interpersonal psychotherapy for atypical depression targeting on Regection sensitivity as attachment problems

• Project/Area Number: 16K17339
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Clinical psychology
• Research Institution: Nagoya City University
• Principal Investigator: Risa Imai 名古屋市立大学, 医薬学総合研究院(医学), 助教 (30769336)
• Project Period (FY): 2016-04-01 – 2020-03-31
• Project Status: Completed (Fiscal Year 2019)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2019: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2018: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
• Keywords: 対人関係療法 / 対人過敏 / 併存精神疾患 / 養育体験 / うつ病 / 持続性抑うつ障害 / 治療抵抗性 / 心理療法 / 薬剤抵抗性

Outline of Final Research Achievements

Interpersonal Sensitivity was significantly decreased after the course of interpersonal psychotherapy. In only high interpersonal sensitivity group, interpersonal sensitivity was significantly decreased after intervention. However, the score of interpersonal sensitivity after intervention in high interpersonal sensitivity was higher than the score of overall average before intervention.
Depressive symptom was significantly decreased in chronic depression with psychiatric comorbidities. However, patients with over the three psychiatric comorbidities showed less change of depressive symptoms.

Academic Significance and Societal Importance of the Research Achievements

うつ病患者の一部には薬物療法、心理療法の効果が乏しいため、治療抵抗因子の同定とそれに対する治療法の開発が急務である。対人関係療法は対人過敏性を軽減させる可能性がある一方で、治療前に対人過敏が高い症例は、治療後に軽減しても依然高く、限界があることがわかった。
併存精神疾患をもつ慢性うつ病に対する対人関係療法の研究は少人数のものであるため今後はさらなる研究が必要である。

Research Products

• [Journal Article] Relationships of blood proinflammatory markers with psychological resilience and quality of life in civilian women with posttraumatic stress disorder (2019)
  • Author(s): Imai Risa、Hori Hiroaki、Itoh Mariko、Lin Mingming、Niwa Madoka、Ino Keiko、Ogawa Sei、Sekiguchi Atsushi、Kunugi Hiroshi、Akechi Tatsuo、Kamo Toshiko、Kim Yoshiharu
  • Journal Title: Scientific Reports Volume: 9 Issue: 1 Pages: 17905
  • DOI: 10.1038/s41598-019-54508-0
  • Peer Reviewed / Open Access
• [Journal Article] Memory bias and its association with memory function in women with posttraumatic stress disorder (2019)
  • Author(s): Itoh Mariko、Hori Hiroaki、Lin Mingming、Niwa Madoka、Ino Keiko、Imai Risa、Ogawa Sei、Matsui Mie、Kamo Toshiko、Kim Yoshiharu
  • Journal Title: Journal of Affective Disorders Volume: 245 Pages: 461-467
  • DOI: 10.1016/j.jad.2018.10.365
  • Peer Reviewed
• [Journal Article] Cognitive function in Japanese women with posttraumatic stress disorder: Association with exercise habits (2018)
  • Author(s): Narita-Ohtaki R, Hori H, Itoh M, Lin M, Niwa M, Ino K, Imai R, Ogawa S, Sekiguchi A, Matsui M, Kunugi H, Kamo T, Kim Y
  • Journal Title: Journal of Affective Disorders Volume: 236 Pages: 306
  • DOI: 10.1016/j.jad.2018.02.061
  • Peer Reviewed
• [Journal Article] Inflammatory markers and their possible effects on cognitive function in women with posttraumatic stress disorder (2018)
  • Author(s): Imai R, Hori H, Itoh M, Lin M, Niwa M, Ino K, Ogawa S, Ishida M, Sekiguchi A, Matsui M, Kunugi H, Akechi T, Kamo T, Kim Y
  • Journal Title: Journal of Psychiatric Research Volume: 102 Pages: 192
  • DOI: 10.1016/j.jpsychires.2018.04.009
  • Peer Reviewed
• [Journal Article] Predictors of Broad Dimensions of Psychopathology among Patients with Panic Disorder after Cognitive-Behavioral Therapy (2018)
  • Author(s): Ogawa Sei、Kondo Masaki、Ino Keiko、Imai Risa、Ii Toshitaka、Furukawa Toshi A.、Akechi Tatsuo
  • Journal Title: Psychiatry Journal Volume: 2018 Pages: 1-6
  • DOI: 10.1155/2018/5183834
  • Peer Reviewed / Open Access
• [Presentation] Interpersonal psychotherapy for depressive episode of persistent depressive disorder with psychiatric comorbidity: A case series (2019)
  • Author(s): Risa Imai, Yuko Toshishige, Junya Kuwabara, Masaki Kondo, Takafumi Kinoshita, Tatsuo Akechi, Hiroko Mizushima.
  • Organizer: International Society of Interpersonal Psychotherapy
  • Int'l Joint Research
• [Presentation] 名古屋市立大学精神科における対人関係療法勉強会での取り組み (2018)
  • Author(s): 石黒 由高, 利重 裕子, 桑原 絢也, 今井 理紗, 近藤 真前, 明智 龍男
  • Organizer: 東海精神神経学会
• [Presentation] PTSD女性患者における炎症マーカー：炎症の亢進が認知機能低下に影響を与える可能性 (2018)
  • Author(s): 今井理紗, 堀 弘明, 伊藤真利子, 林 明明, 丹羽まどか, 井野敬子, 小川 成, 石田 牧子, 関口 敦, 松井 三枝, 功刀 浩, 明智龍男, 加茂登志子, 金 吉晴
  • Organizer: 日本生物学的精神医学会
• [Presentation] 抑うつエピソード中の入院患者に測定した5因子性格特性・対人過敏性におけるうつ病患者と双極性障害患者との比較 (2018)
  • Author(s): 今井理紗, 近藤真前, 井野敬子, 小川成, 赤毛太郎, 木下貴文, 松永由美子, 石黒由高, 小澤大嗣, 橋本伸彦, 高畠聡, 桑原絢也, 利重裕子, 明智龍男
  • Organizer: 日本うつ病学会