| Project/Area Number |
16K18413
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Tumor biology
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| Research Institution | University of Toyama |
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Principal Investigator |
Yokoyama Satoru 富山大学, 和漢医薬学総合研究所, 助教 (90613498)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | melanoma / 悪性黒色腫 / SOX10 / PD-L1 / 転写因子 / 癌 / 発現制御 |
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| Outline of Final Research Achievements |
The number of melanoma patients is gradually increasing in Japan, and the prognosis is very poor with a 5-year survival rate of less than 20% in the case of metastatic melanoma. In addition, the chemotherapy and radiotherapy are not effective in melanoma; therefore, a new therapeutic strategy is required. In this study, we performed the functional analysis of transcription factor, SOX10, which is highly expressed in melanoma.
Under this research project, we identified 1) the regulation mechanism of PD-L1 in lung cancer, and 2) the induction of apoptosis by Coptidis Rhizoma through BAX/BAK in melanoma.
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