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Regulation of innate olfactory behavior by genetic manipulation of Bcl11b gene

Research Project

Project/Area Number 16K18361
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Neurophysiology / General neuroscience
Research InstitutionTokyo Institute of Technology

Principal Investigator

Enomoto Takayuki  東京工業大学, 生命理工学院, 研究員 (70635680)

Research Collaborator Hirota Junji  
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords本能行動 / 遺伝子操作 / 嗅覚システム / 神経回路 / 細胞分化 / 転写因子 / 嗅覚 / 細胞運命制御 / 神経回路形成 / 神経伝達 / 細胞分化制御 / 神経科学 / 発生・分化 / 脳・神経 / 動物 / 発現制御
Outline of Final Research Achievements

Olfaction is important for the survival of animals. Olfactory sensory neurons (OSNs) are subdivided into two types, which detect odorous chemicals from the external environment. The zinc finger transcription factor Bcl11b regulates a cell fate determination of two OSN-types in the development. In this study, we examined physiological and behavioral responses to odorants on OSN-specific loss-of- and gain-of-Bcl11b function mutant mice. From analyses of these mutant mice, we demonstrate that the changes of peripheral neural input influences on an innate olfactory aversion behavior in mice.

Academic Significance and Societal Importance of the Research Achievements

本研究では、嗅覚系感覚神経細胞の分化において異なる種類の細胞への運命決定を制御している”転写因子Bcl11b”を中心とした分子メカニズムの一端と、末梢の感覚神経細胞の産生を制御することによって匂い刺激に対する神経応答やその個体の行動にまで影響を与えることを明らかにした。本研究成果は、動物が外環境からの匂いによって本能的に誘導される行動を制御する神経基盤の学術的な理解に寄与すると考えられる。心地よい匂いや不快な匂いは直接的に感情に作用するため、ヒトにおいても近年急増する精神疾患の1つである気分障害の症状緩和にも本研究の知見が役に立つことが期待できる。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (4 results)

All 2017 Other

All Int'l Joint Research (2 results) Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (1 results)

  • [Int'l Joint Research] Monell Chemical Senses Center(米国)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] Monell Chemical Senses Center(米国)

    • Related Report
      2017 Research-status Report
  • [Journal Article] A long-range cis-regulatory element for class I odorant receptor genes2017

    • Author(s)
      Iwata Tetsuo、Niimura Yoshihito、Kobayashi Chizuru、Shirakawa Daichi、Suzuki Hikoyu、Enomoto Takayuki、Touhara Kazushige、Yoshihara Yoshihiro、Hirota Junji
    • Journal Title

      Nature Communications

      Volume: 8 Issue: 1 Pages: 1-12

    • DOI

      10.1038/s41467-017-00870-4

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 嗅神経細胞分化の遺伝学的操作による本能的な忌避行動の制御2017

    • Author(s)
      榎本孝幸
    • Organizer
      第4回ケモビ研究会
    • Place of Presentation
      岩手鶯宿温泉 赤い風車
    • Year and Date
      2017-02-17
    • Related Report
      2016 Research-status Report

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Published: 2016-04-21   Modified: 2022-02-21  

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