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Construction of Functional Interfaces based on Precision Polymer Synthesis: Novel Design of Blood-compatible Polymers

Research Project

Project/Area Number 16K17917
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Polymer chemistry
Research InstitutionKyushu University

Principal Investigator

Oda Yukari  九州大学, 工学研究院, 助教 (20625595)

Project Period (FY) 2016-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords高分子膜 / 精密合成 / 血液適合性 / 水 / 界面 / 表面濃縮 / ハイドロゲル / 高分子界面 / 機能性高分子 / 走査プローブ顕微鏡 / ニトロキシド媒介ラジカル重合 / グラフト層 / 表面開始ラジカル重合 / 分岐型高分子 / 高分子合成 / 高分子構造・物性
Outline of Final Research Achievements

Excellent bio-inert properties of polymers are strongly related to aggregation states and dynamics of chains at the water interface. In this study, we prepared a series of well-defined polymer thin films and examined relationship between their structure and physical properties at the water interface, and blood-compatibility. First, a branched polymer grafted with hydrophilic polymer chains was successfully prepared. Its hydrophilic part was preferentially segregated at the outermost surface of the blend films with a linear polymer and effectively prevented protein adsorption on their surfaces. Furthermore, the cross-linked thin films of water-soluble polymers were prepared. The obtained films were thickened in water. The moduli of the hydrogel films near the water interfaces were greatly sensitive to the cross-linking density of the polymers. Diffuse interfaces of the polymer chains at the water interface made it possible to prevent the platelet adhesion on the films.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • Research Products

    (16 results)

All 2018 2017 2016

All Journal Article (5 results) (of which Peer Reviewed: 5 results,  Acknowledgement Compliant: 4 results,  Open Access: 1 results) Presentation (11 results) (of which Int'l Joint Research: 7 results,  Invited: 4 results)

  • [Journal Article] Surface Characterization and Platelet Adhesion on Thin Hydrogel Films of Poly(vinyl ether)2017

    • Author(s)
      Itagaki Nozomi、Oda Yukari、Hirata Toyoaki、Nguyen Hung Kim、Kawaguchi Daisuke、Matsuno Hisao、Tanaka Keiji
    • Journal Title

      Langmuir

      Volume: 33 Issue: 50 Pages: 14332-14339

    • DOI

      10.1021/acs.langmuir.7b03427

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Platelet Adhesion on the Surface of a Simple Poly(vinyl ether)2017

    • Author(s)
      H. Matsuno, R. Tsukamoto, Y. Oda, and K. Tanaka
    • Journal Title

      Polymer

      Volume: 印刷中 Pages: 479-486

    • DOI

      10.1016/j.polymer.2017.01.036

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] A Polymer Interfacial Modifier Synthesized by Living Anionic Polymerization: Incorporation of Inorganic Blocks to Chain Ends2017

    • Author(s)
      K. Yamamoto, T. Hirai, Y. Oda, D. Kawaguchi, H. Matsuno, and K. Tanaka
    • Journal Title

      Macromolecular Chemistry and Physics

      Volume: 印刷中 Issue: 12

    • DOI

      10.1002/macp.201600473

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Surface Segregation of a Branched Polymer with hydrophilic Poly[2-(2-ethoxy)ethoxyethyl vinyl ether] Side Chains2017

    • Author(s)
      S. Sugimoto, Y. Oda, T. Hirata, R. Matsuyama, H. Matsuno, and K. Tanaka
    • Journal Title

      Polymer Chemistry

      Volume: 8 Issue: 3 Pages: 505-510

    • DOI

      10.1039/c6py01984f

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Design of Blood-Compatible Interfaces with Poly(vinyl ether)s2016

    • Author(s)
      Y. Oda, C. Zhang, D. Kawaguchi, H. Matsuno, S. Kanaoka, S. Aoshima, and K. Tanaka
    • Journal Title

      Advanced Materials Interfaces

      Volume: 3 Issue: 12 Pages: 1600034-1600034

    • DOI

      10.1002/admi.201600034

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] Interfacial Properties of Vinyl Polymers with Hydrophilic Side-chains in Water2018

    • Author(s)
      Yukari Oda
    • Organizer
      The Polymer Society of Korea, 2018 Spring Meeting
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] ビニル高分子の界面設計と機能化展開2018

    • Author(s)
      織田ゆか里
    • Organizer
      17-1 高分子表面研究会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Interfacial Properties of Thin Films of Poly(vinyl ether)s with Architectural Design in Water2017

    • Author(s)
      Yukari Oda, Nozomi Itagaki, Shin Sugimoto, Daisuke Kawaguchi, Hisao Matsuno, Keiji Tanaka
    • Organizer
      APS March Meeting 2017
    • Place of Presentation
      New Orleans, USA
    • Year and Date
      2017-03-13
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Interfacial Modification of Polymers with Elemental Blocks2017

    • Author(s)
      Yukari Oda, Kentaro Yamamoto, Daisuke Kawaguchi, Hisao Matsuno, Kensuke Naka, Keiji Tanaka
    • Organizer
      The 2nd International Symposium on Polymeric Materials Based on Element-Blocks
    • Place of Presentation
      京都
    • Year and Date
      2017-01-18
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Bio-inert Modifications of Polymer Films in Water Using Janus-like Macromolecules2017

    • Author(s)
      Yukari Oda, Ryo Awane, Manabu Inutsuka, Hisao Matsuno, Norifumi L. Yamada, Masayuki Haraguchi, Masaaki Ozawa, Keiji Tanaka
    • Organizer
      Polychar2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Interfacial Physical Properties of Bio-inert Polymer Hydrogel Films2017

    • Author(s)
      Yukari Oda, Nozomi Itagaki, Daisuke Kawaguchi, Hisao Matsuno, Keiji Tanaka
    • Organizer
      Japan-Taiwan Bliateral Polymer Symposium (JTBPS2017)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Interfacial Modifications of Thin Films by Preferential Segregation of Janus Macromolecules2017

    • Author(s)
      Yukari Oda, Ryo Awane, Manabu Inutsuka, Hisao Matsuno, Norifumi L. Yamada, Masayuki Haraguchi, Masaaki Ozawa, Keiji Tanaka
    • Organizer
      The 15th International Conference on Advanced Materials (IUMRS-ICAM 2017)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 界面設計に基づく高分子への生体成分の付着制御2017

    • Author(s)
      織田ゆか里
    • Organizer
      日本接着学会第55回年次大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Interfacial Modification with Adhesive Poly(vinyl ether)s in Water2016

    • Author(s)
      Yukari Oda, Ryo Awane, Daisuke Kawaguchi, Hisao Matsuno, Keiji Tanaka
    • Organizer
      KJF International Conference on Organic Materials for Electronics and Photonics 2016 (KJF-ICOMEP 2016)
    • Place of Presentation
      福岡
    • Year and Date
      2016-09-04
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Design of Adhesive Poly(vinyl ether)s for Lubricative Surface Modification2016

    • Author(s)
      Yukari Oda, Ryo Awane, Daisuke Kawaguchi, Keiji Tanaka
    • Organizer
      第65回高分子学会年次大会
    • Place of Presentation
      神戸
    • Year and Date
      2016-05-25
    • Related Report
      2016 Research-status Report
  • [Presentation] ヤヌス型多分岐高分子の表面濃縮挙動による生体不活性表面の構築2016

    • Author(s)
      織田ゆか里, 粟根 諒, 犬束 学, 松野寿生, 山田悟史, 原口将幸, 小澤雅昭, 田中敬二
    • Organizer
      九州地区高分子若手研究会・冬の講演会
    • Place of Presentation
      熊本
    • Related Report
      2016 Research-status Report

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Published: 2016-04-21   Modified: 2019-03-29  

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