Research Project
Grant-in-Aid for Young Scientists (B)
Lactobacillus antri activates the gut immune system and promotes IgA production. It is considered that the multivalency of the binding between the bacterial components serving as ligands and the receptor expressed on the immune cell and the duration time of the interaction are related to the IgA-enhancing effect. Therefore, the interaction between the cells and the Toll-like receptor (TLR) 2 was analyzed kinetically using the surface plasmon resonance method. The interaction with TLR2 of the bacterial cells which digested the ligand components by enzymatic treatment and attenuated the IgA-enhancing effect resulted in increase of the dissociation rate. It was revealed that the duration time of the interaction between the bacterial cells and TLR2 was an important factor of the strength of the IgA-enhancing effect.
All 2018 2017 2016
All Journal Article (3 results) (of which Peer Reviewed: 2 results, Open Access: 1 results) Presentation (4 results) (of which Int'l Joint Research: 1 results, Invited: 1 results) Book (1 results)
Bioscience of Microbiota, Food and Health
Volume: 36 Issue: 1 Pages: 17-25
10.12938/bmfh.BMFH-2016-015
130005303580
日本生物工学会誌
Volume: 95 Pages: 83-83
生物工学会誌
Volume: 95 Pages: 38-38
