| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Outline of Final Research Achievements |
There are many natural products and drugs including chiral spiro-ring. However, the construction of spiro-ring containing a quaternary carbon is more difficult than the spiro ring having a hetero atom. In our laboratory, we developed the new method using organocatalyst to construct the all-carbon quaternary stereocenter or tetrasubstituted carbon by intramolecular Friedel-Crafts type 1.4 addition reaction and oxy-Michel addition. Furthermore, we succeeded to apply these reactions into the total synthesis of (-)-misramine and（-)-(R)-cordiachromene.
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