| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Outline of Final Research Achievements |
Kinesin is one of motor proteins, which is deeply involved in the important biophenomena including the intracellular transportation of cargo stuffs (organelles and vesicles). In this study, we developed the chemical methods for labeling the kinesin-specific protein-protein interaction to reveal the cargo systems in kinesin. The candidate of the new reactive handle which can change the reactivity based on redox conditions was successfully discovered. We also developed the light-switchable inhibitor to control the kinesin motility. Using this inhibitor, the light controllable kinesin was chemically constructed.
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