Fabrication of titanium/amorphous carbon micropattern which promotes bone formation

• Project/Area Number: 16K18256
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Structural/Functional materials
• Research Institution: Nagoya University
• Principal Investigator: Hieda Junko 名古屋大学, 工学研究科, 准教授 (40566717)
• Project Period (FY): 2016-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2017: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: チタン / アモルファス炭素 / 微細テクスチャー / 骨形成能

Outline of Final Research Achievements

In this study, in order to obtain good adhesion strength between Ti surface and new bone, Ti/amorphous carbon micropattern was fabricated since amorphous carbon has affinity for osteoblast and Ti has affinity for bone. To fabricate Ti/amorphous carbon micropattern, amorphous carbon films was deposited on Ti substrates by plasma enhanced chemical vapor deposition (CVD). Furthermore, it was immersed in an aqueous solution of fibronectin, which is a cell adhesion protein, and its adsorption was investigated. It was found that vacuum ultraviolet light irradiation increased the adsorption amount of fibronectin to the amorphous carbon film.

Academic Significance and Societal Importance of the Research Achievements

本研究では、高周波やマイクロ波プラズマCVD法を用いて、ダイヤモンドライクカーボン(DLC)や高分子状等、異なる構造のアモルファス炭素膜をTi上に作製し、細胞接着性タンパク質の吸着を調査した。様々な組成・構造のアモルファス炭素膜があり、本研究成果はどのような組成・構造のアモルファス炭素膜が骨形成に有用であるかに対する知見の一つとなることが期待できる。