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Dysregulation of P2 receptor signals causes pathogenesis of glaucoma

Research Project

Project/Area Number 16K18390
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Neurochemistry/Neuropharmacology
Research InstitutionUniversity of Yamanashi

Principal Investigator

SHINOZAKI Youichi  山梨大学, 大学院総合研究部, 講師 (10443772)

Project Period (FY) 2016-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Keywords緑内障 / P2受容体 / 網膜 / 神経傷害 / P2Y6受容体 / 眼房水 / 眼圧 / 毛様体突起 / ATP / P2Y6 / glaucoma / retina / neurodegeneration / neuroprotection / purinergic / neuropathy / RGC / 細胞死
Outline of Final Research Achievements

Glaucoma is an optic neuropathy characterized by progressive degeneration of retinal ganglion cells (RGCs) and visual loss.We report that the P2Y6 receptor is critical for lowering IOP and that ablation of the P2Y6 gene in mice (P2Y6KO) results in hypertensive glaucoma-like optic neuropathy.The P2Y6 receptor was expressed in nonpigmented epithelial cells of the ciliary body and controlled aqueous humor dynamics. P2Y6KO mice exhibited sustained elevation of IOP, age-dependent damage to the optic nerve, thinning of ganglion cell plus inner plexiform layers, and a reduction of RGC numbers.In summary, our data show that dysfunctional purinergic signaling causes IOP dysregulation, resulting in glaucomatous optic neuropathy.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • Research Products

    (25 results)

All 2017 2016 Other

All Int'l Joint Research (2 results) Journal Article (3 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 3 results,  Open Access: 3 results) Presentation (15 results) (of which Int'l Joint Research: 1 results) Remarks (4 results) Patent(Industrial Property Rights) (1 results)

  • [Int'l Joint Research] Universite Libre de Bruxelles(ベルギー)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research]

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Purinergic dysregulation causes hypertensive glaucoma-like optic neuropathy.2017

    • Author(s)
      Shinozaki Y, Kashiwagi K, Namekata K, Takeda A, Ohno N, Robaye B, Harada T, Iwata T, *Koizumi S
    • Journal Title

      JCI Insight

      Volume: 2 Issue: 19

    • DOI

      10.1172/jci.insight.93456

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Transformation of Astrocytes to a Neuroprotective Phenotype by Microglia via P2Y1 Receptor Downregulation.2017

    • Author(s)
      Shinozaki Y, Shibata K, Yoshida K, Shigetomi E, Gachet C, Ikenaka K, Tanaka KF, Koizumi S.
    • Journal Title

      Cell Rep

      Volume: 19 Issue: 6 Pages: 1151-1164

    • DOI

      10.1016/j.celrep.2017.04.047

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Transformation of astrocytes to a neuroprotective phenotype by microglia via P2Y1 receptor down-regulation2017

    • Author(s)
      Y.Shinozaki, K. Shibata, K. Yoshida, E. Shigetomi, C. Gachet, K. Ikenaka, KF. Tanaka and S. Koizumi
    • Journal Title

      Cell Reports

      Volume: 印刷中

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] Pathogenic roles of P2 receptors dysregulation in hypertensive glaucoma2017

    • Author(s)
      篠崎陽一、柏木賢治、行方和彦、大野伸彦、武田明子、柏木賢治、原田高幸、小泉修一
    • Organizer
      第90回日本薬理学会年会
    • Place of Presentation
      長崎ブリックホール (長崎県・長崎市)
    • Year and Date
      2017-03-15
    • Related Report
      2016 Research-status Report
  • [Presentation] Microglia-derived TNFα damages RGCs in glaucoma model mouse2017

    • Author(s)
      武田明子、篠崎陽一、柏木賢治、小泉修一
    • Organizer
      第90回日本薬理学会年会
    • Place of Presentation
      長崎ブリックホール (長崎県・長崎市)
    • Year and Date
      2017-03-15
    • Related Report
      2016 Research-status Report
  • [Presentation] Dysregulation in purinergic signaling causes hypertensive glaucoma-like optic neuropathy2017

    • Author(s)
      Shinozaki Y, Kashiwagi K, Takeda A, Ohno N, Koizumi S
    • Organizer
      ARVO2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 眼内プリンシグナル異常による高眼圧及び緑内障症状の誘発2017

    • Author(s)
      篠崎陽一、柏木賢治、行方和彦、武田明子、大野伸彦、原田高幸、岩田岳、小泉修一
    • Organizer
      第10回Retinal Research Meeting
    • Related Report
      2017 Annual Research Report
  • [Presentation] 脳の高次機能の解明に向けた脳神経系の近接場光イメージング2017

    • Author(s)
      櫻井杏梨、酒井優、篠崎陽一、柴田圭輔、繁冨英治、小泉修一、居島薫、堀裕和、小林潔
    • Organizer
      第24回ナノオプティクス研究グループ討論会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Microglia-mediated transformation of neuroprotective astrocytes2017

    • Author(s)
      篠崎陽一、吉田慶太郎、池中一裕、田中謙二、小泉修一
    • Organizer
      第22回グリア研究会
    • Related Report
      2017 Annual Research Report
  • [Presentation] P2受容体シグナルの異常は慢性的な高眼圧及び緑内障様の症状を誘導する2017

    • Author(s)
      篠崎陽一、柏木賢治、行方和彦、武田明子、大野伸彦、原田高幸、岩田岳、小泉修一
    • Organizer
      第9回若手神経保護の会 (NMYR)
    • Related Report
      2017 Annual Research Report
  • [Presentation] Microglia induce neuroprotective astrocytes via down-regulation of P2Y1 receptors2017

    • Author(s)
      篠崎陽一、柴田圭輔、繁冨英治、吉田慶太郎、池中一裕、田中謙二、小泉修一
    • Organizer
      第39回日本生物学的精神医学会/第47回日本神経精神薬理学会合同大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Microglia-induced astrocytic P2Y1 receptor down-regulation causes neuroprotective astrocyte scar formation2017

    • Author(s)
      篠崎陽一、柴田圭輔、繁冨英治、吉田慶太郎、池中一裕、田中謙二、小泉修一
    • Organizer
      第60回日本神経化学会年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ミクログリアは脳損傷後の神経保護的アストロサイトを誘導する2017

    • Author(s)
      篠崎陽一、柴田圭輔、吉田慶太郎、繁冨英治、田中謙二、小泉修一
    • Organizer
      第136回日本薬理学会関東部会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Dysregulation in P2Y6 reecptor causes hypertensive glaucoma-like phenotypes in mice2016

    • Author(s)
      篠崎陽一、柏木賢治、武田明子、小泉修一
    • Organizer
      The 20th Japan Purine Club Meeting
    • Place of Presentation
      東京慈恵会医科大学 (東京都・港区)
    • Year and Date
      2016-10-26
    • Related Report
      2016 Research-status Report
  • [Presentation] Dysregulated P2 receptor signaling causes optic neuropathy via elevation of intarocular pressure2016

    • Author(s)
      篠崎陽一、武田明子、柏木賢治、小泉修一
    • Organizer
      第59回日本神経化学会/第38回日本生物学的精神医学会合同年会
    • Place of Presentation
      福岡国際会議場 (福岡県・福岡市)
    • Year and Date
      2016-09-07
    • Related Report
      2016 Research-status Report
  • [Presentation] Pathogenic role of retinal microglia in excitotoxicity-induced optic neurodegeneration2016

    • Author(s)
      武田明子、篠崎陽一、柏木賢治、小泉修一
    • Organizer
      第59回日本神経化学会/第38回日本生物学的精神医学会合同年会
    • Place of Presentation
      福岡国際会議場 (福岡県・福岡市)
    • Year and Date
      2016-09-07
    • Related Report
      2016 Research-status Report
  • [Presentation] P2受容体は眼房水産生調節を負に制御する2016

    • Author(s)
      篠崎陽一、武田明子、柏木賢治、小泉修一
    • Organizer
      第134回日本薬理学会関東部会
    • Place of Presentation
      国際医療福祉大学 (栃木県・大田原市)
    • Related Report
      2016 Research-status Report
  • [Presentation] NMDA誘発緑内障モデルにおけるミクログリア依存的RGC傷害メカニズムの解明2016

    • Author(s)
      武田明子、篠崎陽一、柏木賢治、小泉修一
    • Organizer
      第134回日本薬理学会関東部会
    • Place of Presentation
      国際医療福祉大学 (栃木県・大田原市)
    • Related Report
      2016 Research-status Report
  • [Remarks] 篠崎陽一HP

    • URL

      http://www.ccn.yamanashi.ac.jp/~yshinozaki/Home.html

    • Related Report
      2017 Annual Research Report
  • [Remarks] 山梨大学医学部 News

    • URL

      http://www.med.yamanashi.ac.jp/news/262.html

    • Related Report
      2016 Research-status Report
  • [Remarks] 研究代表者HP

    • URL

      http://www.med.yamanashi.ac.jp/clinical_basic/pharmaco/1-Japanese/home.html

    • Related Report
      2016 Research-status Report
  • [Remarks] 研究代表者所属研究室HP

    • URL

      http://www.med.yamanashi.ac.jp/clinical_basic/pharmaco/1-Japanese/home.html

    • Related Report
      2016 Research-status Report
  • [Patent(Industrial Property Rights)] 緑内障モデル、評価対象薬剤の緑内障予防乃至治療効果の評価方法、及び眼圧調整剤2016

    • Inventor(s)
      小泉修一 、篠崎陽一 、柏木賢治
    • Industrial Property Rights Holder
      小泉修一 、篠崎陽一 、柏木賢治
    • Industrial Property Rights Type
      特許
    • Filing Date
      2016
    • Acquisition Date
      2017
    • Related Report
      2017 Annual Research Report

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Published: 2016-04-21   Modified: 2019-03-29  

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