| Project/Area Number |
16K18359
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurophysiology / General neuroscience
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| Research Institution | University of Tsukuba |
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Principal Investigator |
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| Project Period (FY) |
2016-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2019: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2018: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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| Keywords | 新生ニューロン / 記憶 / 睡眠 / 超小型脳内視鏡 / レム睡眠 / 光遺伝学 / PTSD / 行動神経科学 |
|---|
| Outline of Final Research Achievements |
Neurogenesis, the process by which new neurons are formed, takes place in the hippocampus throughout the lifespan of animals, including humans. At present, little is known about the contribution of ABNs to memory formation during sleep. In this project, we have revealed that adult-born neurons (ABNs) in the hippocampus, which is a brain region associated with memory, are responsible for memory consolidation during REM sleep. Our findings may lead to a deeper understanding of how memories are formed, retrieved, and consolidated, and could facilitate the development of new treatments for memory disorders using the self-regeneration potential of human brain.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究は、大人の脳内にごく僅かに残る再生能力が、睡眠中に記憶の定着に必要であることを明らかにしました。今後、大人の脳内で新生ニューロンが睡眠中にどのように恐怖記憶を定着させるかを解明することで、脳が持つ再生能力を高め、アルツハイマー病などの神経が失われる病気や、PTSDなどの記憶処理に異常を来す疾患に対する新しい治療法に開発に応用できるものと期待されます。
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