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Fabrication of artificial neural network by reversibly controlling elastic properties of a hydrogel substrate

Research Project

Project/Area Number 16K17499
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Nanobioscience
Research InstitutionNTT Basic Research Laboratories

Principal Investigator

Tanaka Aya  日本電信電話株式会社NTT物性科学基礎研究所, 機能物質科学研究部, 研究主任 (80564278)

Project Period (FY) 2016-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2017: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2016: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Keywordsメカノバイオロジー / 神経細胞 / ハイドロゲル / ヤング率 / 弾性率 / 神経突起形成 / ナノバイオ
Outline of Final Research Achievements

This research aims to reveal how the mechanical properties of the extracellular microenvironment affect neural network formation in the CNS. Here, I focus on neurite initiation from a cell body, which is known to be the first step towards forming a functional nervous network. For this purpose, stiffness-controlled hydrogel substrates were prepared. It was found that the neurite initiation depended on an elastic properties of the hydrogel substrate. This result provides an insight for developing a scaffold for designing a compliant interface between tissue and a
device such as a brain-machine interface.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • Research Products

    (8 results)

All 2018 2017

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (6 results) (of which Int'l Joint Research: 1 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Regulation of neuritogenesis in hippocampal neurons using stiffness of extracellular microenvironment2018

    • Author(s)
      Tanaka Aya、Fujii Yuki、Kasai Nahoko、Okajima Takaharu、Nakashima Hiroshi
    • Journal Title

      PLOS ONE

      Volume: 13 Issue: 2 Pages: e0191928-e0191928

    • DOI

      10.1371/journal.pone.0191928

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] 細胞集団運動測定に利用可能な硬さパターンゲル基板の作製2018

    • Author(s)
      廣野航平,田中あや,藤井裕紀,松本悠暉,中島寛,岡嶋孝治
    • Organizer
      第65回応用物理学会春季学術講演会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 蛍光高分子ゲルを用いた細胞牽引力顕微鏡の開発2018

    • Author(s)
      松本悠暉,田中あや,廣野航平,藤井裕紀,中島寛,岡嶋孝治
    • Organizer
      第65回応用物理学会春季学術講演会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 基板の弾性制御による神経細胞の成長制御2017

    • Author(s)
      田中あや、藤井裕紀、手島哲彦、河西奈保子、岡嶋孝治、中島 寛
    • Organizer
      第66回高分子学会年次大会
    • Place of Presentation
      幕張メッセ(千葉県・千葉市)
    • Year and Date
      2017-05-29
    • Related Report
      2016 Research-status Report
  • [Presentation] 基板の弾性率分布のパターニングによる神経細胞の成長制御2017

    • Author(s)
      田中あや、藤井裕紀、手島哲彦、河西奈保子、岡嶋孝治、中島 寛
    • Organizer
      第64回春季応用物理学会
    • Place of Presentation
      パシフィコ横浜(神奈川県・横浜市)
    • Year and Date
      2017-03-14
    • Related Report
      2016 Research-status Report
  • [Presentation] Mechanical regulation of neurite outgrowth of hippocampal cells by controlling substrate stiffness2017

    • Author(s)
      Aya Tanaka, Yuki Fujii, Nahoko Kasai, Takaharu Okajima, Hiroshi Nakashima
    • Organizer
      MRS fall meeting
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 細胞外微小環境の弾性率による神経突起形成の制御2017

    • Author(s)
      田中あや,藤井裕紀,河西奈保子,岡嶋孝治,中島寛
    • Organizer
      第78回応用物理学会秋季学術講演会
    • Related Report
      2017 Annual Research Report
  • [Patent(Industrial Property Rights)] 細胞培養材料、細胞モデル、及び細胞培養材料の製造方法2017

    • Inventor(s)
      田中あや、手島哲彦、中島寛、岡嶋孝治、藤井裕紀
    • Industrial Property Rights Holder
      日本電信電話株式会社および北海道大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2017-032733
    • Filing Date
      2017-03-18
    • Related Report
      2016 Research-status Report

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Published: 2016-04-21   Modified: 2019-03-29  

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