部, 助教 (80735415)

Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2018: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2017: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2016: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Keywords運動器疾患 / 骨格筋酸素ダイナミクス / 筋代謝 / 中心循環 / 有酸素能 / 全身運動 / 中高齢者 / 過体重 / 酸素ダイナミクス / 骨格筋代謝 / 変形性関節症 / 心拍出量 / 最大酸素摂取量 / 骨格筋 / 末梢循環
Outline of Final Research Achievements

The aim of this study was to investigate the muscle deoxygenation and its relationship to peak VO2 in knee osteoarthritis (OA). Muscle deoxygenation during exercise was attenuated in knee OA than age-matched elderly subjects without knee OA. Moreover, the blunted muscle deoxygenation was correlated with lowered peak VO2. In addition, we test the effect of overweight on muscle deoxygenation and aerobic capacity. Muscle deoxygenation was minor in overweight than normal-weight adults, and the lowered muscle deoxygenation was related to reduced peak VO2 in overweight adults.

Academic Significance and Societal Importance of the Research Achievements

最大酸素摂取量の低下は変形性膝関節症患者(膝OA)における動脈硬化性疾患の発症リスクを増大させる一方で,国内外における膝OA 患者数は既に多く、高齢化社会の進行により運動器疾患患者数は今後も増大していくと考えられる。本研究では、骨格筋の循環と代謝の観点から、膝OAにおける最大酸素摂取量の低下のメカニズムを検討し、膝OAにおいては骨格筋における酸素利用能が低下が最大酸素摂取量の低下と関連することを明らかにした。本研究の成果は運動器疾患患者における骨格筋代謝改善の重要性を示唆している。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (7 results)

All 2019 2018 2017 2016

All Journal Article (4 results) (of which Peer Reviewed: 4 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (3 results) (of which Int'l Joint Research: 1 results,  Invited: 1 results)

  • [Journal Article] Differences in muscle O2 dynamics during treadmill exercise between aerobic capacity-matched overweight and normal-weight adults2019

    • Author(s)
      Takagi S, Kime R, Midorikawa T, Niwayama M, Sakamoto S, Katsumura T
    • Journal Title

      Advances in Experimental Medicine and Biology

      Volume: -

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of Aerobic Cycling Training on O2 Dynamics in Several Leg Muscles in Early Post-Myocardial Infarction2018

    • Author(s)
      S. Takagi, R. Kime, N. Murase,M. Niwayama, T. Osada, and T. Katsumura
    • Journal Title

      Advances in Experimental Medicine and Biology

      Volume: 1072 Pages: 91-96

    • DOI

      10.1007/978-3-319-91287-5_15

    • ISBN
      9783319912851, 9783319912875
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Multi-site Measurements of Muscle O2 Dynamics During Cycling Exercise in Early Post-myocardial Infarction.2017

    • Author(s)
      Takagi S, Kime R, Murase N, Niwayama M, Osada T, Katsumura T
    • Journal Title

      Advances in Experimental Medicine and Biology

      Volume: 977 Pages: 35-41

    • DOI

      10.1007/978-3-319-55231-6_6

    • ISBN
      9783319552293, 9783319552316
    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Skeletal muscle oxygen dynamics and peak aerobic capacity2016

    • Author(s)
      Takagi S
    • Journal Title

      The Journal of Physical Fitness and Sports Medicine

      Volume: 5 Issue: 5 Pages: 379-383

    • DOI

      10.7600/jpfsm.5.379

    • NAID

      130005279664

    • ISSN
      2186-8123, 2186-8131
    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] Differences in muscle O2 dynamics during treadmill exercise between aerobic capacity-matched overweight and normal-weight adults.2018

    • Author(s)
      1)Takagi S, Kime R, Midorikawa T, Niwayama M, Sakamoto S, Katsumura T
    • Organizer
      46th International Society on Oxygen Transport to Tissue
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 過体重成人の筋酸素飽和度と最高酸素摂取量との関連における部位差2018

    • Author(s)
      高木俊,木目良太郎,緑川泰史,坂本静男,勝村俊仁
    • Organizer
      第73回日本体力医学会大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] NIRSを用いた運動療法の効果判定:心疾患患者の骨格筋における検討2018

    • Author(s)
      高木俊
    • Organizer
      第22回酸素ダイナミクス研究会
    • Related Report
      2018 Annual Research Report
    • Invited

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Published: 2016-04-21   Modified: 2020-03-30  

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