| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Outline of Final Research Achievements |
It has considered that immune system is a major contributor to proliferation and differentiation of neural stem cells during brain development. However, molecular mechanism of neural stem cell modulation by immune system remains unclear. In this study, I investigate the role of immune cells in brain development. I examined the subtype and amount of immune cells in developing brain, and found that B-1 cells are abundant in neonatal brain. B-1 cells mediate oligodendrocyte development and myelination of axons by producing natural antibody.
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