Improvement of Early Screening Accuracy in High-Functioning Autism Spectrum Disorder

• Project/Area Number: 16K17464
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Special needs education
• Research Institution: Hirosaki University
• Principal Investigator: Adachi Masaki 弘前大学, 医学研究科, 特任講師 (50637329)
• Research Collaborator: TAKAHASHI michio ; YASUDA sayura ; TAKAYANAGI nobuya ; SAITO manabu ; HIROTA tomoya ; OSATO ayako ; MIKAMI misaki ; SAKAMOTO yui ; TANAKA masanori ; Masuda takahito ; KURIBAYASHI michito ; KATO sumi ; NAKAMURA kazuhiko
• Project Period (FY): 2016-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000); Fiscal Year 2018: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
• Keywords: 自閉スペクトラム症 / 早期発見 / スクリーニング / 質問紙 / 発達障害 / ASSQ / カットオフ / ASD / 自閉症 / Autism / AUC / 感度 / 特異度 / 保護者評定 / 教師評定 / 早期発見・早期支援 / 高機能

Outline of Final Research Achievements

In this project, we examined the applicability of the ASSQ in preschool children. We examined the short version, which has been verified in Japan for psychological measurement accuracy, and the full scale, which is used internationally.
In the short version, 1,919 children, including 59 children diagnosed with ASD, were examined to verify the measurement accuracy of the ASSQ. As a result of ROC analysis, AUC was 0.92 for boys and 0.91 for girls, showing excellent discrimination accuracy. From the viewpoint of sensitivity and specificity, the cut-off in the community were proposed 3 points for boys and 4 points for girls.
In the full version, we tested parent-rating ASSQ for preschool children in clinical (N = 154) and community settings (N = 1,390). The results showed, the ASSQ had reliability and validity as a screening instrument for preschool children. A cut-off of 7 with sensitivity of 0.93 and specificity of 0.84 is recommended for community screening.

Academic Significance and Societal Importance of the Research Achievements

これまでAutism Spectrum Screening Questionnaire (ASSQ)の就学前児に対する測定精度は国際的にも検討されてこなかったため、結果が国際誌にアクセプトされたことは、学術的意義が大きいものと考えられる。また、国内においても、本課題において尺度の識別精度やコミュニティで使用できるカットオフ値が明らかにされたことによって、高機能自閉スペクトラム児の早期スクリーニングが促進されることが期待できる。結果として、これまで支援への接続の遅れが指摘されてきた高機能自閉症児を、より早い段階で支援に繋げられる可能性を期待でき、この社会的意義は大きいものと考えられる。

Research Products

• [Int'l Joint Research] カリフォルニア大学サンフランシスコ校 (UCSF)(米国)
• [Journal Article] Adaptation of the Autism Spectrum Screening Questionnaire (ASSQ) to preschool children (2018)
  • Author(s): Adachi Masaki、Takahashi Michio、Takayanagi Nobuya、Yoshida Satomi、Yasuda Sayura、Tanaka Masanori、Osato-Kaneda Ayako、Saito Manabu、Kuribayashi Michito、Kato Sumi、Nakamura Kazuhiko
  • Journal Title: PLOS ONE Volume: 13 Issue: 7 Pages: 1-19
  • DOI: 10.1371/journal.pone.0199590
  • Peer Reviewed / Open Access
• [Journal Article] Prevalence of pathological and maladaptive Internet use and the association with depression and health-related quality of life in Japanese elementary and junior high school-aged children (2018)
  • Author(s): Takahashi Michio、Adachi Masaki、Nishimura Tomoko、Hirota Tomoya、Yasuda Sayura、Kuribayashi Michito、Nakamura Kazuhiko
  • Journal Title: Social Psychiatry and Psychiatric Epidemiology Volume: 53 Issue: 12 Pages: 1349-1359
  • DOI: 10.1007/s00127-018-1605-z
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Differences in sleep problems between Japanese and Chinese preschoolers: a cross-cultural comparison within the Asian region (2018)
  • Author(s): Takahashi Michio、Wang Guanghai、Adachi Masaki、Jiang Fan、Jiang Yanrui、Saito Manabu、Nakamura Kazuhiko
  • Journal Title: Sleep medicine Volume: 印刷中 Pages: 42-48
  • DOI: 10.1016/j.sleep.2017.11.1145
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] The prevalence of sleep problems among Japanese preschoolers in a medium-sized city: A community-based survey using the Children’s Sleep Habits Questionnaire (2017)
  • Author(s): Takahashi M, Adachi M, Yasuda S, Osato-Kaneda A, Saito M, Kuribayashi M, Nakamura K., Article accepted on 14 March, 2017,
  • Journal Title: Pediatrics International (in press) Volume: 印刷中 Issue: 6 Pages: 747-750
  • DOI: 10.1111/ped.13281
  • Peer Reviewed / Open Access
• [Journal Article] ASSQ短縮版の5歳児適用における妥当性 (2016)
  • Author(s): 足立 匡基, 高柳 伸哉, 吉田 恵心, 安田 小響, 大里 絢子, 田中 勝則, 増田 貴人, 栗林 理人, 斉藤 まなぶ, 中村 和彦
  • Journal Title: 児童青年精神医学とその近接領域 Volume: 57 Pages: 603-617
  • NAID: 130006865848
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Psychometric properties of the Japanese ADHD-RS in preschool children. (2016)
  • Author(s): Takayanagi N, Yoshida S, Yasuda S, Adachi M, Kaneda-Osato A, Tanaka M, Masuda T, Kuribayashi M, Saito M, Nakamura K.
  • Journal Title: Res Dev Disabil. Volume: 55 Pages: 268-78
  • DOI: 10.1016/j.ridd.2016.05.002
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] 5歳児発達健診における発達障害の疫学 (2016)
  • Author(s): 斉藤 まなぶ, 吉田 恵心, 坂本 由唯, 大里 絢子, 足立 匡基, 安田 小響, 栗林 理人, 中村 和彦
  • Journal Title: 日本生物学的精神医学会誌 Volume: 27 Pages: 60-64
  • NAID: 130006338396
  • Peer Reviewed
• [Journal Article] 発達支援のアセスメント 自閉症スペクトラム障害の早期発見 (2016)
  • Author(s): 斉藤まなぶ, 吉田恵心, 高柳伸哉, 安田小響, 足立匡基, 大里絢子, 中村和彦
  • Journal Title: 臨床心理学 Volume: 16 Pages: 145-150
  • Peer Reviewed
• [Journal Article] 5歳児健診の現状と課題 (2016)
  • Author(s): 斉藤まなぶ, 吉田 恵心, 髙柳 伸哉, 安田 小響, 足立 匡基, 大里 絢子, 中村 和彦
  • Journal Title: 児童青年精神医学とその近接領域 Volume: 57 Pages: 254-260
  • NAID: 130007691875
  • Peer Reviewed
• [Presentation] Discriminant Validity of the Autism Spectrum Screening Questionnaire Parent Form to Preschool Children (2018)
  • Author(s): Adachi M, Takashi M, Takayanagi N, Yasuda S, Sakamoto Y, Tanaka M, Osato A, Kato S, Nakamura K.
  • Organizer: International Society for Autism Research 2018 Annual Meeting
  • Int'l Joint Research
• [Presentation] Decreased Satisfaction in Peer Relationships Is Strongly Associated with Depression in Children with High ASD Traits: A Population-Based Cross-Sectional Study in Japan. (2018)
  • Author(s): Takahashi M, Adachi M, Yasuda S, Nakamura K.
  • Organizer: International Society for Autism Research 2018 Annual Meeting
  • Int'l Joint Research
• [Presentation] Gender Difference of Gaze Fixation Patterns in 5-Year -Old Children -the Usefulness of Early Detection of Girls with Autism (2018)
  • Author(s): Sakamoto Y, Saito M, Tsuchiya K. J, Osato A, Kato S, Matsubara Y, Mikami T, Adachi M, Takahashi M, Yasuda S, Nakamura K.
  • Organizer: International Society for Autism Research 2018 Annual Meeting
  • Int'l Joint Research
• [Presentation] 新しい子どもの発達アセスメントツール (2018)
  • Author(s): 安田小響・足立匡基・萩原拓・村山恭朗・浜田恵・髙橋芳雄
  • Organizer: 第37回日本心理臨床学会
• [Presentation] 幼児期におけるAutism Spectrum Screening Questionnaire(ASSQ)の測定精度の検証 (2017)
  • Author(s): 足立匡基・高栁伸哉・吉田恵心・安田小響・髙橋芳雄・大里絢子・田中勝則・増田貴人・坂本由唯・三上美咲・栗林理人・斉藤まなぶ・中村和彦
  • Organizer: 日本児童青年精神医学会第58回総会
  • Invited
• [Presentation] Behavioral problems in preschool children with Developmental Coordination Disorder. (2017)
  • Author(s): Adachi M, Takayanagi N, Takahashi M, Yasuda S, Yoshida S, Mikami M, Nakai A, Saito M, Nakamura K.
  • Organizer: DCD12(International Conference for Developmental Coordination Disorder)
  • Int'l Joint Research
• [Presentation] Developmental Coordination Disorder trait in Japanese preschoolers impact on parenting stress. (2017)
  • Author(s): Takahashi M, Adachi M, Takayanagi N, Yasuda S, Osato-Kaneda A, Mikami M, Nakai A, Saito M, Kuribayashi M, Nakamura K.
  • Organizer: DCD12(International Conference for Developmental Coordination Disorder)
  • Int'l Joint Research
• [Presentation] Evaluation of factor structure equivalence of the Developmental Coordination Disorder Questionnaire across genders in Japanese preschool children: HFC study. (2017)
  • Author(s): Tanaka M, Saito M, Kaneda-Osato A, Masuda T, Takayanagi N, Takahashi M, Adachi M, Yasuda S, Yoshida S, Kuribayashi, M, Nakai A, Miyahara M, Nakamura K, Sakamoto Y.
  • Organizer: DCD12(International Conference for Developmental Coordination Disorder)
  • Int'l Joint Research
• [Presentation] Prevalence and comorbidities of DCD Using DSM-5, comparison of motor and cognitive functions at preschool age in a Japanese community. (2017)
  • Author(s): Saito M, Osato-Kaneda A, Tanaka M, Masuda T, Yoshida S, Sakamoto Y, Matsubara Y, Takayanagi N, Adachi, M, Takahashi M, Yasuda S, Kuribayashi M, Nakai A, Miyahara M, Nakamura K.
  • Organizer: DCD12(International Conference for Developmental Coordination Disorder)
  • Int'l Joint Research
• [Presentation] The parental and tescher’s recognition for Developmental Coordination Disorder in preschool-aged children. (2017)
  • Author(s): Mikami M, Saito M, Masuda T, Tanaka M, Osato A, Sakamoto Y, Yoshida S, Takayanagi N, Adachi M, Yasuda S, Kuribayashi M, Nakamura K.
  • Organizer: DCD12(International Conference for Developmental Coordination Disorder)
  • Int'l Joint Research
• [Presentation] Gaze Abnormality Can Distinguish Between Autism Spectrum Disorder and Typically Developing Children through Screening in 5-Year-Old Children By a Double Blind Study in a Japanese Community Based Population. (2017)
  • Author(s): Saito M, Adachi M, Yoshida S, Yasuda S, Kuribayashi M, Sakamoto Y, Nakamura K, Takayanagi N.
  • Organizer: IMFAR(International Meeting for Autism Research)
  • Int'l Joint Research
• [Presentation] Prevalence and Comorbidities of Autism Spectrum Disorder and Study of the Developmental Health Checkup in a Japanese Community-Based Population Sample of Five-Year-Old Children. (2017)
  • Author(s): Sakamoto Y, Saito M, Yoshida S, Adachi M, Takayanagi N, Yasuda S, Kuribayashi M, Nakamura K.
  • Organizer: IMFAR(International Meeting for Autism Research)
  • Int'l Joint Research
• [Presentation] 地域根差した子どもに包括的な発達支援と臨床心理士の役割 (2017)
  • Author(s): 足立匡基・高橋芳雄・安田小響・浜田恵・村山恭朗
  • Organizer: 日本心理臨床学会第36回大会
• [Presentation] スクリーニングツルに基づく児童思春期おけるASD 有病率の推計およびASD傾向と適応状態の関連 (2016)
  • Author(s): 足立匡基, 高栁伸哉, 安田小響, 吉田恵心, 栗林理人, 大里絢子, 斉藤まなぶ, 中村和彦.
  • Organizer: 第57回日本児童青年精神医学会総会
  • Place of Presentation: 岡山コンベンションセンター(岡山県・岡山市)
  • Year and Date: 2016-10-27
• [Presentation] 短縮版感覚プロファイルを用いた子どもの感覚の特異性の関連 (2016)
  • Author(s): 安田小響, 足立匡基, 斉藤まなぶ, 大里絢子, 吉田恵心, 栗林理人, 増田貴人, 髙栁伸哉, 田中勝則, 中村和彦
  • Organizer: 第57回日本児童青年精神医学会総会
  • Place of Presentation: 岡山コンベンションセンター(岡山県・岡山市)
  • Year and Date: 2016-10-27
• [Presentation] GazeFinde(Kao-TV)を用いた5歳児のASD特性の検討 (2016)
  • Author(s): 斉藤まなぶ, 坂本由唯, 大里絢子, 吉田恵心, 髙栁伸哉, 足立匡基, 安田小響, 田中勝則, 増田貴人, 栗林理人, 中村和彦
  • Organizer: 第57回日本児童青年精神医学会総会
  • Place of Presentation: 岡山コンベンションセンター(岡山県・岡山市)
  • Year and Date: 2016-10-27
• [Presentation] 某市5歳児発達健診から見た運動機能と認知機能関係 (2016)
  • Author(s): 大里絢子, 斉藤まなぶ, 坂本由唯, 吉田恵心, 髙栁伸哉, 足立匡基, 安田小響, 田中勝則, 増田貴人, 栗林理人
  • Organizer: 第57回日本児童青年精神医学会総会
  • Place of Presentation: 岡山コンベンションセンター(岡山県・岡山市)
  • Year and Date: 2016-10-27
• [Presentation] 発達性協調運動障害への保護者・先生の気づきに関する検討. 第57回日本児童青年精神医学会総会 (2016)
  • Author(s): 三上美咲, 斉藤まなぶ, 増田貴人, 田中勝則, 大里絢子, 坂本由唯, 吉田恵心, 髙栁伸哉, 足立匡基, 安田小響, 栗林理人, 中村和彦
  • Organizer: 第57回日本児童青年精神医学会総会
  • Place of Presentation: 岡山コンベンションセンター(岡山県・岡山市)
  • Year and Date: 2016-10-27
• [Presentation] 5歳児の自閉スペクトラム障害におけるVLDL、IGF-1、オキシトシンの診断有用性の検討 (2016)
  • Author(s): 斉藤まなぶ, 下山修司, 吉田恵心, 坂本由唯, 大里絢子, 高柳伸哉, 足立匡基, 安田小響, 栗林理人, 中村和彦
  • Organizer: 第112回日本精神神経学会学術総会
  • Place of Presentation: 幕張メッセ(千葉県・千葉市)
  • Year and Date: 2016-06-02
• [Presentation] Applicability of the Autism Spectrum Screening Questionnaire Parent Form to 5-Year-Old Children. (2016)
  • Author(s): Adachi M, Takayanagi N, Yasuda S, Yoshida S, Kuribayashi M, Osato A, Masuda T, Tanaka M, Saito M, Nakamura K.
  • Organizer: International Society for Autism Research
  • Place of Presentation: Baltimore(アメリカ合衆国)
  • Year and Date: 2016-05-11
  • Int'l Joint Research
• [Presentation] Prevalence of Autism Spectrum Disorder in a Japanese Community-Based Population Sample of Five-Year-Old Children. (2016)
  • Author(s): Saito M, Takayanagi N, Adachi M, Osato A, Yasuda, S, Masuda, M. Tanaka, S. Yoshida, M. Kuribayashi M, Nakamura K.
  • Organizer: International Society for Autism Research
  • Place of Presentation: Baltimore(アメリカ合衆国)
  • Year and Date: 2016-05-11
  • Int'l Joint Research
• [Presentation] Risk and Protective Factors of Depression in Children with ASD Tendency in Japan. (2016)
  • Author(s): Takayanagi N, Adachi A, Yasuda S, Yoshida S, Kuribayashi M, Nakamura.
  • Organizer: International Society for Autism Research
  • Place of Presentation: Baltimore(アメリカ合衆国)
  • Year and Date: 2016-05-11
  • Int'l Joint Research
• [Remarks] Researchmap
  • URL: https://researchmap.jp/-------/
• [Remarks] Researchgate
  • URL: https://www.researchgate.net/profile/Masaki_Adachi2
• [Remarks] 弘前大学大学院医学研究科附属子どものこころの発達研究センター
  • URL: http://www.med.hirosaki-u.ac.jp/~kodomono/
• [Remarks] researchmap
  • URL: https://researchmap.jp/-------
• [Remarks] researchmap
  • URL: http://researchmap.jp/-------/