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Neural mechanisms of action selection based on left-right orientation

Research Project

Project/Area Number 16K17369
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Experimental psychology
Research InstitutionTokyo Metropolitan Institute of Medical Science

Principal Investigator

NAKAYAMA Yoshihisa  公益財団法人東京都医学総合研究所, 認知症・高次脳機能研究分野, 主席研究員 (30585906)

Project Period (FY) 2016-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords一次運動野 / 両手運動 / 単一ニューロン / 局所フィールド電位 / ニホンザル / 運動前野 / 左右認識 / 機能的MRI / 大脳基底核
Outline of Final Research Achievements

Activity of neurons and local field potentials (LFPs) was recorded from the primary motor cortex (M1) and higher-order motor areas while macaque monkeys were performing a button-press task with either the right or left hand. Neuronal activity of the M1 reflected contralateral hand movements more often than ipsilateral ones. In addition, neuronal activities in the M1 were correlated with reaction times of contralateral hand movements more strongly than those in higher-order motor areas. Moreover, high-gamma and theta bands of LFPs represented contralateral hand movements. These findings suggest that while higher-order motor areas play a role in selecting which hand to use, the M1 plays a crucial role in initiating contralateral hand movements.

Academic Significance and Societal Importance of the Research Achievements

左右の身体表現の脳内表現を調べるため、左右の手を使い分ける動作を遂行中のサルより、一次運動野および高次運動野の神経活動を記録した。高次運動野が左右の手の選択に関わるのに対し、一次運動野は選択された手が反対側の場合にのみ、その動作の開始に関与することが明らかとなった。左右の手の使い分けという基本的な動作について、その機能を実現するために手を選択し準備・実行する一連の過程に関して、高次運動野から一次運動野にかけて階層的な処理がなされていることを示唆する。

Report

(5 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (18 results)

All 2020 2019 2018 2017 2016 Other

All Journal Article (5 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 3 results,  Open Access: 2 results) Presentation (12 results) (of which Int'l Joint Research: 5 results) Remarks (1 results)

  • [Journal Article] Cerebellar outputs contribute to spontaneous and movement-related activity in the motor cortex of monkeys2020

    • Author(s)
      Sano Nobuya、Nakayama Yoshihisa、Ishida Hiroaki、Chiken Satomi、Hoshi Eiji、Nambu Atsushi、Nishimura Yukio
    • Journal Title

      Neuroscience Research

      Volume: - Pages: 10-21

    • DOI

      10.1016/j.neures.2020.03.010

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 精神状態と運動パフォーマンス2018

    • Author(s)
      鈴木迪諒・中山 義久・西村 幸男
    • Journal Title

      Clinical Neuroscience

      Volume: 36 Pages: 1216-1218

    • Related Report
      2018 Research-status Report
  • [Journal Article] 増大特集 ブロードマン領野の現在地 動作制御機能の中枢2017

    • Author(s)
      中山義久・星 英司
    • Journal Title

      BRAIN and NERVE

      Volume: 69 Issue: 4 Pages: 327-337

    • DOI

      10.11477/mf.1416200749

    • ISSN
      1344-8129, 1881-6096
    • Year and Date
      2017-04-01
    • Related Report
      2017 Research-status Report
  • [Journal Article] Visuomotor signals for reaching movements in the rostro-dorsal sector of the monkey thalamic reticular nucleus.2017

    • Author(s)
      Saga Y, Nakayama Y, Inoue K, Yamagata T, Hashimoto M, Tremblay L, Takada M, Hoshi E
    • Journal Title

      Eur J Neurosci

      Volume: 印刷中 Issue: 9 Pages: 1186-1199

    • DOI

      10.1111/ejn.13421

    • NAID

      120006305932

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Rostrocaudal functional gradient among the pre-dorsal premotor cortex, dorsal premotor cortex, and primary motor cortex in goal-directed motor behavior2016

    • Author(s)
      Yoshihisa NAKAYAMA, Tomoko YAMAGATA, and Eiji HOSHI
    • Journal Title

      European Journal of Neuroscience

      Volume: - Issue: 12 Pages: 1569-1589

    • DOI

      10.1111/ejn.13254

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Presentation] Representations of hand movements by neurons and local field potentials in the primary motor cortex and medial motor areas in monkeys2019

    • Author(s)
      Yoshihisa NAKAYAMA, Osamu YOKOYAMA, and Eiji HOSHI
    • Organizer
      日本神経科学学会第42回大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Encoding of contralateral and ipsilateral hand movements by neurons and local field potentials in the primary motor cortex in monkeys.2018

    • Author(s)
      Yoshihisa NAKAYAMA, Osamu YOKOYAMA, and Eiji HOSHI
    • Organizer
      48th annual meeting of the Society for Neuroscience
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Cerebellar outputs contribute to the activity of the primary motor cortex during arm-reaching movement in macaque monkeys.2018

    • Author(s)
      Nobuya SANO, Yoshihisa NAKAYAMA, Eiji HOSHI, Satomi CHIKEN, Atsushi NAMBU, and Yukio NISHIMURA
    • Organizer
      48th annual meeting of the Society for Neuroscience
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Cerebellar outputs modulate neuronal activity in the primary motor cortex during movement execution in macaque monkeys.2018

    • Author(s)
      Nobuya SANO, Yoshihisa NAKAYAMA, Eiji HOSHI, Satomi CHIKEN, Atsushi NAMBU, and Yukio NISHIMURA
    • Organizer
      日本神経科学学会第41回大会
    • Related Report
      2018 Research-status Report
  • [Presentation] Area-specific involvement of frontal areas and the basal ganglia in goal-directed behavior in monkeys.2017

    • Author(s)
      Yoshihisa NAKAYAMA, Tomoko YAMAGATA, Nariko ARIMURA, and Eiji HOSHI
    • Organizer
      37th annual meeting of the Society for Neuroscience
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] 行動ゴール達成過程における複数脳領域の関与の比較2017

    • Author(s)
      中山義久・山形朋子・有村奈利子・星 英司
    • Organizer
      日本心理学会第81回大会
    • Related Report
      2017 Research-status Report
  • [Presentation] Motor commands transferred from the deep cerebellar nuclei to the motor cortex.2017

    • Author(s)
      Nobuya SANO, Yoshihisa NAKAYAMA, Eiji HOSHI, Satomi CHIKEN, Atsushi NAMBU, and Yukio NISHIMURA
    • Organizer
      日本神経科学学会第40回大会
    • Related Report
      2017 Research-status Report
  • [Presentation] Fronto-basal ganglia network involved in the process of achieving behavioral goal.2017

    • Author(s)
      Yoshihisa NAKAYAMA, Tomoko YAMAGATA, Nariko ARIMURA, and Eiji HOSHI
    • Organizer
      日本神経科学学会第40回大会
    • Related Report
      2017 Research-status Report
  • [Presentation] Neurons in the globus pallidus, supplementary motor area, and caudal cingulate motor area are differentially involved in contralateral and ipsilateral hand movements in monkeys.2016

    • Author(s)
      Yoshihisa NAKAYAMA, Osamu YOKOYAMA, and Eiji HOSHI
    • Organizer
      46th annual meeting of the Society for Neuroscience
    • Place of Presentation
      San Diego Convention Center(米国・サンディエゴ)
    • Year and Date
      2016-11-12
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Encoding of contralateral and ipsilateral hand movements by high-gamma and theta bands of local field potentials in the globus pallidus of monkeys.2016

    • Author(s)
      Osamu YOKOYAMA, Yoshihisa NAKAYAMA, and Eiji HOSHI
    • Organizer
      46th annual meeting of the Society for Neuroscience
    • Place of Presentation
      San Diego Convention Center(米国・サンディエゴ)
    • Year and Date
      2016-11-12
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Role of the globus pallidus of monkeys in ipsilateral and contralateral hand movements.2016

    • Author(s)
      Yoshihisa NAKAYAMA, Osamu YOKOYAMA, and Eiji HOSHI
    • Organizer
      日本神経科学学会第39回大会
    • Place of Presentation
      パシフィコ横浜(神奈川県・横浜市)
    • Year and Date
      2016-07-20
    • Related Report
      2016 Research-status Report
  • [Presentation] Response properties of primary motor cortical neurons influenced by the deep cerebellar nuclei stimulation.2016

    • Author(s)
      Nobuya SANO, Yoshihisa NAKAYAMA, Satomi CHIKEN, Atsushi NAMBU, and Eiji HOSHI
    • Organizer
      日本神経科学学会第39回大会
    • Place of Presentation
      パシフィコ横浜(神奈川県・横浜市)
    • Year and Date
      2016-07-20
    • Related Report
      2016 Research-status Report
  • [Remarks] 公益財団法人 東京都医学総合研究所 脳機能再建プロジェクト

    • URL

      http://www.igakuken.or.jp/project/to-tomin/to-pro09.html

    • Related Report
      2019 Annual Research Report 2018 Research-status Report 2017 Research-status Report

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Published: 2016-04-21   Modified: 2021-02-19  

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