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The development of probabilistic-atlas-guided DOT of the infant head

Research Project

Project/Area Number 16K16651
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Basic / Social brain science
Research InstitutionTokyo Metropolitan University (2017-2019)
Yuge National College of Maritime Technology (2016)

Principal Investigator

Tsuzuki Daisuke  首都大学東京, 人文科学研究科, 特任准教授 (50646346)

Project Period (FY) 2016-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2018: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords乳幼児 / 拡散光イメージング / 参照脳 / DOT / 解剖ラベル / 脳機能計測
Outline of Final Research Achievements

We developed a “probabilistic-atlas-guided DOT (pDOT)” approach that uses multiple individual MRI volumes as referential atlases and combines the resulting images to obtain a probabilistic representation. The pDOT based on multiple referential-atlases model can be used without acquisition of a subject-specific structural MRI and circumvent systematic localization biases involved in single-atlas-guided DOT. Thus, this method offers a significant improvement in spatial localization accuracy, approaching that obtained when using a subject-specific anatomy to guide the DOT image reconstruction. Moreover, we developed a pipeline which linearly transforms adult's head to infant's with anatomical labeling via cortical landmarks. This systematic expansion realizes overwrap the sensitivity profiles and reconstructed images in the anatomical information at the gyrus level.

Academic Significance and Societal Importance of the Research Achievements

本研究において提案した確率的 DOT は、複数の脳アトラスを参照して光伝播のシミュレーションならびに脳機能断層像の作成を行う脳機能イメージング法であり、この概念自体に学術的な新規性がある。ならびに、得られた脳機能断層像に脳回レベルの解剖情報を加えてデータを解釈するための基礎的なパイプラインを開発し、精度の高い非侵襲な乳幼児の光脳機能イメージング実現に向けて、嚆矢を放つことができたと考えられる。

Report

(5 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (9 results)

All 2018 2017 2016 Other

All Int'l Joint Research (6 results) Journal Article (1 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (2 results) (of which Int'l Joint Research: 1 results,  Invited: 1 results)

  • [Int'l Joint Research] Boston University(米国)

    • Related Report
      2018 Research-status Report
  • [Int'l Joint Research] University College London(英国)

    • Related Report
      2018 Research-status Report
  • [Int'l Joint Research] Electrical and Computer Engineering Dept/Boston University(米国)

    • Related Report
      2017 Research-status Report
  • [Int'l Joint Research] Department of Physical Therapy/University of Delaware(米国)

    • Related Report
      2017 Research-status Report
  • [Int'l Joint Research] The Optics Division/Martinos Center for Biomedical Imaging(米国)

    • Related Report
      2016 Research-status Report
  • [Int'l Joint Research] Department of Physical Therapy/University of Delaware(米国)

    • Related Report
      2016 Research-status Report
  • [Journal Article] Cortical Activation during Action Observation, Action Execution, and Interpersonal Synchrony in Adults: A functional Near-Infrared Spectroscopy (fNIRS) Study2017

    • Author(s)
      Anjana N. Bhat, Michael D. Hoffman, Susanna L. Trost, McKenzie L. Culotta, Jeffrey Eilbott, Daisuke Tsuzuki and Kevin A. Pelphrey
    • Journal Title

      frontiers in Human Neuroscience

      Volume: 11 Pages: 431-431

    • DOI

      10.3389/fnhum.2017.00431

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] A preliminary report on the probabilistic-atlas-guided DOT2018

    • Author(s)
      Daisuke Tsuzuki, Jay Dubb, Robert J. Cooper, Ippeita Dan, David A. Boas, Meryem A. Yucel
    • Organizer
      fNIRS 2018
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] MRI-Free Spatial Registration and Normalization Techniques for fNIRS2016

    • Author(s)
      Daisuke Tsuzuki
    • Organizer
      CHS Distinguished Lecture Series, University of Delaware
    • Place of Presentation
      STAR Health Sciences Complex, STAR Atrium, 540 S. College Avenue, Newark, DE 19713 (United States)
    • Related Report
      2016 Research-status Report
    • Invited

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Published: 2016-04-21   Modified: 2022-02-21  

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