| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
We focused on CD1d protein involved in activation of NKT cells, and developed novel potent and selective CD1d glycolipid ligands that can modulate cytokine balance in immune system. The glycolipid derivatives containing various functional groups in their acyl chain parts were designed, synthesized and evaluated to identify a number of selective ligands. The binding mode analysis between the functional groups of lipid ligands and CD1d were also performed by using molecular dynamics simulation.
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