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Improvement of Early Screening Accuracy in High-Functioning Autism Spectrum Disorder

Research Project

Project/Area Number 16K17464
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Special needs education
Research InstitutionHirosaki University

Principal Investigator

Adachi Masaki  弘前大学, 医学研究科, 特任講師 (50637329)

Research Collaborator TAKAHASHI michio  
YASUDA sayura  
TAKAYANAGI nobuya  
SAITO manabu  
HIROTA tomoya  
OSATO ayako  
MIKAMI misaki  
SAKAMOTO yui  
TANAKA masanori  
Masuda takahito  
KURIBAYASHI michito  
KATO sumi  
NAKAMURA kazuhiko  
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2018: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Keywords自閉スペクトラム症 / 早期発見 / スクリーニング / 質問紙 / 発達障害 / ASSQ / カットオフ / ASD / 自閉症 / Autism / AUC / 感度 / 特異度 / 保護者評定 / 教師評定 / 早期発見・早期支援 / 高機能
Outline of Final Research Achievements

In this project, we examined the applicability of the ASSQ in preschool children. We examined the short version, which has been verified in Japan for psychological measurement accuracy, and the full scale, which is used internationally.
In the short version, 1,919 children, including 59 children diagnosed with ASD, were examined to verify the measurement accuracy of the ASSQ. As a result of ROC analysis, AUC was 0.92 for boys and 0.91 for girls, showing excellent discrimination accuracy. From the viewpoint of sensitivity and specificity, the cut-off in the community were proposed 3 points for boys and 4 points for girls.
In the full version, we tested parent-rating ASSQ for preschool children in clinical (N = 154) and community settings (N = 1,390). The results showed, the ASSQ had reliability and validity as a screening instrument for preschool children. A cut-off of 7 with sensitivity of 0.93 and specificity of 0.84 is recommended for community screening.

Academic Significance and Societal Importance of the Research Achievements

これまでAutism Spectrum Screening Questionnaire (ASSQ)の就学前児に対する測定精度は国際的にも検討されてこなかったため、結果が国際誌にアクセプトされたことは、学術的意義が大きいものと考えられる。また、国内においても、本課題において尺度の識別精度やコミュニティで使用できるカットオフ値が明らかにされたことによって、高機能自閉スペクトラム児の早期スクリーニングが促進されることが期待できる。結果として、これまで支援への接続の遅れが指摘されてきた高機能自閉症児を、より早い段階で支援に繋げられる可能性を期待でき、この社会的意義は大きいものと考えられる。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (37 results)

All 2018 2017 2016 Other

All Int'l Joint Research (1 results) Journal Article (9 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 9 results,  Open Access: 5 results,  Acknowledgement Compliant: 1 results) Presentation (22 results) (of which Int'l Joint Research: 13 results,  Invited: 1 results) Remarks (5 results)

  • [Int'l Joint Research] カリフォルニア大学サンフランシスコ校 (UCSF)(米国)

    • Related Report
      2018 Annual Research Report
  • [Journal Article] Adaptation of the Autism Spectrum Screening Questionnaire (ASSQ) to preschool children2018

    • Author(s)
      Adachi Masaki、Takahashi Michio、Takayanagi Nobuya、Yoshida Satomi、Yasuda Sayura、Tanaka Masanori、Osato-Kaneda Ayako、Saito Manabu、Kuribayashi Michito、Kato Sumi、Nakamura Kazuhiko
    • Journal Title

      PLOS ONE

      Volume: 13 Issue: 7 Pages: 1-19

    • DOI

      10.1371/journal.pone.0199590

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Prevalence of pathological and maladaptive Internet use and the association with depression and health-related quality of life in Japanese elementary and junior high school-aged children2018

    • Author(s)
      Takahashi Michio、Adachi Masaki、Nishimura Tomoko、Hirota Tomoya、Yasuda Sayura、Kuribayashi Michito、Nakamura Kazuhiko
    • Journal Title

      Social Psychiatry and Psychiatric Epidemiology

      Volume: 53 Issue: 12 Pages: 1349-1359

    • DOI

      10.1007/s00127-018-1605-z

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Differences in sleep problems between Japanese and Chinese preschoolers: a cross-cultural comparison within the Asian region2018

    • Author(s)
      Takahashi Michio、Wang Guanghai、Adachi Masaki、Jiang Fan、Jiang Yanrui、Saito Manabu、Nakamura Kazuhiko
    • Journal Title

      Sleep medicine

      Volume: 印刷中 Pages: 42-48

    • DOI

      10.1016/j.sleep.2017.11.1145

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The prevalence of sleep problems among Japanese preschoolers in a medium-sized city: A community-based survey using the Children’s Sleep Habits Questionnaire2017

    • Author(s)
      Takahashi M, Adachi M, Yasuda S, Osato-Kaneda A, Saito M, Kuribayashi M, Nakamura K., Article accepted on 14 March, 2017,
    • Journal Title

      Pediatrics International (in press)

      Volume: 印刷中 Issue: 6 Pages: 747-750

    • DOI

      10.1111/ped.13281

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] ASSQ短縮版の5歳児適用における妥当性2016

    • Author(s)
      足立 匡基, 高柳 伸哉, 吉田 恵心, 安田 小響, 大里 絢子, 田中 勝則, 増田 貴人, 栗林 理人, 斉藤 まなぶ, 中村 和彦
    • Journal Title

      児童青年精神医学とその近接領域

      Volume: 57 Pages: 603-617

    • NAID

      130006865848

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Psychometric properties of the Japanese ADHD-RS in preschool children.2016

    • Author(s)
      Takayanagi N, Yoshida S, Yasuda S, Adachi M, Kaneda-Osato A, Tanaka M, Masuda T, Kuribayashi M, Saito M, Nakamura K.
    • Journal Title

      Res Dev Disabil.

      Volume: 55 Pages: 268-78

    • DOI

      10.1016/j.ridd.2016.05.002

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 5歳児発達健診における発達障害の疫学2016

    • Author(s)
      斉藤 まなぶ, 吉田 恵心, 坂本 由唯, 大里 絢子, 足立 匡基, 安田 小響, 栗林 理人, 中村 和彦
    • Journal Title

      日本生物学的精神医学会誌

      Volume: 27 Pages: 60-64

    • NAID

      130006338396

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] 発達支援のアセスメント 自閉症スペクトラム障害の早期発見2016

    • Author(s)
      斉藤まなぶ, 吉田恵心, 高柳伸哉, 安田小響, 足立匡基, 大里絢子, 中村和彦
    • Journal Title

      臨床心理学

      Volume: 16 Pages: 145-150

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] 5歳児健診の現状と課題2016

    • Author(s)
      斉藤まなぶ, 吉田 恵心, 髙柳 伸哉, 安田 小響, 足立 匡基, 大里 絢子, 中村 和彦
    • Journal Title

      児童青年精神医学とその近接領域

      Volume: 57 Pages: 254-260

    • NAID

      130007691875

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Presentation] Discriminant Validity of the Autism Spectrum Screening Questionnaire Parent Form to Preschool Children2018

    • Author(s)
      Adachi M, Takashi M, Takayanagi N, Yasuda S, Sakamoto Y, Tanaka M, Osato A, Kato S, Nakamura K.
    • Organizer
      International Society for Autism Research 2018 Annual Meeting
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Decreased Satisfaction in Peer Relationships Is Strongly Associated with Depression in Children with High ASD Traits: A Population-Based Cross-Sectional Study in Japan.2018

    • Author(s)
      Takahashi M, Adachi M, Yasuda S, Nakamura K.
    • Organizer
      International Society for Autism Research 2018 Annual Meeting
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Gender Difference of Gaze Fixation Patterns in 5-Year -Old Children -the Usefulness of Early Detection of Girls with Autism2018

    • Author(s)
      Sakamoto Y, Saito M, Tsuchiya K. J, Osato A, Kato S, Matsubara Y, Mikami T, Adachi M, Takahashi M, Yasuda S, Nakamura K.
    • Organizer
      International Society for Autism Research 2018 Annual Meeting
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 新しい子どもの発達アセスメントツール2018

    • Author(s)
      安田小響・足立匡基・萩原拓・村山恭朗・浜田恵・髙橋芳雄
    • Organizer
      第37回日本心理臨床学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 幼児期におけるAutism Spectrum Screening Questionnaire(ASSQ)の測定精度の検証2017

    • Author(s)
      足立匡基・高栁伸哉・吉田恵心・安田小響・髙橋芳雄・大里絢子・田中勝則・増田貴人・坂本由唯・三上美咲・栗林理人・斉藤まなぶ・中村和彦
    • Organizer
      日本児童青年精神医学会第58回総会
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] Behavioral problems in preschool children with Developmental Coordination Disorder.2017

    • Author(s)
      Adachi M, Takayanagi N, Takahashi M, Yasuda S, Yoshida S, Mikami M, Nakai A, Saito M, Nakamura K.
    • Organizer
      DCD12(International Conference for Developmental Coordination Disorder)
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Developmental Coordination Disorder trait in Japanese preschoolers impact on parenting stress.2017

    • Author(s)
      Takahashi M, Adachi M, Takayanagi N, Yasuda S, Osato-Kaneda A, Mikami M, Nakai A, Saito M, Kuribayashi M, Nakamura K.
    • Organizer
      DCD12(International Conference for Developmental Coordination Disorder)
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Evaluation of factor structure equivalence of the Developmental Coordination Disorder Questionnaire across genders in Japanese preschool children: HFC study.2017

    • Author(s)
      Tanaka M, Saito M, Kaneda-Osato A, Masuda T, Takayanagi N, Takahashi M, Adachi M, Yasuda S, Yoshida S, Kuribayashi, M, Nakai A, Miyahara M, Nakamura K, Sakamoto Y.
    • Organizer
      DCD12(International Conference for Developmental Coordination Disorder)
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Prevalence and comorbidities of DCD Using DSM-5, comparison of motor and cognitive functions at preschool age in a Japanese community.2017

    • Author(s)
      Saito M, Osato-Kaneda A, Tanaka M, Masuda T, Yoshida S, Sakamoto Y, Matsubara Y, Takayanagi N, Adachi, M, Takahashi M, Yasuda S, Kuribayashi M, Nakai A, Miyahara M, Nakamura K.
    • Organizer
      DCD12(International Conference for Developmental Coordination Disorder)
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] The parental and tescher’s recognition for Developmental Coordination Disorder in preschool-aged children.2017

    • Author(s)
      Mikami M, Saito M, Masuda T, Tanaka M, Osato A, Sakamoto Y, Yoshida S, Takayanagi N, Adachi M, Yasuda S, Kuribayashi M, Nakamura K.
    • Organizer
      DCD12(International Conference for Developmental Coordination Disorder)
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Gaze Abnormality Can Distinguish Between Autism Spectrum Disorder and Typically Developing Children through Screening in 5-Year-Old Children By a Double Blind Study in a Japanese Community Based Population.2017

    • Author(s)
      Saito M, Adachi M, Yoshida S, Yasuda S, Kuribayashi M, Sakamoto Y, Nakamura K, Takayanagi N.
    • Organizer
      IMFAR(International Meeting for Autism Research)
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Prevalence and Comorbidities of Autism Spectrum Disorder and Study of the Developmental Health Checkup in a Japanese Community-Based Population Sample of Five-Year-Old Children.2017

    • Author(s)
      Sakamoto Y, Saito M, Yoshida S, Adachi M, Takayanagi N, Yasuda S, Kuribayashi M, Nakamura K.
    • Organizer
      IMFAR(International Meeting for Autism Research)
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] 地域根差した子どもに包括的な発達支援と臨床心理士の役割2017

    • Author(s)
      足立匡基・高橋芳雄・安田小響・浜田恵・村山恭朗
    • Organizer
      日本心理臨床学会第36回大会
    • Related Report
      2017 Research-status Report
  • [Presentation] スクリーニングツルに基づく児童思春期おけるASD 有病率の推計およびASD傾向と適応状態の関連2016

    • Author(s)
      足立匡基, 高栁伸哉, 安田小響, 吉田恵心, 栗林理人, 大里絢子, 斉藤まなぶ, 中村和彦.
    • Organizer
      第57回日本児童青年精神医学会総会
    • Place of Presentation
      岡山コンベンションセンター(岡山県・岡山市)
    • Year and Date
      2016-10-27
    • Related Report
      2016 Research-status Report
  • [Presentation] 短縮版感覚プロファイルを用いた子どもの感覚の特異性の関連2016

    • Author(s)
      安田小響, 足立匡基, 斉藤まなぶ, 大里絢子, 吉田恵心, 栗林理人, 増田貴人, 髙栁伸哉, 田中勝則, 中村和彦
    • Organizer
      第57回日本児童青年精神医学会総会
    • Place of Presentation
      岡山コンベンションセンター(岡山県・岡山市)
    • Year and Date
      2016-10-27
    • Related Report
      2016 Research-status Report
  • [Presentation] GazeFinde(Kao-TV)を用いた5歳児のASD特性の検討2016

    • Author(s)
      斉藤まなぶ, 坂本由唯, 大里絢子, 吉田恵心, 髙栁伸哉, 足立匡基, 安田小響, 田中勝則, 増田貴人, 栗林理人, 中村和彦
    • Organizer
      第57回日本児童青年精神医学会総会
    • Place of Presentation
      岡山コンベンションセンター(岡山県・岡山市)
    • Year and Date
      2016-10-27
    • Related Report
      2016 Research-status Report
  • [Presentation] 某市5歳児発達健診から見た運動機能と認知機能関係2016

    • Author(s)
      大里絢子, 斉藤まなぶ, 坂本由唯, 吉田恵心, 髙栁伸哉, 足立匡基, 安田小響, 田中勝則, 増田貴人, 栗林理人
    • Organizer
      第57回日本児童青年精神医学会総会
    • Place of Presentation
      岡山コンベンションセンター(岡山県・岡山市)
    • Year and Date
      2016-10-27
    • Related Report
      2016 Research-status Report
  • [Presentation] 発達性協調運動障害への保護者・先生の気づきに関する検討. 第57回日本児童青年精神医学会総会2016

    • Author(s)
      三上美咲, 斉藤まなぶ, 増田貴人, 田中勝則, 大里絢子, 坂本由唯, 吉田恵心, 髙栁伸哉, 足立匡基, 安田小響, 栗林理人, 中村和彦
    • Organizer
      第57回日本児童青年精神医学会総会
    • Place of Presentation
      岡山コンベンションセンター(岡山県・岡山市)
    • Year and Date
      2016-10-27
    • Related Report
      2016 Research-status Report
  • [Presentation] 5歳児の自閉スペクトラム障害におけるVLDL、IGF-1、オキシトシンの診断有用性の検討2016

    • Author(s)
      斉藤まなぶ, 下山修司, 吉田恵心, 坂本由唯, 大里絢子, 高柳伸哉, 足立匡基, 安田小響, 栗林理人, 中村和彦
    • Organizer
      第112回日本精神神経学会学術総会
    • Place of Presentation
      幕張メッセ(千葉県・千葉市)
    • Year and Date
      2016-06-02
    • Related Report
      2016 Research-status Report
  • [Presentation] Applicability of the Autism Spectrum Screening Questionnaire Parent Form to 5-Year-Old Children.2016

    • Author(s)
      Adachi M, Takayanagi N, Yasuda S, Yoshida S, Kuribayashi M, Osato A, Masuda T, Tanaka M, Saito M, Nakamura K.
    • Organizer
      International Society for Autism Research
    • Place of Presentation
      Baltimore(アメリカ合衆国)
    • Year and Date
      2016-05-11
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Prevalence of Autism Spectrum Disorder in a Japanese Community-Based Population Sample of Five-Year-Old Children.2016

    • Author(s)
      Saito M, Takayanagi N, Adachi M, Osato A, Yasuda, S, Masuda, M. Tanaka, S. Yoshida, M. Kuribayashi M, Nakamura K.
    • Organizer
      International Society for Autism Research
    • Place of Presentation
      Baltimore(アメリカ合衆国)
    • Year and Date
      2016-05-11
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Risk and Protective Factors of Depression in Children with ASD Tendency in Japan.2016

    • Author(s)
      Takayanagi N, Adachi A, Yasuda S, Yoshida S, Kuribayashi M, Nakamura.
    • Organizer
      International Society for Autism Research
    • Place of Presentation
      Baltimore(アメリカ合衆国)
    • Year and Date
      2016-05-11
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Remarks] Researchmap

    • URL

      https://researchmap.jp/-------/

    • Related Report
      2018 Annual Research Report
  • [Remarks] Researchgate

    • URL

      https://www.researchgate.net/profile/Masaki_Adachi2

    • Related Report
      2018 Annual Research Report
  • [Remarks] 弘前大学大学院医学研究科附属子どものこころの発達研究センター

    • URL

      http://www.med.hirosaki-u.ac.jp/~kodomono/

    • Related Report
      2018 Annual Research Report 2017 Research-status Report 2016 Research-status Report
  • [Remarks] researchmap

    • URL

      https://researchmap.jp/-------

    • Related Report
      2017 Research-status Report
  • [Remarks] researchmap

    • URL

      http://researchmap.jp/-------/

    • Related Report
      2016 Research-status Report

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Published: 2016-04-21   Modified: 2020-03-30  

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