Escaping system from anti-tumor immunity of sphere-foriming cancer cell
| Project/Area Number |
16K18416
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Tumor biology
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| Research Institution | Osaka University |
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Principal Investigator |
Saga Kotaro 大阪大学, 医学系研究科, 助教 (00563389)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | sphere-forming cancer / スフィア / 抗腫瘍免疫 |
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| Outline of Final Research Achievements |
In this research, it was investigated a mechanism of escaping system from NK cell attack in sphere-forming prostate cancer cells. Sphere-forming prostate cancer cells (DU145 and PC3) highly expressed NANOG, therefore NANOG-overexpressing DU145 was generated. It was revealed that NANOG-overexpressing DU145 escaped from NK cell attack by ICAM1 downregulation. Moreover, the escaping ability from NK cell attack of sphere-forming DU145 was inhibited by ICAM1 overexpression. Therefore, it was revealed that sphere-forming DU145 had escaping system from NK cell attack by NANOG overexpressing-mediated ICAM1 downregulation.
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Report
(3 results)
Research Products
(1 results)
