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Microbiome analysis and the relation with epigenome abnormality and immune response using U.S. and Japanese gastrointestinal cancers

Research Project

Project/Area Number 16K18423
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Tumor biology
Research InstitutionSapporo Medical University

Principal Investigator

Mitsuhashi Kei  札幌医科大学, 医学部, 助教 (70772127)

Research Collaborator Nosho Katsuhiko  札幌医科大学, 医学部, 講師 (10597339)
Project Period (FY) 2016-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywordsmicrobiome / Fusobacterium / 膵癌 / 消化器癌 / エピゲノム
Outline of Final Research Achievements

Fusobacterium species were detected in pancreatic cancer tissue. Although no significant association was found between Fusobacterium species and molecular alterations of pancreatic cancers, the tumor Fusobacterium species status was independently associated with shorter survival of pancreatic cancer. Thus, our data suggest that tumor Fusobacterium species is a promising biomarker of pancreatic cancer and could open up exciting opportunities to improve our understanding of the pathogenesis of this fatal disease.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • Research Products

    (3 results)

All 2018 2016

All Journal Article (1 results) Presentation (2 results)

  • [Journal Article] 大腸発癌と腸内細菌 -Serrated pathwayとの関りについて2018

    • Author(s)
      能正勝彦、三橋慧、仲瀬裕志
    • Journal Title

      医学のあゆみ

      Volume: 264 Pages: 71-75

    • Related Report
      2017 Annual Research Report
  • [Presentation] 大腸癌の発育進展におけるFusobacterium属の役割とエピゲノム異常、免疫応答との関連2018

    • Author(s)
      能正勝彦、三橋慧
    • Organizer
      第14回日本消化管学会総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 消化器癌におけるFusobacterium属の陽性率と臨床病理・分子生物学的因子との関連2016

    • Author(s)
      三橋 慧
    • Organizer
      第27回日本消化器癌発生学会総会
    • Place of Presentation
      城山観光ホテル(鹿児島県鹿児島市)
    • Year and Date
      2016-09-15
    • Related Report
      2016 Research-status Report

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Published: 2016-04-21   Modified: 2019-03-29  

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