Functional mapping of orbitofrontal-subcortical projections

• Project/Area Number: 16K18380
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Nerve anatomy/Neuropathology
• Research Institution: Doshisha University
• Principal Investigator: Hirokawa Junya 同志社大学, 研究開発推進機構, 准教授 (40546470)
• Research Collaborator: OHNUKI Tomoya ; OSAKO Yuma
• Project Period (FY): 2016-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2016: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 光遺伝学 / 意思決定 / 眼窩前頭皮質 / 線条体 / 腹側被蓋野 / 腹側線条体 / 神経科学 / 生理学 / 行動学 / ウィルス / 脳・神経

Outline of Final Research Achievements

Prefrontal cortex projects various brain areas to control decision makings. We took advantage of newly developed method called "optognetic tagging" to investigate the basic principal underlying information sorting from prefrontal cortex to subcortical areas. When animals face in difficult decisions, they tend to be biased by their history of success. We found that neurons in the oritofrontal-striatal pathways specifically show working memory-like sustained activity encoding outcome of the previous decision to the next trials. The results provide an insight that targeting specific projection pathways to treat specific psychiatric disorders such as drug addictions may be valid.

Research Products

• [Int'l Joint Research] コールド・スプリング・ハーバー研究所(米国)
• [Int'l Joint Research] コールド・スプリング・ハーバー研究所(米国)
• [Presentation] Differential routing of reinforcement signals from orbitofrontal cortex to striatum depending on environmental uncertainty (2017)
  • Author(s): Junya Hirokawa, Shujing Li, Alex Vaughan, Jean Pie, Laura Desban, Yuma Osako, Tomoya Ohnuki, Hiroyuki Manabe, Yoshio Sakurai and Adam Kepecs
  • Organizer: 北米神経科学学会
  • Place of Presentation: ワシントンDC（アメリカ合衆国）
  • Year and Date: 2017-11-11
  • Int'l Joint Research
• [Presentation] 眼窩前頭皮質から線条体への投射細胞は環境の不確実性に依存して強化信号を伝達する (2017)
  • Author(s): 廣川純也, Shujing Li, Alex Vaughan, Jean Pie, Laura Desban, 大迫優真, 大貫朋也, 眞部寛之, 櫻井芳雄 、Adam Kepecs
  • Organizer: 第40回日本神経科学大会
  • Place of Presentation: 幕張メッセ（千葉県・幕張市）
  • Year and Date: 2017-07-20
• [Presentation] Differential routing of reinforcement signals from orbitofrontal cortex to striatum depending on environmental uncertainty. (2017)
  • Author(s): Hirokawa, J., Li, S., Vaughan, A., Pie, J., Desban, L., Osako, Y., Ohnuki, T., Manabe, H., Sakurai, Y., and Kepecs, A.
  • Organizer: 47th Society for Neuroscience Annual Meeting
  • Int'l Joint Research
• [Presentation] 眼窩前頭皮質から線条体への投射細胞は環境の不確実性に依存して強化信号を伝達する (2017)
  • Author(s): 廣川純也・Li Shujing., Vaughan, Alex., Pie, Lambert, Jean., Desban, Laura,. 大迫優真・大貫朋哉・眞部寛之・櫻井芳雄
  • Organizer: 第40回日本神経科学大会
• [Presentation] Critical role of primary visual cortex in integration of perceptual and value-based decision making. (2017)
  • Author(s): Yuma Osako, Yoshio Sakurai and Junya Hirokawa
  • Organizer: The 44th Naito conference Decision Making in the Brain―Motivation, Prediction, and Learning (2017) 3.10. - 6, Sapporo Hokkaido (Japan)
  • Int'l Joint Research
• [Presentation] 視覚的気づきに重要な神経回路メカニズムの解明. (2016)
  • Author(s): 大迫優真・櫻井芳雄・廣川純也
  • Organizer: 第25回海馬と高次脳機能学会
  • Place of Presentation: 同志社大学（京都府・京都市）
  • Year and Date: 2016-10-02
• [Presentation] 眼窩前頭皮質における意思決定要因のカテゴリー的表象 (2016)
  • Author(s): 廣川純也・Alex Vaughan・Adam Kepecs
  • Organizer: 第39回日本神経科学大会
  • Place of Presentation: パシフィコ横浜（神奈川県・横浜市）
  • Year and Date: 2016-07-20
• [Presentation] 報酬確率学習課題中の海馬における神経表象 (2016)
  • Author(s): 高橋裕美・廣川純也・高橋晋・櫻井芳雄
  • Organizer: 第39回日本神経科学大会
  • Place of Presentation: パシフィコ横浜（神奈川県・横浜市）
  • Year and Date: 2016-07-20
• [Remarks] Biorxiv（プレプリントサーバ）
  • URL: https://doi.org/10.1101/135707
• [Remarks] Biorxiv（プレプリントサーバ）
  • URL: https://doi.org/10.1101/241125