Memory trace consolidated by new-born neurons
Project/Area Number |
16K18359
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Neurophysiology / General neuroscience
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Research Institution | University of Tsukuba |
Principal Investigator |
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Project Period (FY) |
2016-04-01 – 2020-03-31
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Project Status |
Completed (Fiscal Year 2019)
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Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2019: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2018: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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Keywords | 新生ニューロン / 記憶 / 睡眠 / 超小型脳内視鏡 / レム睡眠 / 光遺伝学 / PTSD / 行動神経科学 |
Outline of Final Research Achievements |
Neurogenesis, the process by which new neurons are formed, takes place in the hippocampus throughout the lifespan of animals, including humans. At present, little is known about the contribution of ABNs to memory formation during sleep. In this project, we have revealed that adult-born neurons (ABNs) in the hippocampus, which is a brain region associated with memory, are responsible for memory consolidation during REM sleep. Our findings may lead to a deeper understanding of how memories are formed, retrieved, and consolidated, and could facilitate the development of new treatments for memory disorders using the self-regeneration potential of human brain.
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Academic Significance and Societal Importance of the Research Achievements |
本研究は、大人の脳内にごく僅かに残る再生能力が、睡眠中に記憶の定着に必要であることを明らかにしました。今後、大人の脳内で新生ニューロンが睡眠中にどのように恐怖記憶を定着させるかを解明することで、脳が持つ再生能力を高め、アルツハイマー病などの神経が失われる病気や、PTSDなどの記憶処理に異常を来す疾患に対する新しい治療法に開発に応用できるものと期待されます。
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Report
(5 results)
Research Products
(54 results)
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[Journal Article] Sparse activity of hippocampal adult-born neurons during REM sleep is necessary for memory consolidation2020
Author(s)
Kumar D, Koyanagi I, Carrier-Ruiz A, Vergara P, Srinivasan S, Sugaya Y, Kasuya M, Yu TS, Vogt K, Muratani M, Ohnishi T, Singh S, Teixeira CM, Cherasse Y, Naoi T, Wang Y, Nondhalee P, Osman BAH, Kaneko N, Sawamoto K, Kernie SG, Sakurai T, McHugh TJ, Kano M, Yanagisawa M, Sakaguchi M
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Journal Title
Neuron
Volume: 107
Issue: 3
Pages: 1-14
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Presentation] The role of adult born neurons in memory consolidation during sleep-wake cycles2016
Author(s)
Kumar D, Hayashi M, Hayashi X, Changarathil G, Wintzer M, McHugh TJ, Sakurai T, Yanagisawa M, Sakaguchi M
Organizer
Society for Neuroscience
Place of Presentation
Convention Center, San Diego, USA
Year and Date
2016-11-12
Related Report
Int'l Joint Research
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[Presentation] Function of the adult-born neurons in memory consolidation during sleep2016
Author(s)
Masanori Sakaguchi, Masanobu Hayashi, Makoto Oishi, Xifang Hayashi, Boran Osman, Sima Singh, Marie Wintzer, Thomas J. McHugh, Takeshi Sakurai, Masashi Yanagisawa, Deependra Kumar
Organizer
RIKEN PDFA Pizza and Science Seminars
Place of Presentation
RIKEN BSI, 埼玉県和光市
Year and Date
2016-10-19
Related Report
Invited
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[Presentation] 成体脳で新生するニューロンが、睡眠中の記憶の固定化に果たす役割り2016
Author(s)
坂口昌徳, Deependra Kumar, 林政信, 林細芳, Gopakumar Changarathil, Marie Wintzer, Thomas J. McHugh, 櫻井武, 柳沢正史
Organizer
成体脳で新生するニューロンが、睡眠中の記憶の固定化に果たす役割り
Place of Presentation
京王プラザホテル、東京都新宿区
Year and Date
2016-07-08
Related Report
Invited
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[Presentation] The activity of adult born neurons are necessary for memory consolidation during sleep2016
Author(s)
Sakaguchi M, Kumar D, Hayashi M, Hayashi X, Changarathil G, Singh S, Wintzer M, McHugh TJ, Sakurai T, Yanagisawa M
Organizer
NCTC seminar
Place of Presentation
National Chiao-Tung Univ, Hsinchu, Taiwan
Year and Date
2016-05-26
Related Report
Invited
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