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Microbial synthesis of functional cationic-polyelectrolyte and preparation of polycationized plastic materials

Research Project

Project/Area Number 16K17961
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Polymer/Textile materials
Research InstitutionNational Institute of Advanced Industrial Science and Technology (2017-2018)
Fukui Prefectural University (2016)

Principal Investigator

Ushimaru Kazunori  国立研究開発法人産業技術総合研究所, 材料・化学領域, 研究員 (10770703)

Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywordsε-ポリリジン / 親水化 / 抗菌材料 / 天然高分子 / ε-ポリ-L-リジン / バイオベースポリマー / 抗菌化 / 細胞接着 / バイオプラスチック / ポリカチオン / 抗菌プラスチック
Outline of Final Research Achievements

In this study, functional natural cationic-polyelectrolyte was synthesized by microbial process and apply the polycation to creation of hydrophilic and functional plastics.
We found a new technique to produce a organo-soluble cationic-polyelectrolyte via a complex formation of the polyelectrolyte with an anionic surfactant. This complex revealed thermoplasticity and antimicrobial activity, thus, we applied the complex for thermoplastic and/or antimicrobial materials.
As for the creation of hydrophilic and functional plastics, it requires further optimization of reaction condition to obtain the desired material.

Academic Significance and Societal Importance of the Research Achievements

本研究では、医用材料や再生医療分野で用いられる細胞培養基材として有用な「親水性・抗菌性・細胞接着性を併せ持つプラスチック材料」の創生を目的として検討を行った。
目的とする機能性プラスチック材料の開発に取り組む中で、微生物由来の水溶性高分子を水に不溶なプラスチック化する技術を見出した。この手法で得た材料は微生物由来の環境調和型材料であると共に、優れた抗菌活性を示す機能性材料であることを見出した。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (2 results)

All 2017

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Acknowledgement Compliant: 1 results) Presentation (1 results)

  • [Journal Article] Antimicrobial Activity of ε-Poly-l-lysine after Forming a Water-Insoluble Complex with an Anionic Surfactant2017

    • Author(s)
      Kazunori Ushimaru, Yoshimitsu Hamano, Hajime Katano
    • Journal Title

      Biomacromolecules

      Volume: 18 Issue: 4 Pages: 1387-1392

    • DOI

      10.1021/acs.biomac.7b00109

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] ε-PLとアニオン性界面活性剤から成るイオン複合体の抗菌材料応用2017

    • Author(s)
      牛丸和乗、濱野吉十、片野肇
    • Organizer
      高分子学会関東支部茨城地区 若手の会交流会
    • Related Report
      2017 Research-status Report

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Published: 2016-04-21   Modified: 2020-03-30  

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