Molecular mechanism for modulation of neural stem cell activity by neuro-immune interaction
Project/Area Number |
16K18394
|
Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Neurochemistry/Neuropharmacology
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Research Institution | Osaka University |
Principal Investigator |
Tanabe Shogo 大阪大学, 医学系研究科, 特任助教(常勤) (40772166)
|
Project Period (FY) |
2016-04-01 – 2018-03-31
|
Project Status |
Completed (Fiscal Year 2017)
|
Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
|
Keywords | 神経発生 / オリゴデンドロサイト / 脳発達 / 免疫 / 神経科学 |
Outline of Final Research Achievements |
It has considered that immune system is a major contributor to proliferation and differentiation of neural stem cells during brain development. However, molecular mechanism of neural stem cell modulation by immune system remains unclear. In this study, I investigate the role of immune cells in brain development. I examined the subtype and amount of immune cells in developing brain, and found that B-1 cells are abundant in neonatal brain. B-1 cells mediate oligodendrocyte development and myelination of axons by producing natural antibody.
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Report
(3 results)
Research Products
(4 results)