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The effect of exercise to overcome stress and depression: Elucidation of a hippocampal molecular mechanism using RNA-Seq

Research Project

Project/Area Number 16K16559
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Sports science
Research InstitutionUniversity of Tsukuba

Principal Investigator

OKAMOTO Masahiro  筑波大学, 体育系, 助教 (30726617)

Project Period (FY) 2016-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2017: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2016: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords低強度運動 / 海馬 / ストレス耐性 / うつ病 / RNA-Seq / ストレス抵抗性 / ストレス / 記憶 / うつ行動
Outline of Final Research Achievements

We have already demonstrated that mild exercise increased adult hippocampal neurogenesis and enhanced spatial memory. Recently, it is reported that hippocampus, especially ventral region, is associated to regulate emotion and stress response. It is assumed us that mild exercise reinforces stress resistance through the hippocampus plasticity. The aim in this study is to confirm whether mild exercise enhances stress resistance and to elucidate the mechanism. As a result, we found that mild exercise training for 6 weeks prevented the cognitive decline by acute stress. Then, RNA-Seq analysis had revealed that mice showing stress resistance had notably increased gene expressions in ventral hippocampus compared to dorsal gene expression. These results suggest that mild exercise opens a window of ventral hippocampal plasticity by enhancing gene responsiveness to acute stress. This knowledge would be a clue to prevent the psychiatric disorder related chronic stress such as depression.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • Research Products

    (12 results)

All 2018 2017 2016

All Journal Article (3 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 3 results,  Open Access: 1 results) Presentation (9 results) (of which Int'l Joint Research: 6 results,  Invited: 1 results)

  • [Journal Article] Role of the astroglial glutamate exchanger xCT in ventral hippocampus in resilience to stress.2017

    • Author(s)
      Nasca C, Bigio B, Zelli D, de Angelis P, Lau T, Okamoto M, Soya H, Ni J, Britcha P, Greengard P, Neve RL, Lee F, McEwen BS
    • Journal Title

      Neuron

      Volume: 96 Issue: 2 Pages: 402-413

    • DOI

      10.1016/j.neuron.2017.09.020

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Age and Alzheimer's disease gene expression profiles reversed by the glutamate modulator riluzole2017

    • Author(s)
      Pereira AC, Gray JD, Kogan JF, Davidson RL, Rubin TG, Okamoto M, Morrison JH, McEwen BS
    • Journal Title

      Mol Psychiatry

      Volume: 22 Issue: 2 Pages: 296-305

    • DOI

      10.1038/mp.2016.33

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Moderate exercise ameliorates dysregulated hippocampal glycometabolism and memory function in a rat model of type 2 diabetes.2017

    • Author(s)
      Shima T, Matsui T, Jesmin S, Okamoto M, Soya M, Inoue K, Liu YF, Torres-Aleman I, McEwen BS and Soya H
    • Journal Title

      Diabetologia

      Volume: 60 Issue: 3 Pages: 597-606

    • DOI

      10.1007/s00125-016-4164-4

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] Androgen effect on mild exercise-induced hippocampal neurogenesis2018

    • Author(s)
      Okamoto M
    • Organizer
      Human High Performance-oriented Sports Neuroscience by Integrating Basic Neuroscience
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 軽運動で脳を鍛えることはできるのか?2018

    • Author(s)
      岡本正洋
    • Organizer
      第22回日本体力医学会東海地方会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Brain androgen mediates mild exercise-enhanced adult hippocampal neurogenesis2017

    • Author(s)
      Soya H, Okamoto M, Yook JS
    • Organizer
      The 8th Asia Conference on Kinesiology 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Mild exercise causes dynamic change of hippocampal gene expression in response to acute stress2017

    • Author(s)
      Okamoto M, Pereira, AC, Gray JD, Davidson RL, Kogan JF, Larson CS, McEwen BS, Soya H.
    • Organizer
      Neuroscience 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Glutamatergic modulation rescues behavior in an amyloid mouse model of Alzheimer’s disease.2017

    • Author(s)
      Larson CS, Davidson RL, Okamoto M, McEwen BS, Gray JD, Pereira AC.
    • Organizer
      Neuroscience 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Mild exercise opens a window of ventral hippocampal plasticity by enhancing gene responsiveness to acute stress.2017

    • Author(s)
      Okamoto M, Pereira AC, Gray JD, Davidson RL, Larson CS, Kogan JF, Soya H, McEwen BS.
    • Organizer
      Stress meeting 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 性別を超えて神経を育む脳内アンドロゲン作用:運動による海馬神経新生に着目して.2017

    • Author(s)
      征矢英昭, 岡本正洋
    • Organizer
      第8回テストステロン研究会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Importance of glutamate homeostasis for the beneficial exercise effects on depression and memory2017

    • Author(s)
      Okamoto M
    • Organizer
      Global Initiative for Sports Neuroscience 2017
    • Place of Presentation
      筑波大学(茨城県つくば市)
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] 運動時のストレス応答への視床下部性AVPとCRHの関与:選択的拮抗薬による検討2016

    • Author(s)
      高橋佳那子, 島孟留, 征矢茉莉子, 陸彰洙, 小泉光, 岡本正洋, 征矢英昭
    • Organizer
      第71回日本体力医学大会
    • Place of Presentation
      いわて県民情報交流センター「アイーナ」(岩手県盛岡市)
    • Related Report
      2016 Research-status Report

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Published: 2016-04-21   Modified: 2019-03-29  

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