Mechanisms of sweat glands adaptation to exercise training: roles of neurotransmitters

• Project/Area Number: 16K16521
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Sports science
• Research Institution: Niigata University
• Principal Investigator: Amano Tatsuro 新潟大学, 人文社会科学系, 准教授 (60734522)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2016: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 体温調節 / エクリン汗腺 / 皮膚血流 / 発汗 / 熱中症 / 運動トレーニング / 薬理学 / 一酸化窒素 / アドレナリン / 皮膚血流量 / シクロオキシゲナーゼ / 皮内マイクロダイアリシス / マイクロダイアリシス

Outline of Final Research Achievements

We have firstly reported that the nitric oxide- and adrenaline-related mechanisms would contribute to high sweating function in habitually trained individuals. This study provides new insights for understanding human thermoregulation during exercise and hot environment and will contribute to preventions for heat related illness during the summer.

Research Products

• [Int'l Joint Research] University of Ottawa(カナダ)
• [Int'l Joint Research] オタワ大学(カナダ)
• [Journal Article] Do nitric oxide synthase and cyclooxygenase contribute to sweating response during passive heating in endurance-trained athletes? (2017)
  • Author(s): Amano T, Fujii N, Kenny GP, Inoue Y, and Kondo N.
  • Journal Title: Physiological Reports Volume: 5 Issue: 17 Pages: e13403-e13403
  • DOI: 10.14814/phy2.13403
  • NAID: 120007134807
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Evidence for β-adrenergic modulation of sweating during incremental exercise in habitually trained males. (2017)
  • Author(s): Amano T, Shitara Y, Fujii N, Tanaka S, Inoue Y, Kondo N.
  • Journal Title: J Appl Physiol Volume: 123 Issue: 1 Pages: 182-189
  • DOI: 10.1152/japplphysiol.00220.2017
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Individual variations in nitric oxide synthase-dependent sweating in young and older males during exercise in the heat: role of aerobic power (2017)
  • Author(s): Amano T, Fujii N, Louie JC, Meade RD, and Kenny GP.
  • Journal Title: Physiological Reports Volume: 5 Issue: 6
  • DOI: 10.14814/phy2.13208
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Mechanisms of nicotine-induced cutaneous vasodilation and sweating in young adults: roles for KCa, KATP, and KV channels, nitric oxide, and prostanoids (2017)
  • Author(s): Fujii N, Louie JC, McNeely BD, Amano T, Nishiyasu T, and Kenny GP.
  • Journal Title: Applied Physiology Nutrition and Metabolism Volume: 42 Issue: 5 Pages: 470-478
  • DOI: 10.1139/apnm-2016-0615
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Intradermal administration of endothelin-1 attenuates endothelium-dependent and -independent cutaneous vasodilation via Rho kinase in young adults (2017)
  • Author(s): Fujii N, Amano T, Halili L, Louie J, Zhang S, McNeely B, and Kenny GP
  • Journal Title: American Journal of Physiology Regulatory, Integrative and Comparative Physiology Volume: 312 Issue: 1 Pages: 23-30
  • DOI: 10.1152/ajpregu.00368.2016
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Sweating responses to isometric handgrip exercise and forearm muscle metaboreflex in prepubertal children and elderly. (2017)
  • Author(s): Amano T, Kai S, Nakajima M, Ichinose-Kuwahara T, Gerrett N, Kondo N, Inoue Y
  • Journal Title: Exp Physiol Volume: 102 Issue: 2 Pages: 214-227
  • DOI: 10.1113/ep085908
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Effect of stride frequency on thermoregulatory responses during endurance running in distance runners. (2016)
  • Author(s): Amano T, Ishitobi M, Ogura Y, Inoue Y, Koga S, Nishiyasu T, Kondo N
  • Journal Title: J Therm Biol Volume: 61 Pages: 61-66
  • DOI: 10.1016/j.jtherbio.2016.08.005
  • Peer Reviewed
• [Journal Article] Sex differences in age-related changes on peripheral warm and cold innocuous thermal sensitivity. (2016)
  • Author(s): Inoue Y, Gerrett N, Ichinose-Kuwahara T, Umino Y, Kiuchi S, Amano T, Havenith G, Ueda H, Kondo N
  • Journal Title: Physiol Behav Volume: 164(Pt A) Pages: 86-92
  • DOI: 10.1016/j.physbeh.2016.05.045
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Greater VO2peak is correlated with greater skeletal muscle deoxygenation amplitude and hemoglobin concentration within individual muscles during ramp-incremental cycle exercise. (2016)
  • Author(s): Okushima D, Poole DC, Barstow TJ, Rossiter HB, Kondo N, Bowen TS, Amano T, Koga S.
  • Journal Title: Physiol Rep Volume: 4 Issue: 23 Pages: 1-11
  • DOI: 10.14814/phy2.13065
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Presentation] Cutaneous adrenergic nerve blockade attenuates sweating response during incremental exercise in habitually trained and untrained men (2018)
  • Author(s): Tatsuro Amano, Naoto Fujii, Yoshimitsu Inoue, Narihiko Kondo
  • Organizer: Experimental Biology
  • Int'l Joint Research
• [Presentation] Characteristics of sweating response in habitually trained individuals and its potential mechanisms (2017)
  • Author(s): Tatsuro Amano and Narihiko Kondo
  • Organizer: International Conference on Environmental Ergonomics
  • Int'l Joint Research / Invited
• [Presentation] 運動トレーニング者における安静温熱負荷時の発汗反応：一酸化窒素とシクロオキシゲナーゼの影響 (2017)
  • Author(s): 天野 達郎，藤井 直人，井上 芳光，近藤 徳彦
  • Organizer: 日本体力医学会
• [Presentation] 局所的なβアドレナリン受容体阻害が 運動時の発汗反応に及ぼす影響 (2017)
  • Author(s): 天野 達郎，設楽 陽介
  • Organizer: 第31回運動と体温の研究会
• [Presentation] 精神性ストレスが筋代謝受容器活動時の熱放散反応に及ぼす影響 (2016)
  • Author(s): 天野 達郎，葺石 育美，白本 愛，井上 芳光， 西保 岳，近藤 徳彦
  • Organizer: 第71回日本体力医学会
  • Place of Presentation: いわて県民情報交流センター，盛岡市，岩手
  • Year and Date: 2016-09-22