Dual Catalysis with Photoredox Catalysts for Organic Transformations Mediated by Single-Electron Transfer Processes
| Project/Area Number |
16K17865
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Organic chemistry
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| Research Institution | The University of Tokyo |
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Principal Investigator |
Yoo Woo-Jin 東京大学, 大学院理学系研究科(理学部), 特任助教 (70626077)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | carbon dioxide / multi-component coupling / copper / flourine / lactone / C-H functionalization / silicon / Single-electron transfer / Dual catalysis / Photocatalysis / Radicals |
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| Outline of Final Research Achievements |
I investigated the synthesis of lactones from carbon dioxide and readily available starting materials by two different strategies. The first approach involved combining C-H activation (C-H silylation) chemistry with copper-catalyzed carboxylation reaction to convert benzyl alcohols to phthalides. The second approach involved a sequential trans-hydroalumination and copper-catalyzed carboxylation reaction to convert propargyl alcohols into butenolides.
Finally, I have interest in developing multi-component coupling reactions with carbon dioxide to make complex organic molecules. I found that 1-aryl-2,2-difluoroalkenes can undergo fluorocarboxylation with carbon dioxide and cesium fluoride to provide trifluoromethyl carboxylic acids in good yields.
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| Academic Significance and Societal Importance of the Research Achievements |
Various strategies of utilizing carbon dioxide as a sustainable source of a carbon feedstock to synthesize various value-added organic substrates have been discovered through our studies, and it is anticipated that our finding can be used to sustainably synthesis other complex organic molecules.
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Report
(3 results)
Research Products
(8 results)
