Investigation of mechanisms for the regulation of CD8 T cell exhaustion by type 2 diabetic drug, metfromin
Project/Area Number |
16K18452
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Tumor therapeutics
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Research Institution | Okayama University |
Principal Investigator |
Eikawa Shingo 岡山大学, 医歯薬学総合研究科, 助教 (40635265)
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Project Period (FY) |
2016-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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Keywords | CD8 T細胞 / 代謝免疫 / メトホルミン / 好気的解糖 / グルコース / アミノ酸 / 2型糖尿病薬メトホルミン / 解糖系 / CD8T細胞 / エフェクター / がん免疫 / 代謝 |
Outline of Final Research Achievements |
We previously argued that type 2 diabetic drug, metformin has an anti tumor effect mediated by the modulation of CD8 T cell function. In this study, we investigated further mechanisms of the effect on several mouse tumor implantation model. These results revealed the activation of AMPK in antigen-specific CD8 T cell by metformin is quite important for tumor regression. Metformin-induced AMPK activation led to enhance an aerobic glycolysis of CD8 T cell through cell membrane translocation of amino acid transpoter, LAT1. These data indicated CD8 T cell metabolism has an critical role for anti-tumor effect of metformin.
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Report
(3 results)
Research Products
(19 results)
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[Journal Article] Attenuation of CD4+CD25+regulatory T cells in the tumor microenvironment by metformin, a type 2 diabetes drug2017
Author(s)
Kunisada Y, Eikawa S, Tomonobu N, Domae S, Uehara T, Hori S, Furusawa Y, Hase K, Sasaki A, Udono H.
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Journal Title
EBioMedicine
Volume: 25
Pages: 154-164
DOI
NAID
Related Report
Peer Reviewed / Open Access
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[Journal Article] Study about the Efficacy of Metformin to Immune Function in Cancer Patients2016
Author(s)
Watanabe M, Yamamoto H, Eikawa S, Shien K, Shien T, Soh J, Hotta K, Wada J, Hinotsu S, Fujiwara T, Kiura K, Doihara H, Miyoshi S, Udono H, Toyooka S
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Journal Title
Acta Med Okayama
Volume: 70
Pages: 327-330
NAID
Related Report
Peer Reviewed / Int'l Joint Research
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[Presentation] Metformin enhances aerobic glycolysis and amino acids metabolism in CD8+ T cells2016
Author(s)
Shingo Eikawa, Nahoko Tomonobu, Fang He, Nahoko Yamashita, Mototsugu Watanabe, Yuji Kimura, Ichiro Nojima, Yuki Kunisada, Takenori Uehara, Chihiro Yamazaki, Shinji Fukuda, Koji Hase, Heiichiro Udono
Organizer
The 45th Annual Meeting of The Japanese Society for Immunology
Place of Presentation
沖縄コンベンションセンター
Year and Date
2016-12-07
Related Report
Int'l Joint Research
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[Presentation] Metformin enhances aerobic glycolysis and amino acids metabolism in CD8+ T cells2016
Author(s)
Shingo Eikawa, Nahoko Tomonobu, Fang He, Nahoko Yamashita, Mototsugu Watanabe, Yuji Kimura, Ichiro Nojima, Yuki Kunisada, Takenori Uehara, Chihiro Yamazaki, Shinji Fukuda, Koji Hase, Heiichiro Udono
Organizer
The 75th Annual Meeting of Japanese Cancer Association
Place of Presentation
パシフィコ横浜
Year and Date
2016-10-08
Related Report
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[Presentation] Metformin enhances aerobic glycolysis and amino acids metabolism in CD8+ T cells2016
Author(s)
Shingo Eikawa, Nahoko Tomonobu, Fang He, Nahoko Yamashita, Mototsugu Watanabe, Yuji Kimura, Ichiro Nojima, Yuki Kunisada, Takenori Uehara, Chihiro Yamazaki, Shinji Fukuda, Koji Hase, Heiichiro Udono
Organizer
第20回がん免疫学会総会
Place of Presentation
大阪国際交流センタ
Year and Date
2016-07-27
Related Report
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[Book] がん免疫療法2017
Author(s)
友信奈保子, 榮川伸吾, 鵜殿平一郎
Total Pages
173
Publisher
日本臨床
Related Report
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