| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Outline of Final Research Achievements |
Previous studies have shown the robust involvement of endoplasmic reticulum (ER) dysfunctions and ER stress in the development of various diseases such as neurodegenerative disorders. However, the molecular entities linking ER stress with the pathogenesis of these diseases have been unexplored. We identified the small peptide fragments generated from ER stress sensors ATF6 and OASIS family members in an ER stress-dependent manner. The fragments are hydrophobic, highly aggregable and form fibrils. The small peptides also promote the fibrilization of amyloid β. These data indicate that the small peptides might be key molecules linking between ER stress and the pathogenesis of neurodegenerative diseases
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