Escaping system from anti-tumor immunity of sphere-foriming cancer cell

Research Project

Project/Area Number	16K18416
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Tumor biology
Research Institution	Osaka University
Principal Investigator	Saga Kotaro 大阪大学, 医学系研究科, 助教 (00563389)
Project Period (FY)	2016-04-01 – 2018-03-31
Project Status	Completed (Fiscal Year 2017)
Budget Amount *help	¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000) Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000) Fiscal Year 2016: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords	sphere-forming cancer / スフィア / 抗腫瘍免疫
Outline of Final Research Achievements	In this research, it was investigated a mechanism of escaping system from NK cell attack in sphere-forming prostate cancer cells. Sphere-forming prostate cancer cells (DU145 and PC3) highly expressed NANOG, therefore NANOG-overexpressing DU145 was generated. It was revealed that NANOG-overexpressing DU145 escaped from NK cell attack by ICAM1 downregulation. Moreover, the escaping ability from NK cell attack of sphere-forming DU145 was inhibited by ICAM1 overexpression. Therefore, it was revealed that sphere-forming DU145 had escaping system from NK cell attack by NANOG overexpressing-mediated ICAM1 downregulation.

Report

(3 results)