| Project/Area Number |
16K18407
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Laboratory animal science
|
|---|
| Research Institution | Central Institute for Experimental Animals |
|---|
Principal Investigator |
INOUE Takashi 公益財団法人実験動物中央研究所, マーモセット研究部, 室長 (60465937)
|
|---|
| Research Collaborator |
NOZU Ryoko
SATO Kenya
SASAKI Emi
|
|---|
| Project Period (FY) |
2016-04-01 – 2018-03-31
|
| Project Status |
Completed (Fiscal Year 2017)
|
| Budget Amount *help |
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
|---|
| Keywords | マーモセット / FMT / 腸内細菌 / Clostridium difficile / 非ヒト霊長類 / 実験動物 / 糞便微生物叢移植 / 疾患モデル / 霊長類 |
|---|
| Outline of Final Research Achievements |
Therapeutic effect of fecal microbiota transplantation (FMT) was assessed using common marmosets as a nonhuman primate model. FMT therapy resulted in ameliorating diarrhea, weight loss, hypoalbuminemia and anemia in some chronic diarrhea cases of marmosets. FMT also tended to cure recurrent Clostridium difficile infection in marmosets. Analysis of fecal bacterial flora based on the 16S rRNA gene showed shifts of bacterial composition in the animals after FMT, implying that FMT therapy cured dysbiosis related to these intestinal diseases.
|
