The effect of exercise to overcome stress and depression: Elucidation of a hippocampal molecular mechanism using RNA-Seq
| Project/Area Number |
16K16559
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Sports science
|
|---|
| Research Institution | University of Tsukuba |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2016-04-01 – 2018-03-31
|
| Project Status |
Completed (Fiscal Year 2017)
|
| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2017: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2016: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
|---|
| Keywords | 低強度運動 / 海馬 / ストレス耐性 / うつ病 / RNA-Seq / ストレス抵抗性 / ストレス / 記憶 / うつ行動 |
|---|
| Outline of Final Research Achievements |
We have already demonstrated that mild exercise increased adult hippocampal neurogenesis and enhanced spatial memory. Recently, it is reported that hippocampus, especially ventral region, is associated to regulate emotion and stress response. It is assumed us that mild exercise reinforces stress resistance through the hippocampus plasticity. The aim in this study is to confirm whether mild exercise enhances stress resistance and to elucidate the mechanism. As a result, we found that mild exercise training for 6 weeks prevented the cognitive decline by acute stress. Then, RNA-Seq analysis had revealed that mice showing stress resistance had notably increased gene expressions in ventral hippocampus compared to dorsal gene expression. These results suggest that mild exercise opens a window of ventral hippocampal plasticity by enhancing gene responsiveness to acute stress. This knowledge would be a clue to prevent the psychiatric disorder related chronic stress such as depression.
|
Report
(3 results)
Research Products
(12 results)
-
[Journal Article] Role of the astroglial glutamate exchanger xCT in ventral hippocampus in resilience to stress.2017
Author(s)
Nasca C, Bigio B, Zelli D, de Angelis P, Lau T, Okamoto M, Soya H, Ni J, Britcha P, Greengard P, Neve RL, Lee F, McEwen BS
-
Journal Title
Neuron
Volume: 96
Issue: 2
Pages: 402-413
DOI
Related Report
Peer Reviewed / Int'l Joint Research
-
-
-
-
-
-
-
-
-
-
-
