Fabrication of artificial neural network by reversibly controlling elastic properties of a hydrogel substrate
| Project/Area Number |
16K17499
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Nanobioscience
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| Research Institution | NTT Basic Research Laboratories |
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Principal Investigator |
Tanaka Aya 日本電信電話株式会社NTT物性科学基礎研究所, 機能物質科学研究部, 研究主任 (80564278)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2017: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2016: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
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| Keywords | メカノバイオロジー / 神経細胞 / ハイドロゲル / ヤング率 / 弾性率 / 神経突起形成 / ナノバイオ |
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| Outline of Final Research Achievements |
This research aims to reveal how the mechanical properties of the extracellular microenvironment affect neural network formation in the CNS. Here, I focus on neurite initiation from a cell body, which is known to be the first step towards forming a functional nervous network. For this purpose, stiffness-controlled hydrogel substrates were prepared. It was found that the neurite initiation depended on an elastic properties of the hydrogel substrate. This result provides an insight for developing a scaffold for designing a compliant interface between tissue and a
device such as a brain-machine interface.
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Report
(3 results)
Research Products
(8 results)
