| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
To study the neural mechanisms of top-down behavioral control that involves the use of category information, we applied repetitive transcranial magnetic stimulation (rTMS) to the prefrontal cortex (PFC) before a monkey performed a group-reversal task. The behavioral task had two types of reversals: whole reversal, where the stimulus-outcome contingency changed in all stimuli, and partial reversal, where the contingency changed in only half of the stimuli. In the whole reversal, the monkey could use category information for behavioral adaptation. In the partial reversal, on the other hand, the monkey had to relearn the relations between stimuli and the outcome (juice or saline). We found that the performance in the whole reversal was deteriorated, while that in the partial reversal was not affected, by inactivation of PFC with 1 Hz rTMS. The results suggest that PFC is involved in top-down, but not in bottom-up, behavioral control.
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