| Project/Area Number |
16K17931
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Bio-related chemistry
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| Research Institution | Tokyo Institute of Technology |
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Principal Investigator |
ABE Satoshi 東京工業大学, 生命理工学院, 助教 (40508595)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 多角体 / 酵素 / タンパク質結晶 / カスケード反応 / 結晶工学 |
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| Outline of Final Research Achievements |
In this research, we have synthesized polyhedra mutant, which have a large pore in unit cell by deletion of amino acid residues. We found that positively charged SfGFP is largely encapsulated into Polyhedra crystals than negatively charged SfGFP. We have prepared polyhedra crystal including Lipase enzyme. In future, we will synthesize polyhedra crystals including two enzymes, lipase and alcohol dehydrogenase and investigate the cascade reaction.
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