Importance of histamine metabolizing enzyme in the brain
| Project/Area Number |
16K18389
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurochemistry/Neuropharmacology
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | ヒスタミン / ヒスタミン代謝酵素 / ヒスタミン神経系 |
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| Outline of Final Research Achievements |
HIstamine acts as a neurotransmitter in the central nervous system. In this study,I examined the importance of a histamine metabolizing enzyme for brain functions. I revealed the essential role of this enzyme in the regulation of brain histamine and the contribution to brain functions such as sleep-wake cycle and aggression. Previous reports showed that brain histamine concentration was decreased in various brain diseases. Thus, I tried to develop new inhibitors against the histamine metabolizing enzyme to increase brain histamine concentration. I have confirmed that several compounds have sufficient inhibitory effects on the histamine metabolizing enzyme.
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Report
(3 results)
Research Products
(18 results)
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[Journal Article] Induced histamine regulates Ni elution from an implanted Ni wire in mice by downregulating neutrophil migration.2017
Author(s)
Kishimoto Y, Asakawa S, Sato T, Takano T, Nakajyo T, Mizuno N, Segawa R, Yoshikawa T, Hiratsuka M, Yanai K, Ohtsu H, Hirasawa N.
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Journal Title
Exp Dermatol
Volume: 印刷中
Issue: 10
Pages: 868-874
DOI
Related Report
Peer Reviewed
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