| Project/Area Number |
16K17869
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Organic chemistry
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| Research Institution | Yamaguchi University |
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Principal Investigator |
Kawamoto Takuji 山口大学, 大学院創成科学研究科, 助教 (70756139)
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| Research Collaborator |
SASAKI Rio 山口大学, 大学院創成科学研究科, 大学院生
ORITANI Kyohei 山口大学, 大学院創成科学研究科, 大学院生
SHIMAYA Yudai 山口大学, 大学院創成科学研究科, 大学院生
MII Junya 山口大学, 大学院創成科学研究科, 大学院生
KAWABATA Atsushi 山口大学, 大学院創成科学研究科, 大学院生
KAMIMURA Akio 山口大学, 大学院創成科学研究科, 教授
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | トリフルオロメチル / ラジカル / トリエチルボラン / トリフルオロメタンスルホン酸無水物 / トリフルオロメチル化 / 有機化学 |
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| Outline of Final Research Achievements |
Trifluoromethylated compounds are the most important class of structural motifs, especially in the fields of pharmaceuticals, agrochemicals, and fine chemicals. α-Trifluoromethylated ketones are useful building blocks that can serve as versatile precursors to drug-like compounds. For the preparation of such α-trifluoromethylated ketones, several methods have been developed. All these methods require external trifluoromethyl sources, which often contain large activating groups. In this work, we have developed a novel method using trifluoromethanesulfonic anhydride as the activator for the ketone and as the trifluoromethyl source.
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