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Development of a biosensor for perioperative monitoring of cardiac marker to prevent postoperative acute myocardial infarction

Research Project

Project/Area Number 16K18112
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Measurement engineering
Research InstitutionTokyo Medical and Dental University

Principal Investigator

TOMA Koji  東京医科歯科大学, 生体材料工学研究所, 助教 (40732269)

Project Period (FY) 2016-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywordsプラズモン / 心筋梗塞 / モニタリング / 免疫センサ / バイオセンサ / 連続測定
Outline of Final Research Achievements

The purpose of this research was to develop an optical biosensor that can be used for perioperative monitoring of cardiac marker to prevent postoperative acute myocardial infarction. In fiscal year 2016, an optical biosensor for repeated measurement was developed, and it was characterized by a model experiment. In fiscal year 2017 year, along with optimizing and tuning the development of the setup and the system, characterization with a model sample, mouse and anti-mouse antibodies, were continued. It showed increase of the sensor output depending on concentration of anti-mouse antibody along with high reproducibility in a repeated measurement of the antibody.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • Research Products

    (3 results)

All 2018 2017

All Presentation (3 results) (of which Int'l Joint Research: 3 results)

  • [Presentation] Continuous antigen sensors "Immunowatchers" for prevention of bioaerosol-associated and acute diseases2018

    • Author(s)
      當麻浩司
    • Organizer
      IBB-Chulalongkorn 4th Joint Symposium
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Regenerable and antibody-immobilized surface architecture on surface plasmon biosensor for continuous immunosensing2017

    • Author(s)
      當麻浩司
    • Organizer
      5th International Conference on Bio-Sensing Technology
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Regeneratable surface plasmon resonance immunosensor for monitoring in medical care and environmental medicine2017

    • Author(s)
      當麻浩司
    • Organizer
      9th International Conference on Molecular Electronics and Bioelectronics (M&BE9)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research

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Published: 2016-04-21   Modified: 2019-03-29  

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