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Identification of electrostimulation and blood flow restriction protocols for skeletal muscle hypertrophy

Research Project

Project/Area Number 16K16564
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Sports science
Research InstitutionJuntendo University

Principal Investigator

NATSUME TOSHIHARU  順天堂大学, スポーツ健康科学研究科, 特任助教 (90761841)

Research Collaborator NAITO Hisashi  
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Keywords筋疲労 / パンプアップ / 筋厚 / 筋肥大 / 筋力 / 血流制限 / 電気刺激 / 筋横断面積 / 筋電気刺激
Outline of Final Research Achievements

The purpose of present study was to reveal appropriate neuromuscular electrical stimulation (NMES) and blood flow restriction (BFR) protocols for muscle hypertrophy. We considered these protocols from the point of view of muscle swelling and muscle fatigue immediately after these treatments. According to the results, NMES (frequency, 20Hz; Pulse duration, 500μs; duty cycle, 4 s on: 8 s off) effectively caused muscle swelling and muscle fatigue when combined with 50% of resting arterial occlusion pressure, compared with other conditions. Moreover, the protocol induced muscle hypertrophy after 2 weeks of training than previous NMES with BFR training protocol.

Academic Significance and Societal Importance of the Research Achievements

筋電気刺激と血流制限を組み合わせたトレーニング方法は低体力者でも実施することが可能である。しかしながら効果的に筋肥大や筋力増加を導く至適条件については明らかでない。本研究によって筋力や筋量を増加する至適な実施条件が明らかとなれば疾患や傷害を有する人を対象としたトレーニングの実用化に大きく貢献することができる。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (24 results)

All 2018 2017 2016

All Journal Article (7 results) (of which Peer Reviewed: 4 results) Presentation (17 results) (of which Int'l Joint Research: 11 results)

  • [Journal Article] Electromyostimulation with blood flow restriction enhances activation of mTOR and MAPK signaling pathways in rat gastrocnemius muscles2018

    • Author(s)
      Natsume Toshiharu、Yoshihara Toshinori、Naito Hisashi
    • Journal Title

      Applied Physiology, Nutrition, and Metabolism

      Volume: 6 Issue: 6 Pages: 1-8

    • DOI

      10.1139/apnm-2018-0384

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of training intensity in electromyostimulation on human skeletal muscle2018

    • Author(s)
      Natsume Toshiharu、Ozaki Hayao、Kakigi Ryo、Kobayashi Hiroyuki、Naito Hisashi
    • Journal Title

      European Journal of Applied Physiology

      Volume: 118 Issue: 7 Pages: 1339-1347

    • DOI

      10.1007/s00421-018-3866-3

    • Related Report
      2018 Annual Research Report 2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Neuromuscular electrical stimulation with blood flow restriction increases serum growth hormone concentration2018

    • Author(s)
      Natsume T, Ozaki H, Saito AI, Naito H
    • Journal Title

      Gazzetta medica Italiana

      Volume: 印刷中

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effects of single drop sets resistance training on increase muscle CSA, strength, and endurance: a pilot study2018

    • Author(s)
      Ozaki H, Kubota A, Natsume T, Loenneke JP, Abe T, Machida S, Naito H
    • Journal Title

      Journal of Sports Sciences

      Volume: 36 Issue: 6 Pages: 691-696

    • DOI

      10.1080/02640414.2017.1331042

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Acute changes in blood lactate concentration, muscle thickness and strength after walking with blood flow restriction in older adults2016

    • Author(s)
      Natsume T, Ozaki H, Nakagata T, Machida S, Naito H
    • Journal Title

      Juntendo Medical Journal

      Volume: 62 Pages: 237-242

    • NAID

      130005865669

    • Related Report
      2016 Research-status Report
  • [Journal Article] The effects of the combination of increased physical acyivity with walking with blood flow restriction on leg muscle thickness and walking performance in older adults2016

    • Author(s)
      Ozaki H, Nakagata T, Natsume T, Machida S, Naito H
    • Journal Title

      Juntendo Medical Journal

      Volume: 62 Pages: 206-210

    • Related Report
      2016 Research-status Report
  • [Journal Article] Effect of 6-month walking and stair climbing exercise program and walking with blood flow restriction on body composition and hemoglobin A1c levels in elderly people2016

    • Author(s)
      Yoshihara T, Ozaki H, Nakagata T, Natsume T, Machida S, Naito H
    • Journal Title

      Juntendo Medical Journal

      Volume: 62 Pages: 231-235

    • NAID

      130005865672

    • Related Report
      2016 Research-status Report
  • [Presentation] Electromyostimulation with blood flow restriction enhances activation of mTOR and MAPK signalling pathways in rat gastrocnemius muscles2018

    • Author(s)
      Natsume T, Yoshihara T, Naito H
    • Organizer
      Experimental Biology 2018
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Long-term Physical Inactivity Exacerbates Hindlimb Unloading-induced Soleus Muscle Atrophy In Young Rats2018

    • Author(s)
      Yoshihara T, Tsuzuki T, Chang SW, Natsume T, Kakigi R, Ichinoseki-Sekine N, Machida S, Sugiura T, Naito H
    • Organizer
      ACSM's 65th Annual Meeting
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] 筋電気刺激の刺激強度の違いが筋肥大に及ぼす影響2017

    • Author(s)
      棗寿喜, 尾崎隼朗, 柿木亮, 小林裕幸, 内藤久士
    • Organizer
      第72回日本体力医学会大会
    • Related Report
      2017 Research-status Report
  • [Presentation] 日本と中国における4歳幼児の全身各部位の筋厚と身体活動量に関する研究2017

    • Author(s)
      トウホウウ, 尾崎隼朗, 棗寿喜, 陸大江, 近藤浩晃, 町田修一, 内藤久士
    • Organizer
      第72回日本体力医学会大会
    • Related Report
      2017 Research-status Report
  • [Presentation] 幼児における全身各部位の筋厚および皮脂厚の性差と年齢差2017

    • Author(s)
      尾崎隼朗, トウホウウ, 棗寿喜, 尾崎美那貴, 近藤浩晃, 町田修一, 内藤久士
    • Organizer
      第72回日本体力医学会大会
    • Related Report
      2017 Research-status Report
  • [Presentation] サッカーが高齢者男性における可視骨格筋の形態及び機能に及ぼす影響2017

    • Author(s)
      石原美彦, 尾崎隼朗, 棗寿喜, 石田真大, 井口祐貴, 吉村雅文, 町田修一, 内藤久士
    • Organizer
      第72回日本体力医学会大会
    • Related Report
      2017 Research-status Report
  • [Presentation] Resistance exercise attenuates locomotive syndrome risk in older adults.2016

    • Author(s)
      Natsume T, Ozaki H, Nakagata H, Yoshihara T, Kitada T, Ishihara Y, Ishibashi M, Machida S, Naito H
    • Organizer
      10th International Conference on Strength Training
    • Place of Presentation
      京都アバンティ, 京都府, 京都市
    • Year and Date
      2016-11-30
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Effect of low-load resistance training on muscle and gait function in resistance-untrained elderly individuals2016

    • Author(s)
      Kitada T, Ozaki H, Nakagata T, Yoshihara T, Natsume T, Ishihara Y, Ishibashi M, Machida S, Naito H
    • Organizer
      10th International Conference on Strength Training
    • Place of Presentation
      京都アバンティ, 京都府, 京都市
    • Year and Date
      2016-11-30
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Comparison of the effects of moderate-intensity walking and body mass-based resistance training on lower body muscle size and function in elderly individuals.2016

    • Author(s)
      Ozaki H, Nakagata T, Yoshihara T, Natsume T, Kitada T, Ishihara Y, Ishibashi M, Machida S, Naito H
    • Organizer
      10th International Conference on Strength Training
    • Place of Presentation
      京都アバンティ, 京都府, 京都市
    • Year and Date
      2016-11-30
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] The characteristics of lower body muscle size and functions in elderly people at the early stage of locomotive syndrome2016

    • Author(s)
      Natsume T, Ozaki H, Nakagata H, Yoshihara T, Kitada T, Ishihara Y, Ishibashi M, Machida S, Naito H.
    • Organizer
      2nd Asia Conference for Frailty and Sarcopenia
    • Place of Presentation
      今池ガスビルホール, 愛知県, 名古屋市
    • Year and Date
      2016-11-04
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Effects of 5-month exercise intervention on the locomotive and cognitive function in elderly with locomotive syndrome2016

    • Author(s)
      Ishihara Y, Ozaki H, Nakagata T, Yoshihara T, Natsume T, Kitada T, Ishibashi M, Kuwata H, Miyazaki Y, Ikuta N, Machida S, Naito H
    • Organizer
      2nd Asia Conference for Frailty and Sarcopenia
    • Place of Presentation
      今池ガスビルホール, 愛知県, 名古屋市
    • Year and Date
      2016-11-04
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Lower body muscle size, strength, and quality in elderly Japanese men and women2016

    • Author(s)
      Ozaki H, Nakagata T, Yoshihara T, Natsume T, Kitada T, Ishihara Y, Ishibashi M, Machida S, Naito H
    • Organizer
      2nd Asia Conference for Frailty and Sarcopenia
    • Place of Presentation
      今池ガスビルホール, 愛知県, 名古屋市
    • Year and Date
      2016-11-04
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] 筋電気刺激トレーニング刺激強度の違いが筋肥大及び筋力増加に及ぼす影響2016

    • Author(s)
      棗寿喜, 尾崎隼朗, 柿木亮, 小林裕幸, 内藤久士
    • Organizer
      第71回日本体力医学会大会
    • Place of Presentation
      いわて県民情報交流センター, 岩手県, 盛岡市
    • Year and Date
      2016-09-23
    • Related Report
      2016 Research-status Report
  • [Presentation] Muscle movements combined with blood flow restriction can induce muscle hypertrophy2016

    • Author(s)
      Natsume T, Ozaki H, Watanabe K, Kubota A, Naito H
    • Organizer
      ACSM’s 63rd Annual meeting
    • Place of Presentation
      Boston, USA
    • Year and Date
      2016-05-31
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Dose-dependent effects od whey peptide intake on mTOR signaling in human skeletal muscle2016

    • Author(s)
      Kakigi R, Yoshihata T, Natsume T, Ichinoseki-Sekine N, Kobayashi H, Naito H
    • Organizer
      ACSM’s 63rd Annual meeting
    • Place of Presentation
      Boston, USA
    • Year and Date
      2016-05-31
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Physical inactivity-induced histone modification in the rat soleus muscle2016

    • Author(s)
      Yoshihara T, Kakigi R, Tsuzuki T, Shuo-wen C, Natsume T, Takamine Y, Ichinoseki-Sekine N, Machida S, Sugiura T, Naito H
    • Organizer
      ACSM’s 63rd Annual meeting
    • Place of Presentation
      Boston, USA
    • Year and Date
      2016-05-31
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] 中高齢者サイクリストの最大酸素摂取量と大腿前面筋厚はトレーニング強度に依存する2016

    • Author(s)
      尾崎隼朗,北田友治, 棗寿喜, 町田修一, 内藤久士
    • Organizer
      第71回日本体力医学会大会
    • Place of Presentation
      いわて県民情報交流センター, 岩手県, 盛岡市
    • Related Report
      2016 Research-status Report

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Published: 2016-04-21   Modified: 2020-03-30  

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